Search Results - "Carling, Gillian K"

Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience by Udeochu, Joe C., Amin, Sadaf, Huang, Yige, Fan, Li, Torres, Eileen Ruth S., Carling, Gillian K., Liu, Bangyan, McGurran, Hugo, Coronas-Samano, Guillermo, Kauwe, Grant, Mousa, Gergey Alzaem, Wong, Man Ying, Ye, Pearly, Nagiri, Ravi Kumar, Lo, Iris, Holtzman, Julia, Corona, Carlo, Yarahmady, Allan, Gill, Michael T., Raju, Ravikiran M., Mok, Sue-Ann, Gong, Shiaoching, Luo, Wenjie, Zhao, Mingrui, Tracy, Tara E., Ratan, Rajiv R., Tsai, Li-Huei, Sinha, Subhash C., Gan, Li

“…Pathological hallmarks of Alzheimer’s disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of…”
Get full text

AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation by Sayed, Faten A, Kodama, Lay, Fan, Li, Carling, Gillian K, Udeochu, Joe C, Le, David, Li, Qingyun, Zhou, Lu, Wong, Man Ying, Horowitz, Rose, Ye, Pearly, Mathys, Hansruedi, Wang, Minghui, Niu, Xiang, Mazutis, Linas, Jiang, Xueqiao, Wang, Xueting, Gao, Fuying, Brendel, Matthew, Telpoukhovskaia, Maria, Tracy, Tara E, Frost, Georgia, Zhou, Yungui, Li, Yaqiao, Qiu, Yue, Cheng, Zuolin, Yu, Guoqiang, Hardy, John, Coppola, Giovanni, Wang, Fei, DeTure, Michael A, Zhang, Bin, Xie, Lei, Trajnowski, John Q, Lee, Virginia M Y, Gong, Shiaoching, Sinha, Subhash C, Dickson, Dennis W, Luo, Wenjie, Gan, Li

“…The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 ( ), a microglia-specific gene in the brain, increases risk for late-onset…”
Get more information

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation by Parra Bravo, Celeste, Giani, Alice Maria, Madero-Perez, Jesus, Zhao, Zeping, Wan, Yuansong, Samelson, Avi J, Wong, Man Ying, Evangelisti, Alessandro, Cordes, Ethan, Fan, Li, Ye, Pearly, Zhu, Daphne, Pozner, Tatyana, Mercedes, Maria, Patel, Tark, Yarahmady, Allan, Carling, Gillian K, Sterky, Fredrik H, Lee, Virginia M Y, Lee, Edward B, DeTure, Michael, Dickson, Dennis W, Sharma, Manu, Mok, Sue-Ann, Luo, Wenjie, Zhao, Mingrui, Kampmann, Martin, Gong, Shiaoching, Gan, Li

“…Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models…”
Get more information

Alzheimer's Disease-Linked Risk Alleles Elevate Microglial cGAS-Associated Senescence and Neurodegeneration in a Tauopathy Model by Carling, Gillian K

“…The strongest risk factors for late-onset sporadic Alzheimer’s disease (AD) include the E4 allele of apolipoprotein E (APOE), the R47H variant of triggering…”
Get full text