Search Results - "Cardoso, Sandra"

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization by Finley, Lydia W.S., Carracedo, Arkaitz, Lee, Jaewon, Souza, Amanda, Egia, Ainara, Zhang, Jiangwen, Teruya-Feldstein, Julie, Moreira, Paula I., Cardoso, Sandra M., Clish, Clary B., Pandolfi, Pier Paolo, Haigis, Marcia C.

“…Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg…”
Get full text

The neuromicrobiology of Parkinson’s disease: A unifying theory by Munoz-Pinto, Mario F., Empadinhas, Nuno, Cardoso, Sandra M.

“…•Parkinson’s disease (PD) is a common progressive neurodegenerative disease with many potential aetiologies.•Bacteria are the new players involved in PD onset…”
Get full text

The Microbiome-Mitochondria Dance in Prodromal Parkinson's Disease by Cardoso, Sandra M, Empadinhas, Nuno

“…The brain is an immunologically active organ where neurons and glia cells orchestrate complex innate immune responses against infections and injuries. Neuronal…”
Get full text

Bone Disease in HIV Infection: A Practical Review and Recommendations for HIV Care Providers by McComsey, Grace A., Tebas, Pablo, Shane, Elizabeth, Yin, Michael T., Overton, E. Turner, Huang, Jeannie S., Aldrovandi, Grace M., Cardoso, Sandra W., Santana, Jorge L., Brown, Todd T.

“…Low bone mineral density (BMD) is prevalent in human immunodeficiency virus (HIV)-infected subjects. Initiation of antiretroviral therapy is associated with a…”
Get full text

The mitochondrial cascade hypothesis for Parkinson's disease by Cardoso, Sandra M

“…During the past decades, we have witnessed significant advances in our understanding of the molecular etiology of Parkinson's disease (PD). The unearthing of…”
Get more information

Obesity following ART initiation is common and influenced by both traditional and HIV-/ART-specific risk factors by Bakal, David R, Coelho, Lara E, Luz, Paula M, Clark, Jesse L, De Boni, Raquel B, Cardoso, Sandra W, Veloso, Valdilea G, Lake, Jordan E, Grinsztejn, Beatriz

“…Obesity rates are increasing among HIV-infected individuals, but risk factors for obesity development on ART remain unclear. In a cohort of HIV-infected adults…”
Get full text

LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis by Esteves, A. Raquel, Swerdlow, Russell H., Cardoso, Sandra M.

“…Leucine-rich repeat kinase 2 (LRRK2) is a large, ubiquitous protein of unknown function. Mutations in the gene encoding LRRK2 have been linked to familial and…”
Get full text

Reduction of class I histone deacetylases ameliorates ER‐mitochondria cross‐talk in Alzheimer's disease by Marinho, Daniela, Ferreira, Ildete Luísa, Lorenzoni, Ricardo, Cardoso, Sandra M., Santana, Isabel, Rego, A. Cristina

“…Several molecular mechanisms have been described in Alzheimer's disease (AD), including repressed gene transcription and mitochondrial and endoplasmic…”
Get full text

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease by Rajeshwari, Rajeshwari, Chand, Karam, Candeias, Emanuel, Cardoso, Sandra M, Chaves, Sílvia, Santos, M Amélia

“…Research on neurodegenerative brain disorders, namely the age-dependent Alzheimer's disease (AD), has been intensified in the last decade due to the absence of…”
Get full text

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons by Silva, Diana F., Candeias, Emanuel, Esteves, A. Raquel, Magalhães, João D., Ferreira, I. Luísa, Nunes-Costa, Daniela, Rego, A. Cristina, Empadinhas, Nuno, Cardoso, Sandra M.

“…Abstract Background After decades of research recognizing it as a complex multifactorial disorder, sporadic Alzheimer’s disease (sAD) still has no known…”
Get full text

Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis by Servaas, Nila H., Hiddingh, Sanne, Chouri, Eleni, Wichers, Catharina G. K., Affandi, Alsya J., Ottria, Andrea, Bekker, Cornelis P. J., Cossu, Marta, Silva‐Cardoso, Sandra C., Kroef, Maarten, Hinrichs, Anneline C., Carvalheiro, Tiago, Vazirpanah, Nadia, Beretta, Lorenzo, Rossato, Marzia, Bonte‐Mineur, Femke, Radstake, Timothy R. D. J., Kuiper, Jonas J. W., Boes, Marianne, Pandit, Aridaman

“…Objective This study was undertaken to identify key disease pathways driving conventional dendritic cell (cDC) alterations in systemic sclerosis (SSc). Methods…”
Get full text

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease by Hiremathad, Asha, Keri, Rangappa S., Esteves, A. Raquel, Cardoso, Sandra M., Chaves, Sílvia, Santos, M. Amélia

“…Alzheimer's disease (AD) is a severe age-dependent neurodegenerative disorder affecting millions of people, with no cure so far. The current treatments only…”
Get full text

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease by Fancellu, Gaia, Chand, Karam, Tomás, Daniel, Orlandini, Elisabetta, Piemontese, Luca, Silva, Diana F., Cardoso, Sandra M., Chaves, Sílvia, Santos, M. Amélia

“…Pursuing the widespread interest on multi-target drugs to combat Alzheimer´s disease (AD), a new series of hybrids was designed and developed based on the…”
Get full text

CXCL4 is a novel inducer of human Th17 cells and correlates with IL‐17 and IL‐22 in psoriatic arthritis by Affandi, Alsya J., Silva‐Cardoso, Sandra C., Garcia, Samuel, Leijten, Emmerik F. A., Kempen, Tessa S., Marut, Wioleta, Roon, Joel A. G., Radstake, Timothy R. D. J.

“…CXCL4 regulates multiple facets of the immune response and is highly upregulated in various Th17‐associated rheumatic diseases. However, whether CXCL4 plays a…”
Get full text

Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome by Kroef, Maarten, Hoogen, Lucas L., Mertens, Jorre S., Blokland, Sofie L.M., Haskett, Scott, Devaprasad, Abhinandan, Carvalheiro, Tiago, Chouri, Eleni, Vazirpanah, Nadia, Cossu, Marta, Wichers, Catherina G.K, Silva‐Cardoso, Sandra C., Affandi, Alsya J., Bekker, Cornelis P.J., Lopes, Ana P., Hillen, Maarten R., Bonte‐Mineur, Femke, Kok, Marc R., Beretta, Lorenzo, Rossato, Marzia, Mingueneau, Michaël, Roon, Joel A.G., Radstake, Timothy R.D.J

“…Systemic sclerosis (SSc), systemic lupus erythematosus (SLE) and primary Sjögrens syndrome (pSS) are clinically distinct systemic autoimmune diseases (SADs)…”
Get full text

The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson’s Disease by Santos, Daniel, Esteves, A. Raquel, Silva, Diana F., Januário, Cristina, Cardoso, Sandra M.

“…Accumulating data suggests that mitochondrial deficits may underline both sporadic and familial Parkinson’s disease (PD) neurodegenerative process. Impairment…”
Get full text

CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells by Silva‐Cardoso, Sandra C., Tao, Weiyang, Fernández, Beatriz Malvar, Boes, Marianne, Radstake, Timothy R.D.J., Pandit, Aridaman

“…RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that…”
Get full text

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates by Piemontese, Luca, Tomás, Daniel, Hiremathad, Asha, Capriati, Vito, Candeias, Emanuel, Cardoso, Sandra M., Chaves, Sílvia, Santos, M. Amélia

“…A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer's…”
Get full text

Is Alzheimer's disease an inflammasomopathy? by Pereira, Claudia F, Santos, Armanda E, Moreira, Paula I, Pereira, Ana Catarina, Sousa, Fabio J, Cardoso, Sandra M, Cruz, M Teresa

“…Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there…”
Get full text

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson’s Disease by Esteves, A. Raquel, Cardoso, Sandra M.

“…Mutations in leucine-rich repeat kinase 2 (lrrk2) gene cause inherited Parkinson’s disease (PD), and common variants in lrrk2 are a risk factor for sporadic…”
Get full text