Search Results - "Carlert, Sara"

In vitro models for the prediction of in vivo performance of oral dosage forms by Kostewicz, Edmund S., Abrahamsson, Bertil, Brewster, Marcus, Brouwers, Joachim, Butler, James, Carlert, Sara, Dickinson, Paul A., Dressman, Jennifer, Holm, René, Klein, Sandra, Mann, James, McAllister, Mark, Minekus, Mans, Muenster, Uwe, Müllertz, Anette, Verwei, Miriam, Vertzoni, Maria, Weitschies, Werner, Augustijns, Patrick

“…[Display omitted] Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is critical to efficient drug development…”
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Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug by Carlert, Sara, Pålsson, Anna, Hanisch, Gunilla, von Corswant, Christian, Nilsson, Catarina, Lindfors, Lennart, Lennernäs, Hans, Abrahamsson, Bertil

“…Purpose To investigate the prediction accuracy of in vitro and in vitro/in silico methods for in vivo intestinal precipitation of basic BCS class II drugs in…”
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A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts by Zöller, Laurin, Avdeef, Alex, Karlsson, Eva, Borde, Anders, Carlert, Sara, Saal, Christoph, Dressman, Jennifer

“…BACKGROUNDPharmaceutical salts of poorly soluble drugs typically dissolve faster than their corresponding free acid or base, resulting in supersaturation under…”
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Evaluation of the use of Classical Nucleation Theory for predicting intestinal crystalline precipitation of two weakly basic BSC class II drugs by Carlert, Sara, Lennernäs, Hans, Abrahamsson, Bertil

“…The aim of this work was to evaluate an in vitro–in silico approach for prediction of small intestinal crystalline precipitation and drug absorption of two…”
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Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid‐related orphan receptor γ agonist AZD0284 by Asimus, Sara, Palmér, Robert, Albayaty, Muna, Forsman, Henrik, Lundin, Christina, Olsson, Marita, Pehrson, Rikard, Mo, John, Russell, Muir, Carlert, Sara, Close, David, Keeling, David

“…Aims Retinoic acid‐related orphan receptor γ (RORγ), a master regulator of T‐helper 17 (Th17) cell function and differentiation, is an attractive target for…”
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A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts by Zöller, Laurin, Avdeef, Alex, Karlsson, Eva, Borde, Anders, Carlert, Sara, Saal, Christoph, Dressman, Jennifer

“…Pharmaceutical salts of poorly soluble drugs typically dissolve faster than their corresponding free acid or base, resulting in supersaturation under some…”
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Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary by Reppas, Christos, Kuentz, Martin, Bauer-Brandl, Annette, Carlert, Sara, Dallmann, André, Dietrich, Shirin, Dressman, Jennifer, Ejskjaer, Lotte, Frechen, Sebastian, Guidetti, Matteo, Holm, René, Holzem, Florentin Lukas, Karlsson, Εva, Kostewicz, Edmund, Panbachi, Shaida, Paulus, Felix, Senniksen, Malte Bøgh, Stillhart, Cordula, Turner, David B., Vertzoni, Maria, Vrenken, Paul, Zöller, Laurin, Griffin, Brendan T., O'Dwyer, Patrick J.

“…Due to the strong tendency towards poorly soluble drugs in modern development pipelines, enabling drug formulations such as amorphous solid dispersions,…”
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Biopharmaceutic Profiling of Salts to Improve Absorption of Poorly Soluble Basic Drugs by Tannergren, Christer, Karlsson, Eva, Sigfridsson, Kalle, Lindfors, Lennart, Ku, Angela, Polentarutti, Britta, Carlert, Sara

“…AZD1175 and AZD2207 are 2 highly lipophilic compounds with a significant risk of not achieving therapeutic plasma concentrations due to solubility-limited…”
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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies by Ahmad, Amais, Pepin, Xavier, Aarons, Leon, Wang, Yuya, Darwich, Adam S., Wood, J. Matthew, Tannergren, Christer, Karlsson, Eva, Patterson, Claire, Thörn, Helena, Ruston, Linette, Mattinson, Alex, Carlert, Sara, Berg, Staffan, Murphy, Donal, Engman, Helena, Laru, Johanna, Barker, Richard, Flanagan, Talia, Abrahamsson, Bertil, Budhdeo, Shanoo, Franek, Frans, Moir, Andrea, Hanisch, Gunilla, Pathak, Shriram M., Turner, David, Jamei, Masoud, Brown, Jonathan, Good, David, Vaidhyanathan, Shruthi, Jackson, Claire, Nicolas, Olivier, Beilles, Stephane, Nguefack, Jean-Flaubert, Louit, Guillaume, Henrion, Louis, Ollier, Celine, Boulu, Laurent, Xu, Christine, Heimbach, Tycho, Ren, Xiojun, Lin, Wen, Nguyen-Trung, Anh-Thu, Zhang, Jin, He, Handan, Wu, Fan, Bolger, Michael B., Mullin, James M., van Osdol, Bill, Szeto, Ke, Korjamo, Timo, Pappinen, Sari, Tuunainen, Johanna, Zhu, Wei, Xia, Binfeng, Daublain, Pierre, Wong, Suet, Varma, Manthena V.S., Modi, Sweta, Schäfer, Kerstin Julia, Schmid, Kartrin, Lloyd, Richard, Patel, Aarti, Tistaert, Christophe, Bevernage, Jan, Nguyen, Mai Anh, Lindley, David, Carr, Robert, Rostami-Hodjegan, Amin

“…[Display omitted] Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation…”
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In Vivo Dog Intestinal Precipitation of Mebendazole: A Basic BCS Class II Drug by Carlert, Sara, Åkesson, Pernilla, Jerndal, Gunilla, Lindfors, Lennart, Lennernäs, Hans, Abrahamsson, Bertil

“…The purpose of this study was to investigate in vivo intestinal precipitation of a model drug mebendazole, a basic BCS class II drug, using dogs with…”
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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results by Margolskee, Alison, Darwich, Adam S., Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson, Eva, Murphy, Dónal, Tannergren, Christer, Thörn, Helena, Yasin, Mohammed, Mazuir, Florent, Nicolas, Olivier, Ramusovic, Sergej, Xu, Christine, Pathak, Shriram M., Korjamo, Timo, Laru, Johanna, Malkki, Jussi, Pappinen, Sari, Tuunainen, Johanna, Dressman, Jennifer, Hansmann, Simone, Kostewicz, Edmund, He, Handan, Heimbach, Tycho, Wu, Fan, Hoft, Carolin, Laplanche, Loic, Pang, Yan, Bolger, Michael B., Huehn, Eva, Lukacova, Viera, Mullin, James M., Szeto, Ke X., Costales, Chester, Lin, Jian, McAllister, Mark, Modi, Sweta, Rotter, Charles, Varma, Manthena, Wong, Mei, Mitra, Amitava, Bevernage, Jan, Biewenga, Jeike, Van Peer, Achiel, Lloyd, Richard, Shardlow, Carole, Langguth, Peter, Mishenzon, Irina, Nguyen, Mai Anh, Brown, Jonathan, Lennernäs, Hans, Abrahamsson, Bertil

“…Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development…”
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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes by Darwich, Adam S., Margolskee, Alison, Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson, Eva, Murphy, Dónal, Tannergren, Christer, Thörn, Helena, Yasin, Mohammed, Mazuir, Florent, Nicolas, Olivier, Ramusovic, Sergej, Xu, Christine, Pathak, Shriram M., Korjamo, Timo, Laru, Johanna, Malkki, Jussi, Pappinen, Sari, Tuunainen, Johanna, Dressman, Jennifer, Hansmann, Simone, Kostewicz, Edmund, He, Handan, Heimbach, Tycho, Wu, Fan, Hoft, Carolin, Pang, Yan, Bolger, Michael B., Huehn, Eva, Lukacova, Viera, Mullin, James M., Szeto, Ke X., Costales, Chester, Lin, Jian, McAllister, Mark, Modi, Sweta, Rotter, Charles, Varma, Manthena, Wong, Mei, Mitra, Amitava, Bevernage, Jan, Biewenga, Jeike, Van Peer, Achiel, Lloyd, Richard, Shardlow, Carole, Langguth, Peter, Mishenzon, Irina, Nguyen, Mai Anh, Brown, Jonathan, Lennernäs, Hans, Abrahamsson, Bertil

“…Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine…”
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IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds by Margolskee, Alison, Darwich, Adam S., Pepin, Xavier, Pathak, Shriram M., Bolger, Michael B., Aarons, Leon, Rostami-Hodjegan, Amin, Angstenberger, Jonas, Graf, Franziska, Laplanche, Loic, Müller, Thomas, Carlert, Sara, Daga, Pankaj, Murphy, Dónal, Tannergren, Christer, Yasin, Mohammed, Greschat-Schade, Susanne, Mück, Wolfgang, Muenster, Uwe, van der Mey, Dorina, Frank, Kerstin Julia, Lloyd, Richard, Adriaenssen, Lieve, Bevernage, Jan, De Zwart, Loeckie, Swerts, Dominique, Tistaert, Christophe, Van Den Bergh, An, Van Peer, Achiel, Beato, Stefania, Nguyen-Trung, Anh-Thu, Bennett, Joanne, McAllister, Mark, Wong, Mei, Zane, Patricia, Ollier, Céline, Vicat, Pascale, Kolhmann, Markus, Marker, Alexander, Brun, Priscilla, Mazuir, Florent, Beilles, Stéphane, Venczel, Marta, Boulenc, Xavier, Loos, Petra, Lennernäs, Hans, Abrahamsson, Bertil

“…Predicting oral bioavailability (Foral) is of importance for estimating systemic exposure of orally administered drugs. Physiologically-based pharmacokinetic…”
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Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method by Plum, Jakob, Madsen, Cecilie M, Teleki, Alexandra, Bevernage, Jan, da Costa Mathews, Claudia, Karlsson, Eva M, Carlert, Sara, Holm, Rene, Müller, Thomas, Matthews, Wayne, Sayers, Alice, Ojala, Krista, Tsinsman, Konstantin, Lingamaneni, Ram, Bergström, Christel AS, Rades, Thomas, Müllertz, Anette

“…The high number of poorly water-soluble compounds in drug development has increased the need for enabling formulations to improve oral bioavailability. One…”
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