Search Results - "Cardoso, João C. R."

Specific Evolution and Gene Family Expansion of Complement 3 and Regulatory Factor H in Fish by Najafpour, Babak, Cardoso, João C R, Canário, Adelino V M, Power, Deborah M

“…The complement system comprises a large family of plasma proteins that play a central role in innate and adaptive immunity. To better understand the evolution…”
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Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doublings by Cardoso, João C. R., Bergqvist, Christina A., Larhammar, Dan

“…The ancestor of gnathostomes (jawed vertebrates) is generally considered to have undergone two rounds of whole genome duplication (WGD). The timing of these…”
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Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) by Cardoso, João C. R., Garcia, Manuel G., Power, Deborah M.

“…Pituitary Adenylate Cyclase activating Peptide (PACAP) is a well-conserved neuropeptide characteristic of vertebrates. This pluripotent hypothalamic…”
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Domain-Dependent Evolution Explains Functional Homology of Protostome and Deuterostome Complement C3-Like Proteins by Peng, Maoxiao, Li, Zhi, Cardoso, João C R, Niu, Donghong, Liu, Xiaojun, Dong, Zhiguo, Li, Jiale, Power, Deborah M

“…Complement proteins emerged early in evolution but outside the vertebrate clade they are poorly characterized. An evolutionary model of C3 family members…”
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Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages by Cardoso, João C R, Bergqvist, Christina A, Félix, Rute C, Larhammar, Dan

“…The evolution of the peptide family consisting of corticotropin-releasing hormone (CRH) and the three urocortins (UCN1-3) has been puzzling due to uneven…”
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Nematode and arthropod genomes provide new insights into the evolution of class 2 B1 GPCRs by Cardoso, João C R, Félix, Rute C, Power, Deborah M

“…Nematodes and arthropods are the most speciose animal groups and possess Class 2 B1 G-protein coupled receptors (GPCRs). Existing models of invertebrate Class…”
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Evolution and Potential Function in Molluscs of Neuropeptide and Receptor Homologues of the Insect Allatostatins by Li, Zhi, Cardoso, João C R, Peng, Maoxiao, Inácio, João P S, Power, Deborah M

“…The allatostatins (ASTs), AST-A, AST-B and AST-C, have mainly been investigated in insects. They are a large group of small pleotropic alloregulatory…”
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Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken by Pinheiro, Pedro L C, Cardoso, João C R, Power, Deborah M, Canário, Adelino V M

“…The parathyroid hormone (PTH)-family consists of a group of structurally related factors that regulate calcium and bone homeostasis and are also involved in…”
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PACAP/GCGa Is an Important Modulator of the Amphioxus CNS-Hatschek's Pit Axis, the Homolog of the Vertebrate Hypothalamic-Pituitary Axis in the Basal Chordates by On, Jason S W, Su, Liuru, Shen, Hong, Arokiaraj, Aloysius W R, Cardoso, João C R, Li, Guang, Chow, Billy K C

“…The Hatschek's pit in the cephalochordate amphioxus, an invertebrate deuterostome basal to chordates is suggested to be the functional homolog structure of the…”
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Conserved domains and evolution of secreted phospholipases A2 by Nevalainen, Timo J., Cardoso, João C. R., Riikonen, Pentti T.

“…Secreted phospholipases A2 (sPLA2s) are lipolytic enzymes present in organisms ranging from prokaryotes to eukaryotes but their origin and emergence are poorly…”
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Persistence of the ABCC6 genes and the emergence of the bony skeleton in vertebrates by Parreira, Bruna, Cardoso, João C. R., Costa, Rita, Couto, Ana Rita, Bruges-Armas, Jácome, Power, Deborah M.

“…The ATP-binding cassette transporter 6 ( ABCC6 ) gene encodes a cellular transmembrane protein transporter (MRP6) that is involved in the regulation of tissue…”
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Cartilage acidic protein 1, a new member of the beta‐propeller protein family with amyloid propensity by Anjos, Liliana, Morgado, Isabel, Guerreiro, Marta, Cardoso, João C. R., Melo, Eduardo P., Power, Deborah M.

“…ABSTRACT Cartilage acidic protein1 (CRTAC1) is an extracellular matrix protein of chondrogenic tissue in humans and its presence in bacteria indicate it is of…”
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The serendipitous origin of chordate secretin peptide family members by Cardoso, João C R, Vieira, Florbela A, Gomes, Ana S, Power, Deborah M

“…The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have…”
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Evolution of secretin family GPCR members in the metazoa by Cardoso, João C R, Pinto, Vanda C, Vieira, Florbela A, Clark, Melody S, Power, Deborah M

“…Comparative approaches using protostome and deuterostome data have greatly contributed to understanding gene function and organismal complexity. The family 2…”
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Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken by Pinheiro, Pedro L C, Cardoso, João C R, Gomes, Ana S, Fuentes, Juan, Power, Deborah M, Canário, Adelino V M

“…Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) belong to a family of endocrine factors that share a highly conserved N-terminal region (amino acids…”
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Evolution and diversity of alpha-carbonic anhydrases in the mantle of the Mediterranean mussel (Mytilus galloprovincialis) by Cardoso, João C. R., Ferreira, Vinicius, Zhang, Xushuai, Anjos, Liliana, Félix, Rute C., Batista, Frederico M., Power, Deborah M.

“…The α-carbonic anhydrases (α-CAs) are a large and ancient group of metazoan-specific enzymes. They generate bicarbonate from metabolic carbon dioxide and…”
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A new subfamily of ionotropic glutamate receptors unique to the echinoderms with putative sensory role by Sania, Rubaiyat E., Cardoso, João C. R., Louro, Bruno, Marquet, Nathalie, Canário, Adelino V. M.

“…Chemosensation is a critical signalling process in animals and especially important in sea cucumbers, a group of ecologically and economically important marine…”
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Fish lysozyme gene family evolution and divergent function in early development by Li, Lisen, Cardoso, João C.R., Félix, Rute C., Mateus, Ana Patrícia, Canário, Adelino V.M., Power, Deborah M.

“…Lysozymes are an ancient group of antimicrobial enzymes of the innate immune system. Here we provide a comparative analysis of the evolution and function of…”
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Thyroid hormone receptor: A new player in epinephrine-induced larval metamorphosis of the hard-shelled mussel by Li, Yi-Feng, Cheng, Yu-Lan, Chen, Ke, Cheng, Zhi-Yang, Zhu, Xin, C. R. Cardoso, João, Liang, Xiao, Zhu, You-Ting, Power, Deborah M., Yang, Jin-Long

“…•A homologue of the vertebrate thyroid receptors (TRs) was identified in the hard-shelled mussel.•Knock-down of the mussel TR gene in pediveliger larvae…”
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The calcitonin-like system is an ancient regulatory system of biomineralization by Cardoso, João C. R., Félix, Rute C., Ferreira, Vinícius, Peng, MaoXiao, Zhang, Xushuai, Power, Deborah M.

“…Biomineralization is the process by which living organisms acquired the capacity to accumulate minerals in tissues. Shells are the biomineralized exoskeleton…”
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