Search Results - "Cario, Gunnar"

BCR-ABL1-like acute lymphoblastic leukemia in childhood and targeted therapy by Cario, Gunnar, Leoni, Veronica, Conter, Valentino, Baruchel, André, Schrappe, Martin, Biondi, Andrea

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Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia by Lilljebjörn, Henrik, Henningsson, Rasmus, Hyrenius-Wittsten, Axel, Olsson, Linda, Orsmark-Pietras, Christina, von Palffy, Sofia, Askmyr, Maria, Rissler, Marianne, Schrappe, Martin, Cario, Gunnar, Castor, Anders, Pronk, Cornelis J. H., Behrendtz, Mikael, Mitelman, Felix, Johansson, Bertil, Paulsson, Kajsa, Andersson, Anna K., Fontes, Magnus, Fioretos, Thoas

“…Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion gene landscape in a consecutive series of 195 paediatric B-cell…”
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Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia by Abdelrasoul, Hend, Vadakumchery, Anila, Werner, Markus, Lenk, Lennart, Khadour, Ahmad, Young, Marc, El Ayoubi, Omar, Vogiatzi, Fotini, Krämer, Markus, Schmid, Vera, Chen, Zhengshan, Yousafzai, Yasar, Cario, Gunnar, Schrappe, Martin, Müschen, Markus, Halsey, Christina, Mulaw, Medhanie A., Schewe, Denis M., Hobeika, Elias, Alsadeq, Ameera, Jumaa, Hassan

“…Ph + acute lymphoblastic leukemia (ALL) is characterized by the expression of an oncogenic fusion kinase termed BCR-ABL1. Here, we show that interleukin 7…”
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Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL by McComb, Scott, Aguadé-Gorgorió, Júlia, Harder, Lena, Marovca, Blerim, Cario, Gunnar, Eckert, Cornelia, Schrappe, Martin, Stanulla, Martin, von Stackelberg, Arend, Bourquin, Jean-Pierre, Bornhauser, Beat C

“…More precise treatment strategies are urgently needed to decrease toxicity and improve outcomes for treatment-refractory leukemia. We used ex vivo drug…”
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Reduced-Intensity Delayed Intensification in Standard-Risk Pediatric Acute Lymphoblastic Leukemia Defined by Undetectable Minimal Residual Disease: Results of an International Randomized Trial (AIEOP-BFM ALL 2000) by Schrappe, Martin, Bleckmann, Kirsten, Zimmermann, Martin, Biondi, Andrea, Möricke, Anja, Locatelli, Franco, Cario, Gunnar, Rizzari, Carmelo, Attarbaschi, Andishe, Valsecchi, Maria Grazia, Bartram, Claus R, Barisone, Elena, Niggli, Felix, Niemeyer, Charlotte, Testi, Anna Maria, Mann, Georg, Ziino, Ottavio, Schäfer, Beat, Panzer-Grümayer, Renate, Beier, Rita, Parasole, Rosanna, Göhring, Gudrun, Ludwig, Wolf-Dieter, Casale, Fiorina, Schlegel, Paul-Gerhardt, Basso, Giuseppe, Conter, Valentino

“…Purpose Delayed intensification (DI) is an integral part of treatment of childhood acute lymphoblastic leukemia (ALL), but it is associated with relevant…”
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Durable remissions in TCF3-HLF positive acute lymphoblastic leukemia with blinatumomab and stem cell transplantation by Mouttet, Brice, Vinti, Luciana, Ancliff, Philip, Bodmer, Nicole, Brethon, Benoît, Cario, Gunnar, Chen-Santel, Christiane, Elitzur, Sarah, Hazar, Volkan, Kunz, Joachim, Möricke, Anja, Stein, Jerry, Vora, Ajay, Yaman, Yöntem, Schrappe, Martin, Anak, Sema, Baruche, André, Locatelli, Franco, von Stackelberg, Arend, Stanulla, Martin, Bourquin, Jean-Pierre

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Deciphering the molecular complexity of the IKZF1plus genomic profile using Optical Genome Mapping by Lühmann, Jonathan L., Zimmermann, Martin, Hofmann, Winfried, Bergmann, Anke K., Möricke, Anja, Cario, Gunnar, Schrappe, Martin, Schlegelberger, Brigitte, Stanulla, Martin, Steinemann, Doris

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Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance by Bonapace, Laura, Bornhauser, Beat C, Schmitz, Maike, Cario, Gunnar, Ziegler, Urs, Niggli, Felix K, Schäfer, Beat W, Schrappe, Martin, Stanulla, Martin, Bourquin, Jean-Pierre

“…In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor outcome in children with acute lymphoblastic…”
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Hematopoietic stem cell transplantation in children and adolescents with GATA2-related myelodysplastic syndrome by Bortnick, Rachel, Wlodarski, Marcin, de Haas, Valerie, De Moerloose, Barbara, Dworzak, Michael, Hasle, Henrik, Masetti, Riccardo, Starý, Jan, Turkiewicz, Dominik, Ussowicz, Marek, Kozyra, Emilia, Albert, Michael, Bader, Peter, Bordon, Victoria, Cario, Gunnar, Beier, Rita, Schulte, Johannes, Bresters, Dorine, Müller, Ingo, Pichler, Herbert, Sedlacek, Petr, Sauer, Martin G., Zecca, Marco, Göhring, Gudrun, Yoshimi, Ayami, Noellke, Peter, Erlacher, Miriam, Locatelli, Franco, Niemeyer, Charlotte M., Strahm, Brigitte

“…GATA2 deficiency is a heterogeneous multi-system disorder characterized by a high risk of developing myelodysplastic syndrome (MDS) and myeloid leukemia. We…”
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Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium by Buchmann, Swantje, Schrappe, Martin, Baruchel, Andre, Biondi, Andrea, Borowitz, Michael, Campbell, Myriam, Cario, Gunnar, Cazzaniga, Giovanni, Escherich, Gabriele, Harrison, Christine J., Heyman, Mats, Hunger, Stephen P., Kiss, Csongor, Liu, Hsi-Che, Locatelli, Franco, Loh, Mignon L., Manabe, Atsushi, Mann, Georg, Pieters, Rob, Pui, Ching-Hon, Rives, Susana, Schmiegelow, Kjeld, Silverman, Lewis B., Stary, Jan, Vora, Ajay, Brown, Patrick

“…Comparison of treatment strategies in de novo pediatric acute lymphoblastic leukemia (ALL) requires standardized measures of efficacy. Key parameters that…”
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The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system by Alsadeq, Ameera, Fedders, Henning, Vokuhl, Christian, Belau, Nele M, Zimmermann, Martin, Wirbelauer, Tim, Spielberg, Steffi, Vossen-Gajcy, Michaela, Cario, Gunnar, Schrappe, Martin, Schewe, Denis M

“…Central nervous system infiltration and relapse are poorly understood in childhood acute lymphoblastic leukemia. We examined the role of zeta-chain-associated…”
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Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial by Attarbaschi, Andishe, Mann, Georg, Zimmermann, Martin, Bader, Peter, Barisone, Elena, Basso, Giuseppe, Biondi, Andrea, Cario, Gunnar, Cazzaniga, Gianni, Colombini, Antonella, Flotho, Christian, Kuhlen, Michaela, Lang, Peter, Lauten, Melchior, Linderkamp, Christin, Locatelli, Franco, Lo Nigro, Luca, Möricke, Anja, Niggli, Felix, Panzer-Grümayer, Renate, Parasole, Rosanna, Peters, Christina, Caterina Putti, Maria, Rizzari, Carmelo, Suttorp, Meinolf, Valsecchi, Maria Grazia, Conter, Valentino, Schrappe, Martin

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Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia by Stanulla, Martin, Schaeffeler, Elke, Möricke, Anja, Buchmann, Swantje, Zimmermann, Martin, Igel, Svitlana, Schmiegelow, Kjeld, Flotho, Christian, Hartmann, Hans, Illsinger, Sabine, Sauerbrey, Axel, Junk, Stefanie V., Schütte, Peter, Hinze, Laura, Lauten, Melchior, Modlich, Simon, Kolb, Reinhard, Rossig, Claudia, Schwabe, Georg, Gnekow, Astrid K., Fleischhack, Gudrun, Schlegel, Paul Gerhard, Schünemann, Holger J., Kratz, Christian P., Cario, Gunnar, Schrappe, Martin, Schwab, Matthias

“…Long-term treatment with 6-thioguanine (6-TG) for pediatric acute lymphoblastic leukemia (ALL) is associated with high rates of hepatic sinusoidal obstruction…”
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No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study by Conter, Valentino, Valsecchi, Maria Grazia, De Lorenzo, Paola, Gandemer, Virginie, Heyman, Mats, Saha, Vaskar, Diaz, Paulina, Li, Chi-Kong, Attarbaschi, Andishe, Escherich, Gabriele, Stary, Jan, Schrappe, Martin, Pieters, Rob, Cario, Gunnar, Biondi, Andrea

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NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD + -sirtuin-1-dependent pathway by Skokowa, Julia, Welte, Karl, Lan, Dan, Thakur, Basant Kumar, Wang, Fei, Gupta, Kshama, Cario, Gunnar, Brechlin, Annette Müller, Schambach, Axel, Hinrichsen, Lars, Meyer, Gustav, Gaestel, Matthias, Stanulla, Martin, Tong, Qiang

“…In this report, Skokowa et al . delineate a new molecular pathway by which synthesis of the metabolite NAD + through the action of the enzyme NAMPT promotes…”
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Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome by Schwartzman, Omer, Savino, Angela Maria, Gombert, Michael, Palmi, Chiara, Cario, Gunnar, Schrappe, Martin, Eckert, Cornelia, von Stackelberg, Arend, Huang, Jin-Yan, Hameiri-Grossman, Michal, Avigad, Smadar, te Kronnie, Geertruy, Geron, Ifat, Birger, Yehudit, Rein, Avigail, Zarfati, Giulia, Fischer, Ute, Mukamel, Zohar, Stanulla, Martin, Biondi, Andrea, Cazzaniga, Giovanni, Vetere, Amedeo, Wagner, Bridget K., Chen, Zhu, Chen, Sai-Juan, Tanay, Amos, Borkhardt, Arndt, Izraeli, Shai

“…Children with Down syndrome (DS) are prone to development of high-risk B-cell precursor ALL (DS-ALL), which differs genetically from most sporadic pediatric…”
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Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols by Cario, Gunnar, Leoni, Veronica, Conter, Valentino, Attarbaschi, Andishe, Zaliova, Marketa, Sramkova, Lucie, Cazzaniga, Gianni, Fazio, Grazia, Sutton, Rosemary, Elitzur, Sarah, Izraeli, Shai, Lauten, Melchior, Locatelli, Franco, Basso, Giuseppe, Buldini, Barbara, Bergmann, Anke K, Lentes, Jana, Steinemann, Doris, Göhring, Gudrun, Schlegelberger, Brigitte, Haas, Oskar A, Schewe, Denis, Buchmann, Swantje, Moericke, Anja, White, Deborah, Revesz, Tamas, Stanulla, Martin, Mann, Georg, Bodmer, Nicole, Arad-Cohen, Nira, Zuna, Jan, Valsecchi, Maria Grazia, Zimmermann, Martin, Schrappe, Martin, Biondi, Andrea

“…ABL-class fusions other than characterize around 2-3% of precursor B-cell acute lymphoblastic leukemia. Case series indicated that patients suffering from…”
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Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia by Schieck, Maximilian, Lentes, Jana, Thomay, Kathrin, Hofmann, Winfried, Behrens, Yvonne Lisa, Hagedorn, Maike, Ebersold, Juliane, Davenport, Colin F., Fazio, Grazia, Möricke, Anja, Buchmann, Swantje, Alten, Julia, Cario, Gunnar, Schrappe, Martin, Bergmann, Anke Katharina, Stanulla, Martin, Steinemann, Doris, Schlegelberger, Brigitte, Cazzaniga, Giovanni, Göhring, Gudrun

“…Risk-adapted therapy has significantly contributed to improved survival rates in pediatric acute lymphoblastic leukemia (ALL) and reliable detection of…”
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Approaches for bridging therapy prior to chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic B-lineage leukaemia in children and young adults by Feuchtinger, Tobias, Bader, Peter, Subklewe, Marion, Breidenbach, Maike, Willier, Semjon, Metzler, Markus, Gökbuget, Nicola, Hauer, Julia, Müller, Fabian, Schlegel, Paul-Gerhardt, Frühwald, Michael, Schmid, Christoph, Troeger, Anja, Baldus, Claudia, Meisel, Roland, Künkele, Annette, Topp, Max, Bourquin, Jean-Pierre, Cario, Gunnar, Von Stackelberg, Arend, Peters, Christina

“…The ongoing development of immunotherapies, including chimeric antigen receptor (CAR) T cells, has revolutionized cancer treatment. In paediatric…”
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Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia by Heilmann, Janina, Vieth, Simon, Möricke, Anja, Attarbaschi, Andishe, Barbaric, Draga, Bodmer, Nicole, Colombini, Antonella, Dalla-Pozza, Luciano, Elitzur, Sarah, Izraeli, Shai, Mann, Georg, Niggli, Felix, Silvestri, Daniela, Stary, Jan, Rizzari, Carmelo, Valsecchi, Maria Grazia, Zapotocka, Ester, Zimmermann, Martin, Cario, Gunnar, Schrappe, Martin, Conter, Valentino

“…Although initial central nervous system (CNS) involvement is rarely detected in childhood acute lymphoblastic leukemia (ALL), risk-adapted CNS-directed therapy…”
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