Search Results - "Carlson, Scott"

Nonhistone Lysine Methylation in the Regulation of Cancer Pathways by Carlson, Scott M, Gozani, Or

“…Proteins are regulated by an incredible array of posttranslational modifications (PTMs). Methylation of lysine residues on histone proteins is a PTM with…”
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Emerging Technologies to Map the Protein Methylome by Carlson, Scott M., Gozani, Or

“…Protein methylation plays an integral role in cellular signaling, most notably by modulating proteins bound at chromatin and increasingly through regulation of…”
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A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation by Moore, Kaitlyn E., Carlson, Scott M., Camp, Nathan D., Cheung, Peggie, James, Richard G., Chua, Katrin F., Wolf-Yadlin, Alejandro, Gozani, Or

“…Lysine methylation of histone proteins regulates chromatin dynamics and plays important roles in diverse physiological and pathological processes. However,…”
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Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer by Reynoird, Nicolas, Mazur, Pawel K, Stellfeld, Timo, Flores, Natasha M, Lofgren, Shane M, Carlson, Scott M, Brambilla, Elisabeth, Hainaut, Pierre, Kaznowska, Ewa B, Arrowsmith, Cheryl H, Khatri, Purvesh, Stresemann, Carlo, Gozani, Or, Sage, Julien

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic options. We found that levels of the lysine methyltransferase SMYD2…”
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The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability by Paredes, Silvana, Angulo-Ibanez, Maria, Tasselli, Luisa, Carlson, Scott M., Zheng, Wei, Li, Tie-Mei, Chua, Katrin F.

“…In the yeast Saccharomyces cerevisiae, genomic instability in rDNA repeat sequences is an underlying cause of cell aging and is suppressed by the…”
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RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation by Carlson, Scott M., Soulette, Cameron M., Yang, Ze, Elias, Joshua E., Brooks, Angela N., Gozani, Or

“…In eukaryotes, precursor mRNA (pre-mRNA) splicing removes non-coding intron sequences to produce mature mRNA. This removal is controlled in part by RNA-binding…”
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Proteome-wide enrichment of proteins modified by lysine methylation by Carlson, Scott M, Moore, Kaitlyn E, Green, Erin M, Martín, Glòria Mas, Gozani, Or

“…We present a protocol for using the triple malignant brain tumor domains of L3MBTL1 (3xMBT), which bind to mono- and di-methylated lysine with minimal sequence…”
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A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme by Carlson, Scott M., Moore, Kaitlyn E., Sankaran, Saumya M., Reynoird, Nicolas, Elias, Joshua E., Gozani, Or

“…The lysine methyltransferase (KMT) SETMAR is implicated in the response to and repair of DNA damage, but its molecular function is not clear. SETMAR has been…”
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Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3 by Carlson, Scott M, Chouinard, Candace R, Labadorf, Adam, Lam, Carol J, Schmelzle, Katrin, Fraenkel, Ernest, White, Forest M

“…The mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase 2 (ERK2) is ubiquitously expressed in mammalian tissues and is involved in a…”
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Apolipoprotein E Genotype e2: Neuroprotection and Its Limits by Kim, Hyun, Devanand, Davangere P., Carlson, Scott, Goldberg, Terry E.

“…In this review, we comprehensively, qualitatively, and critically synthesized several features of APOE-e2, a known APOE protective variant, including its…”
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Increased patterns of risky behaviours among helmet wearers in skiing and snowboarding by Thomson, Cynthia J., Carlson, Scott R.

“…•Helmet use is associated with patterns of risk taking behaviours in snow sports.•Factors including male sex, proficiency, and sensation seeking predict risk…”
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Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis by Morel, Caroline, Carlson, Scott M., White, Forest M., Davis, Roger J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Externalizing behavior, the UPPS-P Impulsive Behavior scale and Reward and Punishment Sensitivity by Carlson, Scott R., Pritchard, Ashley A., Dominelli, Rachelle M.

“…► The UPPS-P is related to Externalizing behavior. ► It may not account for all variance related to Reward and Punishment Sensitivity. ► Reward Sensitivity was…”
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Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review by Lewinski, Allison A, Walsh, Conor, Rushton, Sharron, Soliman, Diana, Carlson, Scott M, Luedke, Matthew W, Halpern, David J, Crowley, Matthew J, Shaw, Ryan J, Sharpe, Jason A, Alexopoulos, Anastasia-Stefania, Tabriz, Amir Alishahi, Dietch, Jessica R, Uthappa, Diya M, Hwang, Soohyun, Ball Ricks, Katharine A, Cantrell, Sarah, Kosinski, Andrzej S, Ear, Belinda, Gordon, Adelaide M, Gierisch, Jennifer M, Williams, Jr, John W, Goldstein, Karen M

“…Extensive literature support telehealth as a supplement or adjunct to in-person care for the management of chronic conditions such as congestive heart failure…”
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Disinhibited characteristics and binge drinking among university student drinkers by Carlson, Scott R, Johnson, Season C, Jacobs, Pauline C

“…Abstract Binge drinking is a major problem at North American universities. Disinhibited traits have provided insight on other patterns of alcohol involvement,…”
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Modeling cell-specific dynamics and regulation of the common gamma chain cytokines by Farhat, Ali M., Weiner, Adam C., Posner, Cori, Kim, Zoe S., Orcutt-Jahns, Brian, Carlson, Scott M., Meyer, Aaron S.

“…The γ-chain receptor dimerizes with complexes of the cytokines interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21 and their corresponding “private”…”
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Trait impulsivity and prospective memory abilities: An exploratory study by Chang, Julie, Carlson, Scott R.

“…•Prospective memory and impulsivity may both reflect executive control.•Self reported prospective memory problems and impulsivity were related.•Behavioral…”
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Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML by Winter, Georg E, Rix, Uwe, Carlson, Scott M, Gleixner, Karoline V, Grebien, Florian, Gridling, Manuela, Müller, André C, Breitwieser, Florian P, Bilban, Martin, Colinge, Jacques, Valent, Peter, Bennett, Keiryn L, White, Forest M, Superti-Furga, Giulio

“…A systems-pharmacology approach reveals that the combined off-target activity of two kinase inhibitors that impedes MAPK signaling to decrease expression of…”
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Personality and risky downhill sports: Associations with impulsivity dimensions by Thomson, Cynthia J., Carlson, Scott R.

“…•We compared impulsivity traits among people differing in downhill sport proficiency.•Participation in downhill sports is associated with high Reward…”
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Hippocampal volume in patients with asthma: Results from the Dallas Heart Study by Carlson, Scott M., Kim, Julie, Khan, David A., King, Kevin, Lucarelli, Richard T., McColl, Roderick, Peshock, Ronald, Brown, E. Sherwood

“…Introduction: Asthma is associated with an increased risk of mild cognitive impairment and dementia. Depression and oral corticosteroid use are associated with…”
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