Search Results - "Carlson, Gregory"
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High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice
Published in Neurobiology of disease (01-07-2014)“…Abstract Insulin resistance and other features of the metabolic syndrome are increasingly recognized for their effects on cognitive health. To ascertain…”
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Neuropathic pain and SCI: Identification and treatment strategies in the 21st century
Published in Journal of the neurological sciences (15-01-2018)“…Pain is a common complication in patients following spinal cord injury (SCI), with studies citing up to 80% of patients reporting some form of pain…”
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Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses
Published in Nature neuroscience (01-02-2012)“…Rett syndrome (RTT) is caused by mutations in MeCP2. This study describes a new line of knock-in mutant mice that mimics a MeCP2 mutation found in individuals…”
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Dynamic Regulation of Synaptic GABA Release by the Glutamate-Glutamine Cycle in Hippocampal Area CA1
Published in The Journal of neuroscience (16-08-2006)“…Vesicular GABA and intraterminal glutamate concentrations are in equilibrium, suggesting inhibitory efficacy may depend on glutamate availability. Two main…”
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Disrupted Dentate Granule Cell Chloride Regulation Enhances Synaptic Excitability during Development of Temporal Lobe Epilepsy
Published in The Journal of neuroscience (19-12-2007)“…GABA(A) receptor-mediated inhibition depends on the maintenance of intracellular Cl- concentration ([Cl-]in) at low levels. In neurons in the developing CNS,…”
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Pyramidal Cell Selective Ablation of N -Methyl-D-Aspartate Receptor 1 Causes Increase in Cellular and Network Excitability
Published in Biological psychiatry (1969) (15-03-2015)“…Abstract Background Neuronal activity at gamma frequency is impaired in schizophrenia (SZ) and is considered critical for cognitive performance. Such…”
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Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10 , an Autism Associated Gene
Published in Biological psychiatry (1969) (01-02-2017)“…Abstract Background Behavioral symptoms in individuals with autism spectrum disorder (ASD) have been attributed to abnormal neuronal connectivity, but the…”
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Functional regulation of the dentate gyrus by GABA-mediated inhibition
Published in Progress in brain research (2007)“…Dentate granule cells are characterized by their low levels of excitability, an important aspect of hippocampal function, which distinguishes them from other…”
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Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
Published in Proceedings of the National Academy of Sciences - PNAS (25-10-2011)“…DTNBP1 (dystrobrevin binding protein 1) is a leading candidate susceptibility gene in schizophrenia and is associated with working memory capacity in normal…”
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Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits
Published in Neuropsychopharmacology (New York, N.Y.) (01-06-2014)“…NMDA-receptor (NMDAR) hypofunction is strongly implicated in the pathophysiology of schizophrenia. Several convergent lines of evidence suggest that net…”
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Massive and Specific Dysregulation of Direct Cortical Input to the Hippocampus in Temporal Lobe Epilepsy
Published in The Journal of neuroscience (15-11-2006)“…Epilepsy affects 1-2% of the population, with temporal lobe epilepsy (TLE) the most common variant in adults. Clinical and experimental studies have…”
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Tibial Tubercle Preserving Anterior Closing Wedge Proximal Tibial Osteotomy and ACL Tunnel Bone Grafting for Increased Posterior Tibial Slope in Failed ACL Reconstructions
Published in Arthroscopy techniques (Amsterdam) (01-10-2021)“…Anterior cruciate ligament reconstruction (ACLR) failure is multifactorial, but it is known that increased posterior tibial slope (PTS) leads to a greater…”
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Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function
Published in Hippocampus (01-02-2012)“…Genetic studies have associated deficient function of the serine/threonine kinase Akt1 with schizophrenia. This disorder is associated with developmental,…”
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Proximal Tibial Opening Wedge Osteotomy for the Treatment of Posterior Knee Instability and Genu Recurvatum Secondary to Increased Anterior Tibial Slope
Published in Arthroscopy techniques (Amsterdam) (01-12-2021)“…Decreased posterior tibial slope has been associated with increased risk of graft failure and knee instability after posterior cruciate ligament (PCL)…”
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MeCP2-mediated alterations of striatal features accompany psychomotor deficits in a mouse model of Rett syndrome
Published in Brain Structure and Function (01-01-2015)“…Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 ( MECP2 ) gene. Affected individuals develop motor…”
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Protocadherin 10 alters γ oscillations, amino acid levels, and their coupling; baclofen partially restores these oscillatory deficits
Published in Neurobiology of disease (01-12-2017)“…Approximately one in 45 children have been diagnosed with Autism Spectrum Disorder (ASD), which is characterized by social/communication impairments. Recent…”
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Revision Proximal Tibiofibular Joint Reconstruction for the Treatment of Chronic Instability Secondary to Suture Button Construct Failure
Published in Arthroscopy techniques (Amsterdam) (01-03-2022)“…Recurrent proximal tibiofibular joint (PTFJ) instability can result from nonanatomic repair using a suture button construct. During initial reconstruction,…”
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Temporally dependent changes in cocaine-induced synaptic plasticity in the nucleus accumbens shell are reversed by D1-like dopamine receptor stimulation
Published in Neuropsychopharmacology (New York, N.Y.) (01-06-2012)“…Dopaminergic and glutamatergic inputs to the nucleus accumbens shell have a central role in reward processing. Non-contingent cocaine administration generates…”
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