A Natural Deletion of the HoxC Cluster in Elasmobranch Fishes

A Natural Deletion of the HoxC Cluster in Elasmobranch Fishes

Hox proteins are a metazoan-specific family of transcription factors that are required for developmental patterning. The genomic arrangement of Hox genes into four paralogous clusters is a primitive feature of jawed vertebrates. By using high-throughput sequencing, we demonstrate the absence of all...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) Vol. 334; no. 6062; p. 1517
Main Authors: King, Benjamin L., Gillis, J. Andrew, Carlisle, Heather R., Dahn, Randall D.
Format: Journal Article
Language:English
Published: Washington, DC American Association for the Advancement of Science 16-12-2011
The American Association for the Advancement of Science
Subjects:
Animals
Biological and medical sciences
BREVIA
Classical genetics, quantitative genetics, hybrids
Elasmobranchii
Fish
Fundamental and applied biological sciences. Psychology
Gene Deletion
Gene Silencing
Genes
Genetics of eukaryotes. Biological and molecular evolution
Genomes
Genomics
Homeodomain Proteins - genetics
Leucoraja erinacea
Marine
MicroRNA
MicroRNAs - genetics
Multigene Family
Pisces
Proteins
Scyliorhinus canicula
Sharks
Sharks - genetics
Skates (Fish) - genetics
Vertebrata
Vertebrates
Deletion
Vertebrata
Mutation
Genome
Pisces
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Summary:Hox proteins are a metazoan-specific family of transcription factors that are required for developmental patterning. The genomic arrangement of Hox genes into four paralogous clusters is a primitive feature of jawed vertebrates. By using high-throughput sequencing, we demonstrate the absence of all HoxC transcripts from embryos of the shark Scyliorhinus canicula and the skate Leucoraja erinacea and the absence of all HoxC genes and two HoxC-associated microRNAs from the genome of L. erinacea. These data suggest a loss of the entire HoxC cluster in elasmobranch fishes and represent evidence for the natural deletion of an entire Hox cluster in vertebrates.
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Present Address: 3018 Prairie Road, Madison, WI, 53719
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1210912