Search Results - "Carew, Thomas J."

Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins by Ye, Xiaojing, Carew, Thomas J.

“…Small G proteins are an extensive family of proteins that bind and hydrolyze GTP. They are ubiquitous inside cells, regulating a wide range of cellular…”
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Distinct Growth Factor Families Are Recruited in Unique Spatiotemporal Domains during Long-Term Memory Formation in Aplysia californica by Kopec, Ashley M., Philips, Gary T., Carew, Thomas J.

“…Several growth factors (GFs) have been implicated in long-term memory (LTM), but no single GF can support all of the plastic changes that occur during memory…”
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Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance by Philips, Gary T., Kopec, Ashley M., Carew, Thomas J.

“…•The spacing effect is a highly conserved feature of memory formation from humans to invertebrates.•Recent molecular studies provide new insights into how…”
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Transsynaptic Coordination of Presynaptic and Postsynaptic Modifications underlying Enduring Synaptic Plasticity by Ye, Xiaojing, Carew, Thomas J.

“…Neurexins and neuroligins are cell adhesion molecules that form transsynaptic interactions. In this issue of Neuron, Choi et al. report that…”
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Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia by Ye, Xiaojing, Marina, Andreea, Carew, Thomas J

“…It is widely appreciated that memory processing engages a wide range of molecular signaling cascades in neurons, but how these cascades are temporally and…”
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The Journal of Neuroscience's 40th Anniversary: Looking Back, Looking Forward by Carew, Thomas J

“…Some of us fortunate enough to have published a paper in The Journal of Neuroscience in its inaugural year (1981) have been asked to write a Progressions…”
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A Novel Cysteine-Rich Neurotrophic Factor in "Aplysia" Facilitates Growth, MAPK Activation, and Long-Term Synaptic Facilitation by Pu, Lu, Kopec, Ashley M, Boyle, Heather D, Carew, Thomas J

“…Neurotrophins are critically involved in developmental processes such as neuronal cell survival, growth, and differentiation, as well as in adult synaptic…”
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The Neurohumanities: An Emerging Partnership for Exploring the Human Experience by Carew, Thomas J., Ramaswami, Mani

“…Neuroscience has an extraordinary opportunity to investigate issues historically addressed by the arts, humanities, and social sciences. As a guide, we suggest…”
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Precise timing of ERK phosphorylation/dephosphorylation determines the outcome of trial repetition during long-term memory formation by Kukushkin, Nikolay V, Tabassum, Tasnim, Carew, Thomas J

“…Two-trial learning in reveals nonlinear interactions between training trials: A single trial has no effect, but two precisely spaced trials induce long-term…”
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Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia by Ye, Xiaojing, Shobe, Justin L, Sharma, Shiv K, Marina, Andreea, Carew, Thomas J

“…Memory formation is highly sensitive to specific patterns of training, but the cellular and molecular mechanisms underlying pattern sensitivity are not well…”
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Postsynaptic Effects of "Aplysia" Cysteine-Rich Neurotrophic Factor in the Induction of Activity-Dependent Long-Term Facilitation in "Aplysia Californica" by Alexandrescu, Anamaria, Carew, Thomas J

“…The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory…”
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Pattern detection in the TGFβ cascade controls the induction of long-term synaptic plasticity by Miranda, Paige, Mirisis, Anastasios A, Kukushkin, Nikolay V, Carew, Thomas J

“…Transforming growth factor β (TGFβ) is required for long-term memory (LTM) for sensitization in . When LTM is induced using a two-trial training protocol, TGFβ…”
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The ELAV family of RNA-binding proteins in synaptic plasticity and long-term memory by Mirisis, Anastasios A., Carew, Thomas J.

“…•Specific RNA-binding proteins bind mRNA elements and promote stabilization.•ELAV proteins promote stabilization, transcript shuttling, and translation.•The…”
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A Tropomyosin-Related Kinase B Ligand Is Required for ERK Activation, Long-Term Synaptic Facilitation, and Long-Term Memory in Aplysia by Sharma, Shiv K., Sherff, Carolyn M., Stough, Shara, Hsuan, Vickie, Carew, Thomas J.

“…BDNF, which acts through tropomyosin-related kinase B (TrkB) receptors during mammalian development, also enhances longterm synaptic facilitation (LTF) in…”
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Serotonergic Modulation in Aplysia. I. Distributed Serotonergic Network Persistently Activated by Sensitizing Stimuli by Marinesco, Stephane, Kolkman, Kristine E, Carew, Thomas J

“…Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine California 92697-4550 Submitted 3…”
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ELAV Proteins Bind and Stabilize C/EBP mRNA in the Induction of Long-Term Memory in Aplysia by Mirisis, Anastasios A, Kopec, Ashley M, Carew, Thomas J

“…Long-term memory (LTM) formation is a critical survival process by which an animal retains information about prior experiences to guide future behavior. In the…”
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The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity by Mirisis, Anastasios A, Alexandrescu, Anamaria, Carew, Thomas J, Kopec, Ashley M

“…The ability to form long-lasting memories is critical to survival and thus is highly conserved across the animal kingdom. By virtue of its complexity, this…”
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Neuroscience and education: an ideal partnership for producing evidence-based solutions to Guide 21(st) Century Learning by Carew, Thomas J, Magsamen, Susan H

“…Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a…”
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MAPK establishes a molecular context that defines effective training patterns for long-term memory formation by Philips, Gary T, Ye, Xiaojing, Kopec, Ashley M, Carew, Thomas J

“…Although the importance of spaced training trials in the formation of long-term memory (LTM) is widely appreciated, surprisingly little is known about the…”
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Interaction between amount and pattern of training in the induction of intermediate- and long-term memory for sensitization in aplysia by Sutton, Michael A, Ide, Jasmine, Masters, Sarah E, Carew, Thomas J

“…In Aplysia, three distinct phases of memory for sensitization can be dissociated based on their temporal and molecular features. A single training trial…”
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