Search Results - "Carey, F. A."

Interval cancers in a FOBT-based colorectal cancer population screening programme: implications for stage, gender and tumour site by Steele, R J C, McClements, P, Watling, C, Libby, G, Weller, D, Brewster, D H, Black, R, Carey, F A, Fraser, C G

“…Between 2000 and 2007, a demonstration pilot of biennial guaiac faecal occult blood test (GFOBT) screening was carried out in Scotland. Interval cancers were…”
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The colorectal adenoma-carcinoma sequence by Leslie, A., Carey, F. A., Pratt, N. R., Steele, R. J. C.

“…Background: It is widely accepted that the adenoma–carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence…”
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Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine by Smith, G, Bounds, R, Wolf, H, Steele, R J C, Carey, F A, Wolf, C R

“…Background: Response to EGFR -targeted therapies in colorectal cancer patients has been convincingly associated with Kirsten-Ras ( K-Ras ) mutation status…”
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The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma by Conlin, A, Smith, G, Carey, F A, Wolf, C R, Steele, R J C

“…Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to…”
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The impact of population-based faecal occult blood test screening on colorectal cancer mortality: a matched cohort study by Libby, G, Brewster, D H, McClements, P L, Carey, F A, Black, R J, Birrell, J, Fraser, C G, Steele, R J C

“…Background: Randomised trials show reduced colorectal cancer (CRC) mortality with faecal occult blood testing (FOBT). This outcome is now examined in a…”
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Results from the first three rounds of the Scottish demonstration pilot of FOBT screening for colorectal cancer by Steele, R J C, McClements, P L, Libby, G, Black, R, Morton, C, Birrell, J, Mowat, N A G, Wilson, J A, Kenicer, M, Carey, F A, Fraser, C G

“…To assess the effects of the first three rounds of a pilot colorectal screening programme based on guaiac faecal occult blood testing (gFOBT) and their…”
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Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours by Weidlich, S, Walsh, K, Crowther, D, Burczynski, M E, Feuerstein, G, Carey, F A, Steele, R J C, Wolf, C R, Miele, G, Smith, G

“…Background: The epidermal growth factor receptor-targeted monoclonal antibody cetuximab (Erbitux) was recently introduced for the treatment of metastatic…”
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Prognostic indicators for gastrointestinal stromal tumours: a clinicopathological and immunohistochemical study of 108 resected cases of the stomach by Wong, N A C S, Young, R, Malcomson, R D G, Nayar, A G, Jamieson, L A, Save, V E, Carey, F A, Brewster, D H, Han, C, Al-Nafussi, A

“…Aims:  Whether immunohistochemical markers increase accuracy in predicting prognosis for gastrointestinal stromal tumours (GISTs) remains uncertain. However,…”
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Automated immunochemical quantitation of haemoglobin in faeces collected on cards for screening for colorectal cancer by Fraser, C G, Mathew, C M, McKay, K, Carey, F A, Steele, R J C

“…Simple card collection systems are becoming available for faecal immunochemical tests (FITs) as well as guaiac faecal occult blood tests (gFOBTs). FITs are now…”
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Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas by Judson, H, Stewart, A, Leslie, A, Pratt, NR, Baty, DU, Steele, RJC, Carey, FA

“…Epigenetic mechanisms in carcinogenesis may have a significant role in the development of colorectal cancer. To investigate this phenomenon in early‐stage…”
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MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms by Amankwatia, E B, Chakravarty, P, Carey, F A, Weidlich, S, Steele, R J C, Munro, A J, Wolf, C R, Smith, G

“…Background: Colorectal cancers arise from benign adenomas, although not all adenomas progress to cancer and there are marked interpatient differences in…”
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Lower gastrointestinal symptoms are not predictive of colorectal neoplasia in a faecal occult blood screen-positive population by Ahmed, S., Leslie, A., Thaha, M. A., Carey, F. A., Steele, R. J. C.

“…Background: The aim of this study was to evaluate the incidence of lower gastrointestinal symptoms in faecal occult blood (FOB) test‐positive participants in a…”
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Scottish Bowel Screening Programme colonoscopy quality – scope for improvement? by Quyn, A. J., Fraser, C. G., Stanners, G., Carey, F. A., Rees, C. J., Moores, B., Steele, R. J.

“…Aim The delivery of the Scottish Bowel Screening Programme (SBoSP) is rooted in the provision of a high quality, effective and participant‐centred service…”
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Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma by Currie, G. P., Syme‐Grant, N. J., McFarlane, L. C., Carey, F. A., Lipworth, B. J.

“…Background: Noninvasive surrogate markers provide valuable information on the asthmatic inflammatory process. We wished to examine the effects of low dose…”
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Low faecal haemoglobin concentration potentially rules out significant colorectal disease by McDonald, P. J., Digby, J., Innes, C., Strachan, J. A., Carey, F. A., Steele, R. J. C., Fraser, C. G.

“…Aim The study aimed to determine whether faecal haemoglobin (Hb) concentration can assist in deciding who with lower abdominal symptoms will benefit from…”
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Effect of repeated invitations on uptake of colorectal cancer screening using faecal occult blood testing: analysis of prevalence and incidence screening by Steele, R J C, Kostourou, I, McClements, P, Watling, C, Libby, G, Weller, D, Brewster, D H, Black, R, Carey, F A, Fraser, C

“…Objective To analyse the effects of prevalence and incidence screening on uptake and detection of cancer in an ongoing, dynamic programme for colorectal…”
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Medications with anticoagulant properties increase the likelihood of a negative colonoscopy in faecal occult blood test population screening by Clarke, P., Jack, F., Carey, F. A., Steele, R. J. C.

“…Objective  The aim of this study was to evaluate the effect of medication with anticoagulant properties on the false positive rate in a population‐based faecal…”
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A survey of reporting of colorectal cancer in Scotland: compliance with guidelines and effect of proforma reporting by Woods, Y L, Mukhtar, S, McClements, P, Lang, J, Steele, R J, Carey, F A

“…The main purpose of the study was to present a baseline audit of reporting of colorectal cancers resection specimens in Scotland, audited against the Royal…”
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Patterns of uptake in a biennial faecal occult blood test screening programme for colorectal cancer by Steele, R. J. C., McClements, P. L., Libby, G., Carey, F. A., Fraser, C. G.

“…Aim The patterns of response in faecal occult blood test (FOBT) screening were studied. Method A total of 251 578 people invited three times for faecal occult…”
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Effect of gender, age and deprivation on key performance indicators in a FOBT-based colorectal screening programme by Steele, R J C, Kostourou, I, McClements, P, Watling, C, Libby, G, Weller, D, Brewster, D H, Black, R, Carey, F A, Fraser, C

“…To assess the effect of gender, age and deprivation on key performance indicators in a colorectal cancer screening programme. Between March 2000 and May 2006 a…”
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