Search Results - "Carias, Ann M"

Defining the Interaction of HIV-1 with the Mucosal Barriers of the Female Reproductive Tract by Carias, Ann M, McCoombe, Scott, McRaven, Michael, Anderson, Meegan, Galloway, Nicole, Vandergrift, Nathan, Fought, Angela J, Lurain, John, Duplantis, Maurice, Veazey, Ronald S, Hope, Thomas J

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Localization of infection in neonatal rhesus macaques after oral viral challenge by Taylor, Roslyn A, McRaven, Michael D, Carias, Ann M, Anderson, Meegan R, Matias, Edgar, Araínga, Mariluz, Allen, Edward J, Rogers, Kenneth A, Gupta, Sandeep, Kulkarni, Viraj, Lakhashe, Samir, Lorenzo-Redondo, Ramon, Thomas, Yanique, Strickland, Amanda, Villinger, Francois J, Ruprecht, Ruth M, Hope, Thomas J

“…Vertical transmission of human immunodeficiency virus (HIV) can occur in utero, during delivery, and through breastfeeding. We utilized Positron Emission…”
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PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure by Taylor, Roslyn A, Xiao, Sixia, Carias, Ann M, McRaven, Michael D, Thakkar, Divya N, Araínga, Mariluz, Allen, Edward J, Rogers, Kenneth A, Kumarapperuma, Sidath C, Gong, Siqi, Fought, Angela J, Anderson, Meegan R, Thomas, Yanique, Schneider, Jeffrey R, Goins, Beth, Fox, Peter, Villinger, Francois J, Ruprecht, Ruth M, Hope, Thomas J

“…Human immunodeficiency virus (HIV) vaccines have not been successful in clinical trials. Dimeric IgA (dIgA) in the form of secretory IgA is the most abundant…”
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Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies by Beddingfield, Brandon J., Maness, Nicholas J., Fears, Alyssa C., Rappaport, Jay, Aye, Pyone Pyone, Russell-Lodrigue, Kasi, Doyle-Meyers, Lara A., Blair, Robert V., Carias, Ann M., Madden, Patrick J., Redondo, Ramon Lorenzo, Gao, Hongmei, Montefiori, David, Hope, Thomas J., Roy, Chad J.

“…SARS-CoV-2 is a respiratory borne pathogenic beta coronavirus that is the source of a worldwide pandemic and the cause of multiple pathologies in man. The…”
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Expression Profile of Human Fc Receptors in Mucosal Tissue: Implications for Antibody-Dependent Cellular Effector Functions Targeting HIV-1 Transmission by Cheeseman, Hannah M, Carias, Ann M, Evans, Abbey B, Olejniczak, Natalia J, Ziprin, Paul, King, Deborah F L, Hope, Thomas J, Shattock, Robin J

“…The majority of new Human Immunodeficiency Virus (HIV)-1 infections are acquired via sexual transmission at mucosal surfaces. Partial efficacy (31.2%) of the…”
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Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract by Carias, Ann M, Allen, Shannon A, Fought, Angela J, Kotnik Halavaty, Katarina, Anderson, Meegan R, Jimenez, Maria L, McRaven, Michael D, Gioia, Casey J, Henning, Tara R, Kersh, Ellen N, Smith, James M, Pereira, Lara E, Butler, Katherine, McNicholl, S Janet M, Hendry, R Michael, Kiser, Patrick F, Veazey, Ronald S, Hope, Thomas J

“…Currently, there are mounting data suggesting that HIV-1 acquisition in women can be affected by the use of certain hormonal contraceptives. However, in…”
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Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques by Madden, Patrick J, Arif, Muhammad S, Becker, Mark E, McRaven, Michael D, Carias, Ann M, Lorenzo-Redondo, Ramon, Xiao, Sixia, Midkiff, Cecily C, Blair, Robert V, Potter, Elizabeth Lake, Martin-Sancho, Laura, Dodson, Alan, Martinelli, Elena, Todd, John-Paul M, Villinger, Francois J, Chanda, Sumit K, Aye, Pyone Pyone, Roy, Chad J, Roederer, Mario, Lewis, Mark G, Veazey, Ronald S, Hope, Thomas J

“…Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An…”
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Anatomic Distribution of Intravenously Injected IgG Takes Approximately 1 Week to Achieve Stratum Corneum Saturation in Vaginal Tissues by Carias, Ann M, Schneider, Jeffrey R, Madden, Patrick, Lorenzo-Redondo, Ramon, Araínga, Mariluz, Pegu, Amarendra, Cianci, Gianguido C, Maric, Danijela, Villinger, Francois, Mascola, John R, Veazey, Ronald S, Hope, Thomas J

“…i.v. injected Abs have demonstrated protection against simian HIV infection in rhesus macaques, paving the way for the Antibody Mediated Prevention trial in…”
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Quantitative Immunofluorescent Imaging of Immune Cells in Mucosal Tissues by Buchanan, Lane B, Shao, Zhongtian, Jiang, Yuan Chung, Lai, Abbie, Hope, Thomas J, Carias, Ann M, Prodger, Jessica L

“…Understanding the interplay between commensals, pathogens, and immune cells in the skin and mucosal tissues is critical to improve prevention and treatment of…”
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A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities by Schneider, Jeffrey R, Shen, Xiaoying, Orlandi, Chiara, Nyanhete, Tinashe, Sawant, Sheetal, Carias, Ann M, Smith, 4th, Archer D, Kelleher, Neil L, Veazey, Ronald S, Lewis, George K, Tomaras, Georgia D, Hope, Thomas J

“…We have recently shown that MUC16, a component of the glycocalyx of some mucosal barriers, has elevated binding to the G0 glycoform of the Fc portion of IgG…”
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Long-term direct visualization of passively transferred fluorophore-conjugated antibodies by Schneider, Jeffrey R., Carias, Ann M., Bastian, Arangaserry R., Cianci, Gianguido C., Kiser, Patrick F., Veazey, Ronald S., Hope, Thomas J.

“…The use of therapeutic antibodies, delivered by intravenous (IV) instillation, is a rapidly expanding area of biomedical treatment for a variety of conditions…”
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Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1 by Klein, Katja, Nankya, Immaculate, Nickel, Gabrielle, Ratcliff, Annette N, Meadows, Adam A J, Hathaway, Nicholas, Bailey, Jeffrey A, Stieh, Daniel J, Cheeseman, Hannah M, Carias, Ann M, Lobritz, Michael A, Mann, Jamie F S, Gao, Yong, Hope, Thomas J, Shattock, Robin J, Arts, Eric J

“…Exposure of the genital mucosa to a genetically diverse viral swarm from the donor HIV-1 can result in breakthrough and systemic infection by a single…”
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Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues by Allen, Shannon A, Carias, Ann M, Anderson, Meegan R, Okocha, Eneniziaogochukwu A, Benning, Lorie, McRaven, Michael D, Kelley, Z L, Lurain, John, Veazey, Ronald S, Hope, Thomas J

“…The majority of human immunodeficiency virus type 1 (HIV-1) transmission events occur in women when semen harboring infectious virus is deposited onto the…”
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Progesterone-based intrauterine device use is associated with a thinner apical layer of the human ectocervical epithelium and a lower ZO-1 mRNA expression by Tjernlund, Annelie, Carias, Ann M, Andersson, Sonia, Gustafsson-Sanchez, Susanna, Röhl, Maria, Petersson, Pernilla, Introini, Andrea, Hope, Thomas J, Broliden, Kristina

“…Currently, whether hormonal contraceptives affect male to female human immunodeficiency virus (HIV) transmission is being debated. In this study, we…”
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Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males by Gray, Clive M., O’Hagan, Kyle L., Lorenzo-Redondo, Ramon, Olivier, Abraham J., Amu, Sylvie, Chigorimbo-Murefu, Nyaradzo, Harryparsad, Rushil, Sebaa, Shorok, Maziya, Lungile, Dietrich, Janan, Otwombe, Kennedy, Martinson, Neil, Ferrian, Selena, Mkhize, Nonhlanhla N., Lewis, David A., Lang, Dirk, Carias, Ann M., Jaspan, Heather B., Wilson, Douglas P. K., McGilvray, Marcus, Cianci, Gianguido C., Anderson, Meegan R., Dinh, Minh H., Williamson, Anna-Lise, Passmore, Jo-Ann S., Chiodi, Francesca, Hope, Thomas J.

“…We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target…”
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Progesterone-Based Intrauterine Device Use Is Associated with a Thinner Apical Layer of the Human Ectocervical Epithelium and a Lower ZO-1 mRNA Expression1 by Tjernlund, Annelie, Carias, Ann M, Andersson, Sonia, Gustafsson-Sanchez, Susanna, Röhl, Maria, Petersson, Pernilla, Introini, Andrea, Hope, Thomas J, Broliden, Kristina

“…Currently, whether hormonal contraceptives affect male to female human immunodeficiency virus (HIV) transmission is being debated. In this study, we…”
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Phagocytosis: cell biology view of antiviral function by Carias, Ann M, Hope, Thomas J

“…PURPOSE OF REVIEWRecently, studies have suggested a role for Fc-mediated effector functions in viremic control of HIV infection and blocking HIV acquisition…”
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Anatomic distribution of intravenous injected IgG takes approximately 1 week to achieve stratum corneum saturation in vaginal tissues by Carias, Ann M., Schneider, Jeffrey R., Madden, Patrick, Lorenzo-Redondo, Ramon, Araínga, Mariluz, Pegu, Amarendra, Cianci, Gianguido C., Maric, Danijela, Villinger, Francois, Mascola, John R., Veazey, Ronald S., Hope, Thomas J.

“…IV-injected antibodies have demonstrated protection against SHIV infection in rhesus macaques paving the way for the AMP trial where at-risk individuals for…”
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Prevention of SHIV transmission by topical IFN-β treatment by Veazey, R S, Pilch-Cooper, H A, Hope, T J, Alter, G, Carias, A M, Sips, M, Wang, X, Rodriguez, B, Sieg, S F, Reich, A, Wilkinson, P, Cameron, M J, Lederman, M M

“…Understanding vaginal and rectal HIV transmission and protective cellular and molecular mechanisms is critical for designing new prevention strategies,…”
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