Search Results - "Carlisle, Holly J."

Assessment of motor balance and coordination in mice using the balance beam by Luong, Tinh N, Carlisle, Holly J, Southwell, Amber, Patterson, Paul H

“…Brain injury, genetic manipulations, and pharmacological treatments can result in alterations of motor skills in mice. Fine motor coordination and balance can…”
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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases by Walkup, Ward G., Washburn, Lorraine, Sweredoski, Michael J., Carlisle, Holly J., Graham, Robert L., Hess, Sonja, Kennedy, Mary B.

“…synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrations in the postsynaptic density (PSD) fraction from the…”
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Identification of modulators of autophagic flux in an image-based high content siRNA screen by Hale, Christopher M., Cheng, Qingwen, Ortuno, Danny, Huang, Ming, Nojima, Dana, Kassner, Paul D., Wang, Songli, Ollmann, Michael M., Carlisle, Holly J.

“…Autophagy is the primary process for recycling cellular constituents through lysosomal degradation. In addition to nonselective autophagic engulfment of…”
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SynGAP Regulates Steady-State and Activity-Dependent Phosphorylation of Cofilin by Carlisle, Holly J, Manzerra, Pasquale, Marcora, Edoardo, Kennedy, Mary B

“…SynGAP, a prominent Ras/Rap GTPase-activating protein in the postsynaptic density, regulates the timing of spine formation and trafficking of glutamate…”
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Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity by Carlisle, Holly J., Fink, Ann E., Grant, Seth G. N., O’Dell, Thomas J.

“…The membrane-associated guanylate kinases (MAGUKs) PSD-95, PSD-93 and SAP102 are thought to have crucial roles in both AMPA receptor trafficking and formation…”
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G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage by Pena, Nicholas, Richbourg, Tara, Gonzalez-Hunt, Claudia P., Qi, Rui, Wren, Paul, Barlow, Carrolee, Shanks, Natalie F., Carlisle, Holly J., Sanders, Laurie H.

“…Pathogenic mutations in LRRK2 cause Parkinson’s disease (PD). The G2019S variant is the most common, which results in abnormally high kinase activity…”
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Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases? [version 2; peer review: 3 approved] by Ortuno, Daniel, Carlisle, Holly J, Miller, Silke

“…A common pathological hallmark of age-related neurodegenerative diseases is the intracellular accumulation of protein aggregates such as α-synuclein in…”
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Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases? by Ortuno, Daniel, Carlisle, Holly J, Miller, Silke

“…A common pathological hallmark of age-related neurodegenerative diseases is the intracellular accumulation of protein aggregates such as α-synuclein in…”
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The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment by Arbuckle, Margaret I, Komiyama, Noboru H, Delaney, Ada, Coba, Marcelo, Garry, Emer M, Rosie, Roberta, Allchorne, Andrew J, Forsyth, Lynsey H, Bence, Matthew, Carlisle, Holly J, O'Dell, Thomas J, Mitchell, Rory, Fleetwood-Walker, Susan M, Grant, Seth G N

“…Sensitization to inflammatory pain is a pathological form of neuronal plasticity that is poorly understood and treated. Here we examine the role of the SH3…”
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Postsynaptic Induction and Presynaptic Expression of Group 1 mGluR-Dependent LTD in the Hippocampal CA1 Region by Watabe, Ayako M, Carlisle, Holly J, O'Dell, Thomas J

“…  1 Department of Physiology and   2 Interdepartmental Ph.D. Program for Neuroscience, UCLA School of Medicine, Los Angeles, California 90095 Watabe, Ayako M.,…”
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Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity by Garofalo, Albert W., Schwarz, Jacob, Zobel, Kerry, Beato, Claudia, Bernardi, Silvia, Budassi, Federica, Caberlotto, Laura, Gao, Peng, Griffante, Cristiana, Liu, Xinying, Migliore, Marco, Qiao, Feifei, Sabbatini, Fabio Maria, Sava, Anna, Zhang, Mingliang, Carlisle, Holly J.

“…[Display omitted] The G2019S variant of LRRK2, which causes an increase in kinase activity, is associated with the occurrence of Parkinson’s disease (PD)…”
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Selective Inhibitors of G2019S-LRRK2 Kinase Activity by Garofalo, Albert W, Bright, Jessica, De Lombaert, Stéphane, Toda, Alyssa M. A, Zobel, Kerry, Andreotti, Daniele, Beato, Claudia, Bernardi, Silvia, Budassi, Federica, Caberlotto, Laura, Gao, Peng, Griffante, Cristiana, Liu, Xinying, Mengatto, Luisa, Migliore, Marco, Sabbatini, Fabio Maria, Sava, Anna, Serra, Elena, Vincetti, Paolo, Zhang, Mingliang, Carlisle, Holly J

“…Pathogenic variants in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified that increase the risk for developing Parkinson’s disease in a…”
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Differential Inhibition of LRRK2 in Parkinson's Disease Patient Blood by a G2019S Selective LRRK2 Inhibitor by Bright, Jessica M., Carlisle, Holly J., Toda, Alyssa M. A., Murphy, Molly, Molitor, Tyler P., Wren, Paul, Andruska, Kristin M., Liu, Enchi, Barlow, Carrolee

“…ABSTRACT Background A common genetic mutation that causes Parkinson's disease (PD) is the G2019S LRRK2 mutation. A precision medicine approach that selectively…”
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Spine architecture and synaptic plasticity by Carlisle, Holly J., Kennedy, Mary B.

“…Many forms of mental retardation and cognitive disability are associated with abnormalities in dendritic spine morphology. Visualization of spines using…”
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Integration of biochemical signalling in spines by Kennedy, Mary B, Beale, Holly C, Carlisle, Holly J, Washburn, Lorraine R

“…Short-term and long-term changes in the strength of synapses in neural networks underlie working memory and long-term memory storage in the brain. These…”
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Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction by Carlisle, Holly J, Luong, Tinh N, Medina-Marino, Andrew, Schenker, Leslie, Khorosheva, Eugenia, Indersmitten, Tim, Gunapala, Keith M, Steele, Andrew D, O'Dell, Thomas J, Patterson, Paul H, Kennedy, Mary B

“…Densin is an abundant scaffold protein in the postsynaptic density (PSD) that forms a high-affinity complex with αCaMKII and α-actinin. To assess the function…”
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SynGAP Regulates ERK/MAPK Signaling, Synaptic Plasticity, and Learning in the Complex with Postsynaptic Density 95 and NMDA Receptor by Komiyama, Noboru H, Watabe, Ayako M, Carlisle, Holly J, Porter, Karen, Charlesworth, Paul, Monti, Jennifer, Strathdee, Douglas J. C, O'Carroll, Colin M, Martin, Stephen J, Morris, Richard G. M, O'Dell, Thomas J, Grant, Seth G. N

“…At excitatory synapses, the postsynaptic scaffolding protein postsynaptic density 95 (PSD-95) couples NMDA receptors (NMDARs) to the Ras GTPase-activating…”
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Assessment of Motor Balance and Coordination in Mice using the Balance Beam by Luong, Tinh N., Carlisle, Holly J., Southwell, Amber, Patterson, Paul H.

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The influence of an endogenous β3 subunit on recombinant GABA A receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells by Davies, Paul A, Hoffmann, Ewa B, Carlisle, Holly J, Tyndale, Rachel F, Hales, Tim G

“…Cell lines are commonly used for studying recombinant heterooligomeric ion channels with defined subunit composition. Such studies often ignore the…”
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A nitric oxide-independent and beta-adrenergic receptor-sensitive form of metaplasticity limits theta-frequency stimulation-induced LTP in the hippocampal CA1 region by Moody, T D, Carlisle, H J, O'Dell, T J

“…The induction of long-term potentiation (LTP) and long-term depression (LTD) at excitatory synapses in the hippocampus can be strongly modulated by patterns of…”
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