Search Results - "Carine Poussin"

Interrogating the microbiome: experimental and computational considerations in support of study reproducibility by Poussin, Carine, Sierro, Nicolas, Boué, Stéphanie, Battey, James, Scotti, Elena, Belcastro, Vincenzo, Peitsch, Manuel C., Ivanov, Nikolai V., Hoeng, Julia

“…[Display omitted] •Growing evidence indicates that the microbiome plays an important role in health and disease.•Reliable and meaningful scientific conclusions…”
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Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers by Mathis, Carole, Poussin, Carine, Weisensee, Dirk, Gebel, Stephan, Hengstermann, Arnd, Sewer, Alain, Belcastro, Vincenzo, Xiang, Yang, Ansari, Sam, Wagner, Sandra, Hoeng, Julia, Peitsch, Manuel C

“…Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms,…”
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Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop by CORNU, Marion, YANG, Jiang-Yan, JACCARD, Evrim, POUSSIN, Carine, WIDMANN, Christian, THORENS, Bernard

“…Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop Marion Cornu 1 , Jiang-Yan Yang…”
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Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge by Poussin, Carine, Khachatryan, Lusine, Sierro, Nicolas, Narsapuram, Vijay Kumar, Meyer, Fernando, Kaikala, Vinay, Chawla, Vandna, Muppirala, Usha, Kumar, Sunil, Belcastro, Vincenzo, Battey, James N. D, Scotti, Elena, Boué, Stéphanie, McHardy, Alice C, Peitsch, Manuel C, Ivanov, Nikolai V, Hoeng, Julia

“…Abstract Background Selection of optimal computational strategies for analyzing metagenomics data is a decisive step in determining the microbial composition…”
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Blood and urine multi-omics analysis of the impact of e-vaping, smoking, and cessation: from exposome to molecular responses by Poussin, Carine, Titz, Bjoern, Xiang, Yang, Baglia, Laurel, Berg, Rachel, Bornand, David, Choukrallah, Mohammed-Amin, Curran, Timothy, Dijon, Sophie, Dossin, Eric, Dulize, Remi, Etter, Doris, Fatarova, Maria, Medlin, Loyse Felber, Haiduc, Adrian, Kishazi, Edina, Kolli, Aditya R., Kondylis, Athanasios, Kottelat, Emmanuel, Laszlo, Csaba, Lavrynenko, Oksana, Eb-Levadoux, Yvan, Nury, Catherine, Peric, Dariusz, Rizza, Melissa, Schneider, Thomas, Guedj, Emmanuel, Calvino, Florian, Sierro, Nicolas, Guy, Philippe, Ivanov, Nikolai V., Picavet, Patrick, Spinelli, Sherry, Hoeng, Julia, Peitsch, Manuel C.

“…Cigarette smoking is a major preventable cause of morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to…”
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Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro by Poussin, Carine, van der Toorn, Marco, Scheuner, Sophie, Piault, Romain, Kondylis, Athanasios, Savioz, Rebecca, Dulize, Rémi, Peric, Dariusz, Guedj, Emmanuel, Maranzano, Fabio, Merg, Celine, Morelli, Moran, Egesipe, Anne-Laure, Johne, Stéphanie, Majeed, Shoaib, Pak, Claudius, Schneider, Thomas, Schlage, Walter K., Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Aging and smoking are major risk factors for cardiovascular diseases (CVD). Our in vitro study compared, in the context of aging, the effects of the aerosol of…”
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Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge by Rhrissorrakrai, Kahn, Belcastro, Vincenzo, Bilal, Erhan, Norel, Raquel, Poussin, Carine, Mathis, Carole, Dulize, Rémi H J, Ivanov, Nikolai V, Alexopoulos, Leonidas, Rice, J Jeremy, Peitsch, Manuel C, Stolovitzky, Gustavo, Meyer, Pablo, Hoeng, Julia

“…Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormones is an essential question in biomedicine. Very often, however, this…”
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Results and lessons learned from the sbv IMPROVER metagenomics diagnostics for inflammatory bowel disease challenge by Khachatryan, Lusine, Xiang, Yang, Ivanov, Artem, Glaab, Enrico, Graham, Garrett, Granata, Ilaria, Giordano, Maurizio, Maddalena, Lucia, Piccirillo, Marina, Manipur, Ichcha, Baruzzo, Giacomo, Cappellato, Marco, Avot, Batiste, Stan, Adrian, Battey, James, Lo Sasso, Giuseppe, Boue, Stephanie, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia, Falquet, Laurent, Di Camillo, Barbara, Guarracino, Mario R., Ulyantsev, Vladimir, Sierro, Nicolas, Poussin, Carine

“…A growing body of evidence links gut microbiota changes with inflammatory bowel disease (IBD), raising the potential benefit of exploiting metagenomics data…”
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Systems biology reveals anatabine to be an NRF2 activator by Messinis, Dimitris E., Poussin, Carine, Latino, Diogo A. R. S., Eb-Levadoux, Yvan, Dulize, Remi, Peric, Dariusz, Guedj, Emmanuel, Titz, Bjoern, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Anatabine, an alkaloid present in plants of the So lanaceae family (including tobacco and eggplant), has been shown to ameliorate chronic inflammatory…”
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Verification of systems biology research in the age of collaborative competition by Poussin, Carine

“…Doc number: P48…”
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Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14 by Klinger, Sonia, Poussin, Carine, Debril, Marie-Bernard, Dolci, Wanda, Halban, Philippe A, Thorens, Bernard

“…Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14 Sonia Klinger 1 ,…”
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Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case by Schlage, Walter K., Titz, Bjoern, Iskandar, Anita, Poussin, Carine, Van der Toorn, Marco, Wong, Ee Tsin, Pratte, Pascal, Maeder, Serge, Schaller, Jean-Pierre, Pospisil, Pavel, Boue, Stephanie, Vuillaume, Grégory, Leroy, Patrice, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…[Display omitted] •Heated tobacco products tested for reduced exposure and reduced risk properties.•Bridging opportunities for nonclinical results from two…”
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Transcript Profiling Suggests That Differential Metabolic Adaptation of Mice to a High Fat Diet Is Associated with Changes in Liver to Muscle Lipid Fluxes by de Fourmestraux, Valérie, Neubauer, Heike, Poussin, Carine, Farmer, Pierre, Falquet, Laurent, Burcelin, Rémy, Delorenzi, Mauro, Thorens, Bernard

“…Genetically homogenous C57Bl/6 mice display differential metabolic adaptation when fed a high fat diet for 9 months. Most become obese and diabetic, but a…”
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Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice by Poussin, Carine, Hall, Diana, Minehira, Kaori, Galzin, Anne-Marie, Tarussio, David, Thorens, Bernard

“…The visceral (VAT) and subcutaneous (SCAT) adipose tissues play different roles in physiology and obesity. The molecular mechanisms underlying their expansion…”
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A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro by Mathis, Carole, Gebel, Stephan, Poussin, Carine, Belcastro, Vincenzo, Sewer, Alain, Weisensee, Dirk, Hengstermann, Arnd, Ansari, Sam, Wagner, Sandra, Peitsch, Manuel C., Hoeng, Julia

“…To establish a relevant in vitro model for systems toxicology-based mechanistic assessment of environmental stressors such as cigarette smoke (CS), we exposed…”
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On Crowd-verification of Biological Networks by Ansari, Sam, Binder, Jean, Boue, Stephanie, Di Fabio, Anselmo, Hayes, William, Hoeng, Julia, Iskandar, Anita, Kleiman, Robin, Norel, Raquel, O'neel, Bruce, Peitsch, Manuel C., Poussin, Carine, Pratt, Dexter, Rhrissorrakrai, Kahn, Schlage, Walter K., Stolovitzky, Gustavo, Talikka, Marja

“…Biological networks with a structured syntax are a powerful way of representing biological information generated from high density data; however, they can…”
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3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology_suppl by Poussin, Carine

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Systematic Verification of Upstream Regulators of a Computable Cellular Proliferation Network Model on Non-Diseased Lung Cells Using a Dedicated Dataset by Belcastro, Vincenzo, Poussin, Carine, Gebel, Stephan, Mathis, Carole, Schlage, Walter K., Lichtner, Rosemarie B., Quadt-Humme, Sibille, Wagner, Sandra, Hoeng, Julia, Peitsch, Manuel C.

“…We recently constructed a computable cell proliferation network (CPN) model focused on lung tissue to unravel complex biological processes and their…”
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CD14-dependent Endotoxin Internalization via a Macropinocytic Pathway by Poussin, Carine, Foti, Michelangelo, Carpentier, Jean-Louis, Pugin, Jérôme

“…Gram-negative bacterial endotoxin (a lipopolysaccharide (LPS)) specifically binds to CD14, a glycosylphosphatidyl inositol (GPI)-anchored surface myeloid…”
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Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells by Poussin, Carine, Laurent, Alexandra, Peitsch, Manuel C, Hoeng, Julia, De Leon, Hector

“…Highlights • Cigarette smoke (CS) progressively favors the development of atherosclerosis. • Modified risk tobacco products (MRTPs) are developed to reduce…”
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