Search Results - "Carlin, Nils"

Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in mice by Tobias, Joshua, Svennerholm, Ann-Mari, Carlin, Nils I.A, Lebens, Michael, Holmgren, Jan

“…Abstract Coli surface antigen 6 (CS6) is one of the most prevalent non-fimbrial colonization factors (CFs) of enterotoxigenic Escherichia coli (ETEC) bacteria,…”
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A Novel Glucosyltransferase Involved in O-Antigen Modification of Shigella flexneri Serotype 1c by STAGG, Robert M, TANG, Swee-Seong, CARLIN, Nils I. A, TALUKDER, Kaisar A, CAM, Phung D, VERMA, Naresh K

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Preparation and preclinical evaluation of a freeze-dried formulation of a novel combined multivalent whole-cell/B-subunit oral vaccine against enterotoxigenic Escherichia coli diarrhea by Borde, Annika, Ekman, Annelie, Larsson, Anette, Carlin, Nils, Holmgren, Jan, Tobias, Joshua

“…[Display omitted] A promising liquid killed multivalent whole-cell plus enterotoxin B-subunit oral vaccine against enterotoxigenic Escherichia coli (ETEC), the…”
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Shigella flexneri serotype 1c derived from serotype 1a by acquisition of gtrIC gene cluster via a bacteriophage by Tang, Swee-Seong, Carlin, Nils I A, Talukder, Kaisar A, Cam, Phung D, Verma, Naresh K

“…Shigella spp. are the primary causative agents of bacillary dysentery. Since its emergence in the late 1980s, the S. flexneri serotype 1c remains poorly…”
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A Perspective on the Strategy for Advancing ETVAX ® , An Anti-ETEC Diarrheal Disease Vaccine, into a Field Efficacy Trial in Gambian Children: Rationale, Challenges, Lessons Learned, and Future Directions by Hossain, M Jahangir, Svennerholm, Ann-Mari, Carlin, Nils, D'Alessandro, Umberto, Wierzba, Thomas F

“…For the first time in over 20 years, an Enterotoxigenic (ETEC) vaccine candidate, ETVAX , has advanced into a phase 2b field efficacy trial for children 6-18…”
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Efficacy of an Enterotoxigenic Escherichia coli (ETEC) Vaccine on the Incidence and Severity of Traveler's Diarrhea (TD): Evaluation of Alternative Endpoints and a TD Severity Score by Maier, Nicole, Grahek, Shannon L, Halpern, Jane, Restrepo, Suzanne, Troncoso, Felipe, Shimko, Janet, Torres, Olga, Belkind-Gerson, Jaime, Sack, David A, Svennerholm, Ann-Mari, Gustafsson, Björn, Sjöstrand, Björn, Carlin, Nils, Bourgeois, A Louis, Porter, Chad K

“…The efficacy of an Oral Whole Cell ETEC Vaccine (OEV) against Travelers' Diarrhea (TD) was reexamined using novel outcome and immunologic measures. More…”
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The nptA Gene of Vibrio cholerae Encodes a Functional Sodium-Dependent Phosphate Cotransporter Homologous to the Type II Cotransporters of Eukaryotes by Lebens, Michael, Lundquist, Patrik, Söderlund, Lars, Todorovic, Mirjana, Carlin, Nils I A

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Cross-reactivity and avidity of antibody responses induced in humans by the oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine ETVAX by Leach, Susannah, Lundgren, Anna, Carlin, Nils, Löfstrand, Madeleine, Svennerholm, Ann-Mari

“…Highlights • ETVAX induces cross-reactive antibodies that bind to related, non-vaccine colonisation factors. • ETVAX may protect against a wider range of ETEC…”
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Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study by Lundgren, Anna, Bourgeois, Louis, Carlin, Nils, Clements, John, Gustafsson, Björn, Hartford, Marianne, Holmgren, Jan, Petzold, Max, Walker, Richard, Svennerholm, Ann-Mari

“…Highlights • We have tested a new oral killed ETEC vaccine ± dmLT adjuvant in Swedish adults. • The vaccine contained E. coli bacteria overexpressing common…”
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Safety and immunogenicity of the oral, inactivated, enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi children and infants: a double-blind, randomised, placebo-controlled phase 1/2 trial by Qadri, Firdausi, Akhtar, Marjahan, Bhuiyan, Taufiqur R, Chowdhury, Mohiul I, Ahmed, Tasnuva, Rafique, Tanzeem A, Khan, Arifuzzaman, Rahman, Sadia I A, Khanam, Farhana, Lundgren, Anna, Wiklund, Gudrun, Kaim, Joanna, Löfstrand, Madeleine, Carlin, Nils, Bourgeois, A Louis, Maier, Nicole, Fix, Alan, Wierzba, Thomas, Walker, Richard I, Svennerholm, Ann-Mari

“…Enterotoxigenic Escherichia coli causes diarrhoea, leading to substantial mortality and morbidity in children, but no specific vaccine exists. This trial…”
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The Tailspike Protein of Shigella Phage Sf6 by Freiberg, Alexander, Morona, Renato, Van Den Bosch, Luisa, Jung, Christiane, Behlke, Joachim, Carlin, Nils, Seckler, Robert, Baxa, Ulrich

“…Bacteriophage Sf6 tailspike protein is functionally equivalent to the well characterized tailspike ofSalmonella phage P22, mediating attachment of the viral…”
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Evaluation of the safety and immunogenicity of the oral inactivated multivalent enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi adults in a double-blind, randomized, placebo-controlled Phase I trial using electrochemiluminescence and ELISA assays for immunogenicity analyses by Akhtar, Marjahan, Chowdhury, Mohiul I, Bhuiyan, Taufiqur R, Kaim, Joanna, Ahmed, Tasnuva, Rafique, Tanzeem A, Khan, Arifuzzaman, Rahman, Sadia I.A, Khanam, Farhana, Begum, Yasmin A, Sharif, Mir Z, Islam, Laila N, Carlin, Nils, Maier, Nicole, Fix, Alan, Wierzba, Thomas F, Walker, Richard I, Bourgeois, A. Louis, Svennerholm, Ann-Mari, Qadri, Firdausi, Lundgren, Anna

“…Highlights•The killed oral ETEC vaccine ETVAX ± dmLT adjuvant was safe in Bangladeshi adults. •All vaccinees responded to all 5 primary vaccine antigens in ALS…”
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Identification of Shigella flexneri subserotype 1c in rural Egypt by EL-GENDY, A, EL-GHORAB, N, LANE, E. M, ELYAZEED, R. A, CARLIN, N. I. A, MITRY, M. M, KAY, B. A, SAVARINO, S. J, PERUSKI, L. F

“…In a population-based study of diarrhea in rural, northern Egypt, 60 Shigella flexneri strains were identified, of which 10 could not be definitively…”
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Safety, tolerability, and immunogenicity of an oral inactivated ETEC vaccine (ETVAX®) with dmLT adjuvant in healthy adults and children in Zambia: An age descending randomised, placebo-controlled trial by Sukwa, Nsofwa, Mubanga, Cynthia, Hatyoka, Luiza M., Chilyabanyama, Obvious N., Chibuye, Mwelwa, Mundia, Samson, Munyinda, Masiliso, Kamuti, Ethel, Siyambango, Muyunda, Badiozzaman, Sharif, Bosomprah, Samuel, Carlin, Nils, Kaim, Joanna, Sjöstrand, Björn, Simuyandi, Michelo, Chilengi, Roma, Svennerholm, Ann-Mari

“…Enterotoxigenic Escherichia coli (ETEC) is an important cause of moderate to severe diarrhoea in children for which there is no licensed vaccine. We evaluated…”
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Cross-reactivity and avidity of antibody responses induced in humans by the oral inactivated multivalent enterotoxigenicEscherichia coli (ETEC) vaccine ETVAX by Leach, Susannah, Lundgren, Anna, Carlin, Nils, Löfstrand, Madeleine, Svennerholm, Ann-Mari

“…•ETVAX induces cross-reactive antibodies that bind to related, non-vaccine colonisation factors.•ETVAX may protect against a wider range of ETEC strains than…”
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Safety and immunogenicity of ETVAX®, an oral inactivated vaccine against enterotoxigenic Escherichia coli diarrhoea: a double-blinded, randomized, placebo-controlled trial amongst Finnish travellers to Benin, West Africa by Kantele, Anu, Riekkinen, Marianna, Jokiranta, T Sakari, Pakkanen, Sari H, Pietilä, Jukka-Pekka, Patjas, Anu, Eriksson, Mari, Khawaja, Tamim, Klemets, Peter, Marttinen, Kati, Siikamäki, Heli, Lundgren, Anna, Holmgren, Jan, Lissmats, Agneta, Carlin, Nils, Svennerholm, Ann-Mari

“…Abstract Background No licensed human vaccines are available against enterotoxigenic Escherichia coli (ETEC), a major diarrhoeal pathogen affecting children in…”
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Efficacy of an Enterotoxigenic IEscherichia coli/I : Evaluation of Alternative Endpoints and a TD Severity Score by Maier, Nicole, Grahek, Shannon L, Halpern, Jane, Restrepo, Suzanne, Troncoso, Felipe, Shimko, Janet, Torres, Olga, Belkind-Gerson, Jaime, Sack, David A, Svennerholm, Ann-Mari, Gustafsson, Björn, Sjöstrand, Björn, Carlin, Nils, Bourgeois, A. Louis, Porter, Chad K

“…The efficacy of an Oral Whole Cell ETEC Vaccine (OEV) against Travelers’ Diarrhea (TD) was reexamined using novel outcome and immunologic measures. More…”
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Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenicEscherichia coli(ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study by Lundgren, Anna, Bourgeois, Louis, Carlin, Nils, Clements, John, Gustafsson, Björn, Hartford, Marianne, Holmgren, Jan, Petzold, Max, Walker, Richard, Svennerholm, Ann-Mari

“…Background We have developed a new oral vaccine against enterotoxigenicEscherichia coli(ETEC), which is the most common cause of bacterial diarrhea in children…”
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Construction of a non-toxigenicEscherichia colioral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in mice by Tobias, Joshua, Svennerholm, Ann-Mari, Carlin, Nils IA, Lebens, Michael, Holmgren, Jan

“…Coli surface antigen 6 (CS6) is one of the most prevalent non-fimbrial colonization factors (CFs) of enterotoxigenicEscherichia coli(ETEC) bacteria, which are…”
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Structural studies of the O-antigenic polysaccharide of Escherichia coli O86, which possesses blood-group B activity by Andersson, M, Carlin, N, Leontein, K, Lindquist, U, Slettengren, K

“…The O-specific side-chains of the lipopolysaccharide from Escherichia coli O86:K2:H2 have been investigated using n.m.r. spectroscopy, methylation analysis,…”
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