Search Results - "Carlos Frederico Martins Menck"

Whole-exome sequencing reveals the impact of UVA light mutagenesis in xeroderma pigmentosum variant human cells by Moreno, Natália Cestari, de Souza, Tiago Antonio, Garcia, Camila Carrião Machado, Ruiz, Nathalia Quintero, Corradi, Camila, Castro, Ligia Pereira, Munford, Veridiana, Ienne, Susan, Alexandrov, Ludmil B, Menck, Carlos Frederico Martins

“…UVA-induced mutagenesis was investigated in human pol eta-deficient (XP-V) cells through whole-exome sequencing. In UVA-irradiated cells, the increase in the…”
Get full text

Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries by Rocha, Clarissa Ribeiro Reily, Reily Rocha, Alexandre, Molina Silva, Matheus, Rodrigues Gomes, Luciana, Teatin Latancia, Marcela, Andrade Tomaz, Marina, de Souza, Izadora, Karolynne Seregni Monteiro, Linda, Menck, Carlos Frederico Martins

“…Glioblastoma is a severe type of brain tumor with a poor prognosis and few therapy options. Temozolomide (TMZ) is one of these options, however, with limited…”
Get full text

DNA repair pathways and cisplatin resistance: an intimate relationship by Rocha, Clarissa Ribeiro Reily, Silva, Matheus Molina, Quinet, Annabel, Cabral-Neto, Januario Bispo, Menck, Carlos Frederico Martins

“…The main goal of chemotherapeutic drugs is to induce massive cell death in tumors. Cisplatin is an antitumor drug widely used to treat several types of cancer…”
Get full text

Melanopsin (Opn4) is an oncogene in cutaneous melanoma by de Assis, Leonardo Vinícius Monteiro, Lacerda, José Thalles, Moraes, Maria Nathália, Domínguez-Amorocho, Omar Alberto, Kinker, Gabriela Sarti, Mendes, Davi, Silva, Matheus Molina, Menck, Carlos Frederico Martins, Câmara, Niels Olsen Saraiva, Castrucci, Ana Maria de Lauro

“…The search for new therapeutical targets for cutaneous melanoma and other cancers is an ongoing task. We expanded this knowledge by evaluating whether opsins,…”
Get full text

The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells by Silva, Matheus Molina, Rocha, Clarissa Ribeiro Reily, Kinker, Gabriela Sarti, Pelegrini, Alessandra Luiza, Menck, Carlos Frederico Martins

“…Lung cancer patients face a dismal prognosis mainly due to the low efficacy of current available treatments. Cisplatin is the first-line chemotherapy treatment…”
Get full text

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells by Quinet, Annabel, Martins, Davi Jardim, Vessoni, Alexandre Teixeira, Biard, Denis, Sarasin, Alain, Stary, Anne, Menck, Carlos Frederico Martins

“…Ultraviolet-induced 6-4 photoproducts (6-4PP) and cyclobutane pyrimidine dimers (CPD) can be tolerated by translesion DNA polymerases (TLS Pols) at stalled…”
Get full text

Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells by de Oliveira Alves, Nilmara, Vessoni, Alexandre Teixeira, Quinet, Annabel, Fortunato, Rodrigo Soares, Kajitani, Gustavo Satoru, Peixoto, Milena Simões, Hacon, Sandra de Souza, Artaxo, Paulo, Saldiva, Paulo, Menck, Carlos Frederico Martins, Batistuzzo de Medeiros, Silvia Regina

“…Most of the studies on air pollution focus on emissions from fossil fuel burning in urban centers. However, approximately half of the world's population is…”
Get full text

Inflammation response, oxidative stress and DNA damage caused by urban air pollution exposure increase in the lack of DNA repair XPC protein by de Oliveira Alves, Nilmara, Martins Pereira, Guilherme, Di Domenico, Marlise, Costanzo, Giovanna, Benevenuto, Sarah, de Oliveira Fonoff, Adriana M., de Souza Xavier Costa, Natália, Ribeiro Júnior, Gabriel, Satoru Kajitani, Gustavo, Cestari Moreno, Natália, Fotoran, Wesley, Iannicelli Torres, Janaína, de Andrade, Jailson Bittencourt, Matera Veras, Mariana, Artaxo, Paulo, Menck, Carlos Frederico Martins, de Castro Vasconcellos, Pérola, Saldiva, Paulo

“…•PM2.5 inflammatory response has been studied on mice with or without XPC protein.•XPC-knockout mice show an increased oxidative stress response to PM2.5…”
Get full text

NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells by Rocha, Clarissa Ribeiro Reily, Kajitani, Gustavo Satoru, Quinet, Annabel, Fortunato, Rodrigo Soares, Menck, Carlos Frederico Martins

“…Cancer is a leading cause of death worldwide, and while great advances have been made particularly in chemotherapy, many types of cancer still present a dismal…”
Get full text

NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide by Melo‐Hanchuk, Talita Diniz, Slepicka, Priscila Ferreira, Pelegrini, Alessandra Luiza, Menck, Carlos Frederico Martins, Kobarg, Jörg

“…Cells are daily submitted to high levels of DNA lesions that trigger complex pathways and cellular responses by cell cycle arrest, apoptosis, alterations in…”
Get full text

ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation by Gomes, Luciana Rodrigues, Rocha, Clarissa Ribeiro Reily, Martins, Davi Jardim, Fiore, Ana Paula Zen Petisco, Kinker, Gabriela Sarti, Bruni-Cardoso, Alexandre, Menck, Carlos Frederico Martins

“…Tissue architecture and cell–extracellular matrix (cell–ECM) interaction determine the organ specificity; however, the influences of these factors on…”
Get full text

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells by Quinet, Annabel, Martins, Davi Jardim, Vessoni, Alexandre Teixeira, Biard, Denis, Sarasin, Alain, Stary, Anne, Menck, Carlos Frederico Martins

“…Ultraviolet-induced 6-4 photoproducts (6-4PP) and cyclobutane pyrimidine dimers (CPD) can be tolerated by translesion DNA polymerases (TLS Pols) at stalled…”
Get full text

DNA Damage Induced by Late Spring Sunlight in Antarctica by Fuentes‐León, Fabiana, Peres de Oliveira, Andressa, Quintero‐Ruiz, Nathalia, Munford, Veridiana, Satoru Kajitani, Gustavo, Coimbra Brum, Antônio, Schuch, André Passaglia, Colepicolo, Pio, Sánchez‐Lamar, Angel, Menck, Carlos Frederico Martins

“…Sunlight ultraviolet (UV) radiation constitutes an important environmental genotoxic agent that organisms are exposed to, as it can damage DNA directly,…”
Get full text

Horizontal Gene Transfer Building Prokaryote Genomes: Genes Related to Exchange Between Cell and Environment are Frequently Transferred by Paquola, Apuã C. M., Asif, Huma, Pereira, Carlos Alberto de Bragança, Feltes, Bruno César, Bonatto, Diego, Lima, Wanessa Cristina, Menck, Carlos Frederico Martins

“…Horizontal gene transfer (HGT) has a major impact on the evolution of prokaryotic genomes, as it allows genes evolved in different contexts to be combined in a…”
Get full text

The role of DNA repair in the pluripotency and differentiation of human stem cells by Rocha, Clarissa Ribeiro Reily, Lerner, Leticia Koch, Okamoto, Oswaldo Keith, Marchetto, Maria Carolina, Menck, Carlos Frederico Martins

“…All living cells utilize intricate DNA repair mechanisms to address numerous types of DNA lesions and to preserve genomic integrity, and pluripotent stem cells…”
Get full text

Direct participation of DNA in the formation of singlet oxygen and base damage under UVA irradiation by Yagura, Teiti, Schuch, André Passaglia, Garcia, Camila Carrião Machado, Rocha, Clarissa Ribeiro Reily, Moreno, Natália Cestari, Angeli, José Pedro Friedmann, Mendes, Davi, Severino, Divinomar, Bianchini Sanchez, Angelica, Di Mascio, Paolo, de Medeiros, Marisa Helena Gennari, Menck, Carlos Frederico Martins

“…UVA light is hardly absorbed by the DNA molecule, but recent works point to a direct mechanism of DNA lesion by these wavelengths. UVA light also excite…”
Get full text

ATR/Chk1 Pathway is Activated by Oxidative Stress in Response to UVA Light in Human Xeroderma Pigmentosum Variant Cells by Moreno, Natália Cestari, Garcia, Camila Carrião Machado, Rocha, Clarissa Ribeiro Reily, Munford, Veridiana, Menck, Carlos Frederico Martins

“…The crucial role of DNA polymerase eta in protecting against sunlight‐induced tumors is evidenced in Xeroderma Pigmentosum Variant (XP‐V) patients, who carry…”
Get full text

Editorial: DNA repair and immune response by Basso, Paulo José, Rocha, Clarissa Ribeiro Reily, Biessen, Erik A. L., Pluijm, Ingrid Van der, Menck, Carlos Frederico Martins, Câmara, Niels Olsen Saraiva

Get full text

Genoprotective Effect of Phyllanthus orbicularis Extract Against UVA, UVB, and Solar Radiation by Tamayo, Marioly Vernhes, Schuch, André Passaglia, Yagura, Teiti, Gil, Luis Baly, Menck, Carlos Frederico Martins, Sánchez‐Lamar, Angel

“…One approach to protect the human skin against harmful effects of solar ultraviolet (UV) radiation was to use natural products as photoprotectors. In this…”
Get full text

Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB/CS allele or the noncancer-prone XPB/TTD allele by AUGUSTO DA COSTA, Renata Maria, RIOU, Lydia, PAQUOLA, Apua, MARTINS MENCK, Carlos Frederico, SARASIN, Alain

“…Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) syndromes are characterized by deficiency in nucleotide excision repair pathway, but with…”
Get full text