Search Results - "Carey, Seb J"

Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease by Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bamborough, Paul, Carey, Seb J, Johnson, Martin R, Jones, Paul S, Mills, Gail, Parry, Nigel R, Stewart, Alan J, Skarzynski, Tadeusz

“…In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors…”
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Pyrrolidine-5,5-trans-lactams. 1. Synthesis and Incorporation into Inhibitors of Hepatitis C Virus NS3/4A Protease by Andrews, David M, Carey, Seb J, Chaignot, Helene, Coomber, Barry A, Gray, Norman M, Hind, S. Lucy, Jones, Paul S, Mills, Gail, Robinson, J. Ed, Slater, Martin J

“…In this, the first of two letters, we outline the use of the pyrrolidine-5,5-trans-lactam template to design small, neutral, mechanism-based inhibitors of…”
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