Search Results - "Carlson, C. George"

The effect of specific IKKβ inhibitors on the cytosolic expression of IκB-α and the nuclear expression of p65 in dystrophic (MDX) muscle by Carlson, C George, Dole, Elizabeth, Stefanski, Casey, Bayless, David

“…The efficacy of two highly specific IκB-α kinase β (IKK-β) inhibitors in reducing the enhanced basal activation of the NF-κB pathway in dystrophic muscle was…”
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Characterizing vertical forest structure using small-footprint airborne LiDAR by Zimble, Daniel A., Evans, David L., Carlson, George C., Parker, Robert C., Grado, Stephen C., Gerard, Patrick D.

“…Characterization of forest attributes at fine scales is necessary to manage terrestrial resources in a manner that replicates, as closely as possible, natural…”
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Soluble activin receptor type IIB increases forward pulling tension in the mdx mouse by George Carlson, C., Bruemmer, Kay, Sesti, Jenna, Stefanski, Casey, Curtis, Heather, Ucran, Jeffrey, Lachey, Jennifer, Seehra, Jasbir S.

“…Introduction: In this study we investigated the action of RAP‐031, a soluble activin receptor type IIB (ActRIIB) comprised of a form of the ActRIIB…”
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A simple protocol for assessing inter-trial and inter-examiner reliability for two noninvasive measures of limb muscle strength by Carlson, C. George, Rutter, John, Bledsoe, Cathy, Singh, Rajvir, Hoff, Helena, Bruemmer, Kay, Sesti, Jenna, Gatti, Francesca, Berge, Jonas, McCarthy, Laura

“…Noninvasive measures of limb muscle strength are quite useful in preclinical translational studies that use mouse models of muscle disease, peripheral nerve…”
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Postnatal Hyperplasic Effects of ActRIIB Blockade in a Severely Dystrophic Muscle by Nielsen, Cory, Potter, Ross M., Borowy, Christopher, Jacinto, Kimberly, Kumar, Ravi, Carlson, C. George

“…The efficacy of two ActRIIB ligand‐trapping agents (RAP‐031 and RAP‐435) in treating muscular dystrophy was examined by determining their morphological effects…”
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In vivo treatment with the NF-κB inhibitor ursodeoxycholic acid (UDCA) improves tension development in the isolated mdx costal diaphragm by Carlson, C. George, Potter, Ross, Yu, Vivien, Luo, Kevin, Lavin, Jesse, Nielsen, Cory

“…ABSTRACT Introduction: Previous experiments have indicated that in vivo administration of ursodeoxycholic acid (UDCA) inhibits nuclear NF‐κB activation and has…”
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Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors by Takahashi, Masazumi, Kubo, Tai, Mizoguchi, Akira, Carlson, C George, Endo, Katsuaki, Ohnishi, Katsunori

“…In mammals, two combinations of muscle nicotinic acetylcholine receptors (AChRs) are used: α2βγδ (γ‐AChR) or α2βϵδ (ϵ‐AChR). After birth, γ‐AChRs are replaced…”
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Adult dystrophic (mdx) endplates exhibit reduced quantal size and enhanced quantal variation by Carlson, C G, Roshek, D M

“…Examination of miniature endplate potential (MEPP) distributions indicated that the average quantal size is significantly reduced by approximately 44% in young…”
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Agents Which Inhibit NF-κB Signaling Block Spontaneous Contractile Activity and Negatively Influence Survival of Developing Myotubes by Carlson, C. George, Stein, Lauren, Dole, Elizabeth, Potter, Ross M., Bayless, David

“…Inhibiting the NF‐κB signaling pathway provides morphological and functional benefits for the mdx mouse, a model for Duchenne muscular dystrophy characterized…”
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Rapid, non-genomic actions of progesterone and estradiol on steady-state calcium and resting calcium influx in lens epithelial cells by Samadi, Abbas, Carlson, C George, Gueorguiev, Anton, Cenedella, Richard J

“…The effects of steroids on the steady-state intracellular [Ca(2+)] ([Ca(2+)](i)) and resting Ca(2+) influx in Fura-2-loaded bovine lens epithelial cells were…”
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Chronic treatment with agents that stabilize cytosolic IκB-α enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch by Carlson, C. George, Samadi, Abbas, Siegel, Ashley

“…The potential pathogenic role of increased NFκB signaling in passively stretched dystrophic skeletal muscle was examined by treating adult mdx mice with an…”
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Resting Ca2+ influx does not contribute to anoxia-induced cell death in adult rat cardiac myocytes by Mont, Meghan R, Carlson, C George, Geisbuhler, Timothy P

“…Calcium has been proposed as a primary influence on cell death during ischemic episodes in myocardial cells. One component of calcium entry into a cell is…”
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Extrajunctional resting Ca influx is not increased in a severely dystrophic expiratory muscle (triangularis sterni) of the mdx mouse by Carlson, C George, Gueorguiev, Anton, Roshek, Diana M, Ashmore, Rebecca, Chu, Jacquelyne S, Anderson, Judy E

“…Freshly isolated adult mdx and nondystrophic (C57B110SnJ) muscle fibers were used to examine the potential role of resting Ca2+ influx in the pathogenesis of…”
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Diethylstilbestrol increases intracellular calcium in lens epithelial cells by Samadi, Abbas, Cenedella, Richard J, Carlson, C George

“…The effects of diethylstilbestrol (DES) on steady-state intracellular calcium concentration ([Ca(2+)](i)) and resting Ca(2+) influx were examined in primary…”
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Agents Which Inhibit NF-[kappa]B Signaling Block Spontaneous Contractile Activity and Negatively Influence Survival of Developing Myotubes by Carlson, C George, Stein, Lauren, Dole, Elizabeth, Potter, Ross M, Bayless, David

“…Inhibiting the NF-[kappa]B signaling pathway provides morphological and functional benefits for the mdx mouse, a model for Duchenne muscular dystrophy…”
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In vivo treatment with the NF-[kappa]B inhibitor ursodeoxycholic acid (UDCA) improves tension development in the isolated mdx costal diaphragm by Carlson, C George, Potter, Ross, Yu, Vivien, Luo, Kevin, Lavin, Jesse, Nielsen, Cory

“…Introduction: Previous experiments have indicated that in vivo administration of ursodeoxycholic acid (UDCA) inhibits nuclear NF-[kappa]B activation and has…”
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The effects of two TGF‐beta superfamily ligand trapping agents on the morphology of dystrophic (mdx) Triangularis Sterni (TS) muscle by Nielsen, Cory, Borowy, Christopher, Jacinto, Kimberly, Potter, Ross, Kaminski, Carter, Kumar, Ravi, Carlson, C George

“…Abstract only The severely dystrophic mdx TS muscle provides a useful template for examining the translational efficacy of various signaling modulators in…”
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The effect of an ActRIIB ligand trapping agent on the number of satellite cells and myonuclei in dystrophic (mdx) muscle fibers by Jacinto, Kimberly, Borowy, Christopher, Nielsen, Cory, Potter, Ross, Kumar, Ravi, Carlson, C George

“…Abstract only Duchenne muscular dystrophy is characterized by repeated cycles of degeneration and regeneration ultimately leading to respiratory failure and…”
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Short‐ and long‐term effects of ActRIIB receptor ligand trapping agents on muscle mass and downstream signaling in dystrophic (mdx) limb and respiratory musculature (1102.44) by Potter, Ross, Desai, Pooja, Nielsen, Cory, Corbell, Kathryn, Mellon, Christopher, Danishyar, Amina, Gatti, Francesca, Grinberg, Asya, Kumar, Ravi, Carroll, Chad, Carlson, C. George

“…These studies examined the translational efficacy and the signaling consequences of in vivo treatment with two soluble ActRIIB receptor ligand trapping agents…”
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Treatment with inhibitors of the NF-κB pathway improves whole body tension development in the mdx mouse by Siegel, Ashley L, Bledsoe, Cathy, Lavin, Jesse, Gatti, Francesca, Berge, Jonas, Millman, Gregory, Turin, Eric, Winders, W. Tyler, Rutter, John, Palmeiri, Beniamino, Carlson, C. George

“…Abstract The whole body tension (WBT) method was used to evaluate the hypothesis that long term treatment with NF-κB inhibitors improves the total forward…”
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