Search Results - "Carels, Carine E."

Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts by Conte, Federica, Oti, Martin, Dixon, Jill, Carels, Carine E. L., Rubini, Michele, Zhou, Huiqing

“…Orofacial clefts (OFCs) represent a large fraction of human birth defects and are one of the most common phenotypes affected by large copy number variants…”
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Targeting the redox balance in inflammatory skin conditions by Wagener, Frank A D T G, Carels, Carine E, Lundvig, Ditte M S

“…Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal physiological conditions, ROS production is tightly regulated, and ROS…”
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Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae by Gebuijs, Liesbeth, Wagener, Frank A, Zethof, Jan, Carels, Carine E, Von den Hoff, Johannes W, Metz, Juriaan R

“…A key pathway controlling skeletal development is fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling. Major regulatory functions of FGF signaling…”
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Deletions and loss-of-function variants in TP63 associated with orofacial clefting by Khandelwal, Kriti D, van den Boogaard, Marie-José H, Mehrem, Sarah L, Gebel, Jakob, Fagerberg, Christina, van Beusekom, Ellen, van Binsbergen, Ellen, Topaloglu, Ozan, Steehouwer, Marloes, Gilissen, Christian, Ishorst, Nina, van Rooij, Iris A L M, Roeleveld, Nel, Christensen, Kaare, Schoenaers, Joseph, Bergé, Stefaan, Murray, Jeffrey C, Hens, Greet, Devriendt, Koen, Ludwig, Kerstin U, Mangold, Elisabeth, Hoischen, Alexander, Zhou, Huiqing, Dötsch, Volker, Carels, Carine E L, van Bokhoven, Hans

“…We aimed to identify novel deletions and variants of TP63 associated with orofacial clefting (OFC). Copy number variants were assessed in three OFC families…”
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Three-dimensional imaging methods for quantitative analysis of facial soft tissues and skeletal morphology in patients with orofacial clefts: a systematic review by Kuijpers, Mette A R, Chiu, Yu-Ting, Nada, Rania M, Carels, Carine E L, Fudalej, Piotr S

“…Current guidelines for evaluating cleft palate treatments are mostly based on two-dimensional (2D) evaluation, but three-dimensional (3D) imaging methods to…”
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Vitamin A and clefting: putative biological mechanisms by Ackermans, Mignon MG, Zhou, Huiqing, Carels, Carine EL, Wagener, Frank ADTG, Von den Hoff, Johannes W

“…Nutritional factors such as vitamin intake contribute to the etiology of cleft palate. Vitamin A is a regulator of embryonic development. Excess vitamin A can…”
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Further delineation of the KBG syndrome phenotype caused by ANKRD11 aberrations by Ockeloen, Charlotte W, Willemsen, Marjolein H, de Munnik, Sonja, van Bon, Bregje W M, de Leeuw, Nicole, Verrips, Aad, Kant, Sarina G, Jones, Elizabeth A, Brunner, Han G, van Loon, Rosa L E, Smeets, Eric E J, van Haelst, Mieke M, van Haaften, Gijs, Nordgren, Ann, Malmgren, Helena, Grigelioniene, Giedre, Vermeer, Sascha, Louro, Pedro, Ramos, Lina, Maal, Thomas J J, van Heumen, Celeste C, Yntema, Helger G, Carels, Carine E L, Kleefstra, Tjitske

“…Loss-of-function variants in ANKRD11 were identified as the cause of KBG syndrome, an autosomal dominant syndrome with specific dental, neurobehavioural,…”
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Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells by Cremers, Niels A J, Lundvig, Ditte M S, van Dalen, Stephanie C M, Schelbergen, Rik F, van Lent, Peter L E M, Szarek, Walter A, Regan, Raymond F, Carels, Carine E, Wagener, Frank A D T G

“…Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered…”
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Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate by Mammadova, Aysel, Zhou, Huiqing, Carels, Carine E.L., Von den Hoff, Johannes W.

“…Retinoic acid (RA), the active derivative of vitamin A, is one of the major regulators of embryonic development, including the development of the epidermis,…”
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MicroRNAs in Palatogenesis and Cleft Palate by Schoen, Christian, Aschrafi, Armaz, Thonissen, Michelle, Poelmans, Geert, Von den Hoff, Johannes W, Carels, Carine E L

“…Palatogenesis requires a precise spatiotemporal regulation of gene expression, which is controlled by an intricate network of transcription factors and their…”
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Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts by Vogelaar, Ingrid P, Figueiredo, Joana, van Rooij, Iris A L M, Simões-Correia, Joana, van der Post, Rachel S, Melo, Soraia, Seruca, Raquel, Carels, Carine E L, Ligtenberg, Marjolijn J L, Hoogerbrugge, Nicoline

“…Orofacial clefts (OFC) are among the most common birth defects worldwide. The etiology of non-syndromic OFC is still largely unknown. During embryonic…”
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Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair by Cremers, Niels A J, Wever, Kimberley E, Wong, Ronald J, van Rheden, René E M, Vermeij, Eline A, van Dam, Gooitzen M, Carels, Carine E, Lundvig, Ditte M S, Wagener, Frank A D T G

“…Skin wounds may lead to scar formation and impaired functionality. Remote ischemic preconditioning (RIPC) can induce the anti-inflammatory enzyme heme…”
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Delayed cutaneous wound closure in HO‐2 deficient mice despite normal HO‐1 expression by Lundvig, Ditte M. S., Scharstuhl, Alwin, Cremers, Niels A. J., Pennings, Sebastiaan W. C., Paske, Jeroen, Rheden, René, Run‐van Breda, Coby, Regan, Raymond F., Russel, Frans G. M., Carels, Carine E., Maltha, Jaap C., Wagener, Frank A. D. T. G.

“…Impaired wound healing can lead to scarring, and aesthetical and functional problems. The cytoprotective haem oxygenase (HO) enzymes degrade haem into iron,…”
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Genomic approaches for studying craniofacial disorders by Khandelwal, Kriti D., van Bokhoven, Hans, Roscioli, Tony, Carels, Carine E.L., Zhou, Huiqing

“…Fast developing technologies in genomics have driven genetic studies of human diseases from classical candidate approaches toward hypothesis‐free and…”
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Retinoic acid effects on in vitro palatal fusion and WNT signaling by Roa Fuentes, Laury Amelia, Bloemen, Marjon, Carels, Carine EL, Wagener, Frank ADTG, Von den Hoff, Johannes W

“…Retinoic acid is the main active vitamin A derivate and a key regulator of embryonic development. Excess of retinoic acid can disturb palate development in…”
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Deregulated Adhesion Program in Palatal Keratinocytes of Orofacial Cleft Patients by Mammadova, Aysel, Carels, Carine E L, Zhou, Jie, Gilissen, Christian, Helmich, Maria P A C, Bian, Zhuan, Zhou, Huiqing, Von den Hoff, Johannes W

“…Orofacial clefts (OFCs) are the most frequent craniofacial birth defects. An orofacial cleft (OFC) occurs as a result of deviations in palatogenesis. Cell…”
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Tooth agenesis patterns in bilateral cleft lip and palate by Bartzela, Theodosia N., Carels, Carine E.L., Bronkhorst, Ewald M., Rønning, Elisabeth, Rizell, Sara, Kuijpers-Jagtman, Anne Marie

“…Bartzela TN, Carels CEL, Bronkhorst EM, Rønning E, Rizell S, Kuijpers‐Jagtman AM. Tooth agenesis patterns in bilateral cleft lip and palate. Eur J Oral Sci…”
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MSX1 mutations and associated disease phenotypes: genotype-phenotype relations by Liang, Jia, Von den Hoff, Johannes, Lange, Joanna, Ren, Yijin, Bian, Zhuan, Carels, Carine E L

“…The Msx1 transcription factor is involved in multiple epithelial-mesenchymal interactions during vertebrate embryogenesis. It has pleiotropic effects in…”
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Retinoic acid disrupts osteogenesis in pre-osteoblasts by down-regulating WNT signaling by Roa, Laury A., Bloemen, Marjon, Carels, Carine E.L., Wagener, Frank A.D.T.G., Von den Hoff, Johannes W.

“…•RA inhibits differentiation and mineralization of MC-3T3 pre-osteoblasts.•RA increases the expression of the osteogenic lineage factor RunX2.•RA decreases the…”
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A potential osteogenic role for microRNA-181a-5p during palatogenesis by Schoen, Christian, Bloemen, Marjon, Carels, Carine E L, Verhaegh, Gerald W, Van Rheden, Rene, Roa, Laury A, Glennon, Jeffrey C, Von den Hoff, Johannes W

“…Summary Background In a previous study, we found that the highly conserved hsa-miR-181a-5p is downregulated in palatal fibroblasts of non-syndromic cleft…”
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