Search Results - "Carina Herbst"

Deep learning of HIV field-based rapid tests by Turbé, Valérian, Herbst, Carina, Mngomezulu, Thobeka, Meshkinfamfard, Sepehr, Dlamini, Nondumiso, Mhlongo, Thembani, Smit, Theresa, Cherepanova, Valeriia, Shimada, Koki, Budd, Jobie, Arsenov, Nestor, Gray, Steven, Pillay, Deenan, Herbst, Kobus, Shahmanesh, Maryam, McKendry, Rachel A.

“…Although deep learning algorithms show increasing promise for disease diagnosis, their use with rapid diagnostic tests performed in the field has not been…”
Get full text

Prevalence of Curable Sexually Transmitted Infections in a Population-Representative Sample of Young Adults in a High HIV Incidence Area in South Africa by Jarolimova, Jana, Chidumwa, Glory, Chimbindi, Natsayi, Okesola, Nonhlanhla, Dreyer, Jaco, Smit, Theresa, Seeley, Janet, Harling, Guy, Copas, Andrew, Baisley, Kathy, Shahmanesh, Maryam, Herbst, Carina, McGrath, Nuala, Zuma, Thembelihle, Khoza, Thandeka, Behuhuma, Ngundu, Bassett, Ingrid V, Sherr, Lorraine

“…Recent population-representative estimates of sexually transmitted infection (STI) prevalence in high HIV burden areas in southern Africa are limited. We…”
Get full text

Thetha Nami: participatory development of a peer-navigator intervention to deliver biosocial HIV prevention for adolescents and youth in rural South Africa by Shahmanesh, Maryam, Okesola, Nonhlanhla, Chimbindi, Natsayi, Zuma, Thembelihle, Mdluli, Sakhile, Mthiyane, Nondumiso, Adeagbo, Oluwafemi, Dreyer, Jaco, Herbst, Carina, McGrath, Nuala, Harling, Guy, Sherr, Lorraine, Seeley, Janet

“…Despite effective biomedical tools, HIV remains the largest cause of morbidity/mortality in South Africa - especially among adolescents and young people. We…”
Get full text

Process evaluation of peer-to-peer delivery of HIV self-testing and sexual health information to support HIV prevention among youth in rural KwaZulu-Natal, South Africa: qualitative analysis by Adeagbo, Oluwafemi Atanda, Seeley, Janet, Gumede, Dumsani, Xulu, Sibongiseni, Dlamini, Nondumiso, Luthuli, Manono, Dreyer, Jaco, Herbst, Carina, Cowan, F, Chimbindi, Natsayi, Hatzold, Karin, Okesola, Nonhlanhla, Johnson, Cheryl, Harling, Guy, Subedar, Hasina, Sherr, Lorraine, McGrath, Nuala, Corbett, Liz, Shahmanesh, Maryam

“…ObjectivePeer-to-peer (PTP) HIV self-testing (HIVST) distribution models can increase uptake of HIV testing and potentially create demand for HIV treatment and…”
Get full text

The impact of continuous quality improvement on coverage of antenatal HIV care tests in rural South Africa: Results of a stepped-wedge cluster-randomised controlled implementation trial by Yapa, H Manisha, De Neve, Jan-Walter, Chetty, Terusha, Herbst, Carina, Post, Frank A, Jiamsakul, Awachana, Geldsetzer, Pascal, Harling, Guy, Dhlomo-Mphatswe, Wendy, Moshabela, Mosa, Matthews, Philippa, Ogbuoji, Osondu, Tanser, Frank, Gareta, Dickman, Herbst, Kobus, Pillay, Deenan, Wyke, Sally, Bärnighausen, Till

“…Evidence for the effectiveness of continuous quality improvement (CQI) in resource-poor settings is very limited. We aimed to establish the effects of CQI on…”
Get full text

A mixed methods process evaluation: understanding the implementation and delivery of HIV prevention services integrated within sexual reproductive health (SRH) with or without peer support amongst adolescents and young adults in rural KwaZulu-Natal, South Africa by Zuma, Thembelihle, Busang, Jacob, Hlongwane, Sphesihle, Chidumwa, Glory, Gumede, Dumsani, Luthuli, Manono, Dreyer, Jaco, Herbst, Carina, Okesola, Nonhlanhla, Chimbindi, Natsayi, McGrath, Nuala, Sherr, Lorraine, Seeley, Janet, Shahmanesh, Maryam

“…Combination prevention interventions, when integrated with community-based support, have been shown to be particularly beneficial to adolescent and young…”
Get full text

Thetha Nami ngithethe nawe (Let's Talk): a stepped-wedge cluster randomised trial of social mobilisation by peer navigators into community-based sexual health and HIV care, including pre-exposure prophylaxis (PrEP), to reduce sexually transmissible HIV amongst young people in rural KwaZulu-Natal, South Africa by Busang, Jacob, Zuma, Thembelihle, Herbst, Carina, Okesola, Nonhlanhla, Chimbindi, Natsayi, Dreyer, Jaco, Mtshali, Nelisiwe, Smit, Theresa, Ngubane, Samkelisiwe, Hlongwane, Siphesihle, Gumede, Dumsani, Jalazi, Ashley, Mdluli, Simphiweyenkosi, Bird, Kristien, Msane, Sithembile, Danisa, Priscilla, Hanekom, Willem, Lebina, Limakatso, Behuhuma, Ngundu, Hendrickson, Cheryl, Miot, Jacqui, Seeley, Janet, Harling, Guy, Jarolimova, Jana, Sherr, Lorraine, Copas, Andrew, Baisley, Kathy, Shahmanesh, Maryam

“…Antiretroviral therapy (ART) through universal test and treat (UTT) and HIV pre-exposure prophylaxis (PrEP) substantially reduces HIV-related mortality and…”
Get full text

Isisekelo Sempilo study protocol for the effectiveness of HIV prevention embedded in sexual health with or without peer navigator support (Thetha Nami) to reduce prevalence of transmissible HIV amongst adolescents and young adults in rural KwaZulu-Natal: a 2 × 2 factorial randomised controlled trial by Chidumwa, Glory, Chimbindi, Natsayi, Herbst, Carina, Okeselo, Nonhlanhla, Dreyer, Jaco, Zuma, Thembelihle, Smith, Theresa, Molina, Jean-Michel, Khoza, Thandeka, McGrath, Nuala, Seeley, Janet, Pillay, Deenan, Tanser, Frank, Harling, Guy, Sherr, Lorraine, Copas, Andrew, Baisley, Kathy, Shahmanesh, Maryam

“…Antiretroviral therapy (ART) through universal test and treat (UTT) and HIV pre-exposure prophylaxis (PrEP) substantially reduces HIV-related mortality,…”
Get full text

The MONARCH intervention to enhance the quality of antenatal and postnatal primary health services in rural South Africa: protocol for a stepped-wedge cluster-randomised controlled trial by Chetty, Terusha, Yapa, H Manisha N, Herbst, Carina, Geldsetzer, Pascal, Naidu, Kevindra K, De Neve, Jan-Walter, Herbst, Kobus, Matthews, Philippa, Pillay, Deenan, Wyke, Sally, Bärnighausen, Till

“…Gaps in maternal and child health services can slow progress towards achieving the Sustainable Development Goals. The Management and Optimization of Nutrition,…”
Get full text

A Continuous Quality Improvement Intervention to Improve Antenatal HIV Care Testing in Rural South Africa: Evaluation of Implementation in a Real-World Setting by Yapa, H Manisha, Dhlomo-Mphatswe, Wendy, Moshabela, Mosa, De Neve, Jan-Walter, Herbst, Carina, Jiamsakul, Awachana, Petoumenos, Kathy, Post, Frank A, Pillay, Deenan, Bärnighausen, Till, Wyke, Sally

“…We evaluated continuous quality improvement (CQI) targeting antenatal HIV care quality in rural South Africa using a stepped-wedge cluster-randomised…”
Get full text

Adaptation and pre-test of a shortened Stepping Stones and Creating Futures intervention focused on HIV for young men in rural South Africa by Gibbs, Andrew, Gumede, Dumsani, Adeagbo, Oluwafemi, Sikweyiya, Yandisa, Chirwa, Esnat, Mkhwanazi, Smanga, Luthuli, Manono, Xulu, Zakhele, Herbst, Carina, Zuma, Thembelihle, Hlongwane, Siphesihle, Okesola, Nonhlanhla, Dreyer, Jaco, Khaula, Sivuyile, Washington, Laura, Shahmanesh, Maryam

“…Men's engagement in HIV prevention and treatment is suboptimal, including in South Africa. We sought to address this through adapting an evidence-based…”
Get full text

Infant feeding knowledge and practice vary by maternal HIV status: a nested cohort study in rural South Africa by Yapa, H. Manisha, Drayne, Róisín, Klein, Nigel, De Neve, Jan-Walter, Petoumenos, Kathy, Jiamsakul, Awachana, Herbst, Carina, Pillay, Deenan, Post, Frank A, Bärnighausen, Till

“…Background We investigate whether correct infant feeding knowledge and practice differ by maternal HIV status in an era of evolving clinical guidelines in…”
Get full text

Assessment of fragment docking and scoring with the endothiapepsin model system by Herbst, Carina, Endres, Sara, Würz, Rebecca, Sotriffer, Christoph

“…Fragment‐based screening has become indispensable in drug discovery. Yet, the weak binding affinities of these small molecules still represent a challenge for…”
Get full text

Exploring People's Candidacy for Mobile Health-Supported HIV Testing and Care Services in Rural KwaZulu-Natal, South Africa: Qualitative Study by Adeagbo, Oluwafemi, Herbst, Carina, Blandford, Ann, McKendry, Rachel, Estcourt, Claudia, Seeley, Janet, Shahmanesh, Maryam

“…The use of mobile communication technologies (mHealth: mobile health) in chronic disease management has grown significantly over the years. mHealth…”
Get full text

The association of exposure to DREAMS on sexually acquiring or transmitting HIV amongst adolescent girls and young women living in rural South Africa by Mthiyane, Nondumiso, Baisley, Kathy, Chimbindi, Natsayi, Zuma, Thembelihle, Okesola, Nonhlanhla, Dreyer, Jaco, Herbst, Carina, Smit, Theresa, Danaviah, Siva, McGrath, Nuala, Harling, Guy, Sherr, Lorraine, Seeley, Janet, Floyd, Sian, Birdthistle, Isolde, Shahmanesh, Maryam

“…We investigate how risk of sexually acquiring or transmitting HIV in adolescent girls and young women (AGYW) changed following the real-world implementation of…”
Get full text

Analysis of Structure–Activity Relationships of Novel Inhibitors of the Macrophage Infectivity Potentiator (Mip) Proteins of Neisseria meningitidis, Neisseria gonorrhoeae, and Burkholderia pseudomallei by Scheuplein, Nicolas J., Bzdyl, Nicole M., Lohr, Theresa, Kibble, Emily A., Hasenkopf, Anja, Herbst, Carina, Sarkar-Tyson, Mitali, Holzgrabe, Ulrike

“…The macrophage infectivity potentiator (Mip) protein is a promising target for developing new drugs to combat antimicrobial resistance. New rapamycin-derived…”
Get full text

Isisekelo Sempilo study protocol for the effectiveness of HIV prevention embedded in sexual health with or without peer navigator support to reduce prevalence of transmissible HIV amongst adolescents and young adults in rural KwaZulu-Natal: a 2 x 2 factorial randomised controlled trial by Chidumwa, Glory, Chimbindi, Natsayi, Herbst, Carina, Okeselo, Nonhlanhla, Dreyer, Jaco, Zuma, Thembelihle, Smith, Theresa, Molina, Jean-Michel, Khoza, Thandeka, McGrath, Nuala, Seeley, Janet, Pillay, Deenan, Tanser, Frank, Harling, Guy, Sherr, Lorraine, Copas, Andrew, Baisley, Kathy, Shahmanesh, Maryam

“…Background Antiretroviral therapy (ART) through universal test and treat (UTT) and HIV pre-exposure prophylaxis (PrEP) substantially reduces HIV-related…”
Get full text

Thetha Nami ngithethe nawe , to reduce sexually transmissible HIV amongst young people in rural KwaZulu-Natal, South Africa by Busang, Jacob, Zuma, Thembelihle, Herbst, Carina, Okesola, Nonhlanhla, Chimbindi, Natsayi, Dreyer, Jaco, Mtshali, Nelisiwe, Smit, Theresa, Ngubane, Samkelisiwe, Hlongwane, Siphesihle, Gumede, Dumsani, Jalazi, Ashley, Mdluli, Simphiweyenkosi, Bird, Kristien, Msane, Sithembile, Danisa, Priscilla, Hanekom, Willem, Lebina, Limakatso, Behuhuma, Ngundu, Hendrickson, Cheryl, Miot, Jacqui, Seeley, Janet, Harling, Guy, Jarolimova, Jana, Sherr, Lorraine, Copas, Andrew, Baisley, Kathy, Shahmanesh, Maryam

“…Background Antiretroviral therapy (ART) through universal test and treat (UTT) and HIV pre-exposure prophylaxis (PrEP) substantially reduces HIV-related…”
Get full text

Cluster randomised controlled trial to determine the effect of peer delivery HIV self-testing to support linkage to HIV prevention among young women in rural KwaZulu-Natal, South Africa: a study protocol by Adeagbo, Oluwafemi Atanda, Mthiyane, Nondumiso, Herbst, Carina, Mee, Paul, Neuman, Melissa, Dreyer, Jaco, Chimbindi, Natsayi, Smit, Theresa, Okesola, Nonhlanhla, Johnson, Cheryl, Hatzold, Karin, Seeley, Janet, Cowan, Frances, Corbett, Liz, Shahmanesh, Maryam

“…IntroductionA cluster randomised controlled trial (cRCT) to determine whether HIV self-testing (HIVST) delivered by peers either directly or through…”
Get full text

Effectiveness of integrating HIV prevention within sexual reproductive health services with or without peer support among adolescents and young adults in rural KwaZulu-Natal, South Africa (Isisekelo Sempilo): 2 × 2 factorial, open-label, randomised controlled trial by Shahmanesh, Maryam, Chimbindi, Natsayi, Busang, Jacob, Chidumwa, Glory, Mthiyani, Nondumiso, Herbst, Carina, Okesola, Nonhlanhla, Dreyer, Jaco, Zuma, Thembelihle, Luthuli, Manono, Gumede, Dumsani, Hlongwane, Siphesihle, Mdluli, Simphiwe, Msane, Sithembile, Smit, Theresa, Molina, Jean-Michel, Khoza, Thandeka, Behuhuma, Ngundu Osee, McGrath, Nuala, Seeley, Janet, Harling, Guy, Sherr, Lorraine, Copas, Andrew, Baisley, Kathy

“…Approximately 200 000 South Africans acquired HIV in 2021 despite the availability of universal HIV test and treat and pre-exposure prophylaxis (PrEP). The aim…”
Get full text