Search Results - "Carles, Allison"

Targeting N -Methyl-d-Aspartate Receptors in Neurodegenerative Diseases by Carles, Allison, Freyssin, Aline, Perin-Dureau, Florent, Rubinstenn, Gilles, Maurice, Tangui

“…-methyl-d-aspartate receptors (NMDARs) are the main class of ionotropic receptors for the excitatory neurotransmitter glutamate. They play a crucial role in…”
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Convolamine, a tropane alkaloid extracted from Convolvulus plauricalis, is a potent sigma‐1 receptor‐positive modulator with cognitive and neuroprotective properties by Crouzier, Lucie, Meunier, Johann, Carles, Allison, Morilleau, Axelle, Vrigneau, Cassandre, Schmitt, Martine, Bourguignon, Jean‐Jacques, Delprat, Benjamin, Maurice, Tangui

“…Background and Aim By using an in vivo phenotypic screening assay in zebrafish, we identified Convolamine, a tropane alkaloid from Convulvus plauricalis, as a…”
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The selective butyrylcholinesterase inhibitor UW‐MD‐95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease by Carles, Allison, Hoffmann, Matthias, Scheiner, Matthias, Crouzier, Lucie, Bertrand‐Gaday, Christelle, Chatonnet, Arnaud, Decker, Michael, Maurice, Tangui

“…Aims Alzheimer's disease (AD) is a devastating dementia characterized by extracellular amyloid‐β (Aβ) protein aggregates and intracellular tau protein…”
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Fluoroethylnormemantine (FENM) shows synergistic protection in combination with a sigma-1 receptor agonist in a mouse model of Alzheimer's disease by Freyssin, Aline, Carles, Allison, Guehairia, Sarra, Rubinstenn, Gilles, Maurice, Tangui

“…Fluoroethylnormemantine (FENM) is a Memantine derivative with anti-amnesic and neuroprotective activities showed in the Aβ pharmacological mouse model of…”
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Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer’s Disease Mouse Model upon Irradiation by Scheiner, Matthias, Sink, Alexandra, Hoffmann, Matthias, Vrigneau, Cassandre, Endres, Erik, Carles, Allison, Sotriffer, Christoph, Maurice, Tangui, Decker, Michael

“…To develop tools to investigate the biological functions of butyrylcholinesterase (BChE) and the mechanisms by which BChE affects Alzheimer’s disease (AD), we…”
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Heptafluoroisobutyronitrile (C4F7N), a gas used for insulating and arc quenching in electrical switchgear, is neurotoxic in the mouse brain by Carles, Allison, Schlernitzauer, Audrey, Vignes, Michel, Cros, Gérard, Magous, Richard, Maurice, Tangui, Oiry, Catherine

“…Fluoronitrile gas (C4F7N, CAS number 42532-60-5) is one of the most promising candidates as insulating and/or breaking medium in high and medium voltage…”
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Exposure of R6/2 mice in an enriched environment augments P42 therapy efficacy on Huntington's disease progression by Couly, Simon, Carles, Allison, Denus, Morgane, Benigno-Anton, Lorraine, Maschat, Florence, Maurice, Tangui

“…Huntington's disease (HD) is due to a mutation in the gene encoding for Huntingtin protein generating polyQ domain extension. Mutant Htt (mHtt) leads to…”
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Targeting IN/I-Methyl-d-Aspartate Receptors in Neurodegenerative Diseases by Carles, Allison, Freyssin, Aline, Perin-Dureau, Florent, Rubinstenn, Gilles, Maurice, Tangui

“…N-methyl-d-aspartate receptors (NMDARs) are the main class of ionotropic receptors for the excitatory neurotransmitter glutamate. They play a crucial role in…”
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Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer’s Disease Mouse Model by Spatz, Philipp, Steinmüller, Sophie A. M., Tutov, Anna, Poeta, Eleonora, Morilleau, Axelle, Carles, Allison, Deventer, Marie H., Hofmann, Julian, Stove, Christophe P., Monti, Barbara, Maurice, Tangui, Decker, Michael

“…We present the synthesis and characterization of merged human butyrylcholinesterase (hBChE) inhibitor/cannabinoid receptor 2 (hCB2R) ligands for the treatment…”
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