Search Results - "Cardoso, Evelina"
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Therapeutic Drug Monitoring of Targeted Anticancer Protein Kinase Inhibitors in Routine Clinical Use: A Critical Review
Published in Therapeutic drug monitoring (01-02-2020)“…Therapeutic response to oral targeted anticancer protein kinase inhibitors (PKIs) varies widely between patients, with insufficient efficacy of some of them…”
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Quantification of the next-generation oral anti-tumor drugs dabrafenib, trametinib, vemurafenib, cobimetinib, pazopanib, regorafenib and two metabolites in human plasma by liquid chromatography-tandem mass spectrometry
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15-04-2018)“…A sensitive and selective method of high performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (MS/MS) has been developed for the…”
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Interventions to support adherence to oral anticancer therapies: research challenges, lessons learned, and strategies to overcome them from Australia and Switzerland
Published in Supportive care in cancer (01-05-2022)“…Not monitoring adherence to oral anticancer therapies (OAT) can lead to poor clinical outcomes, including premature death as reported by Foulon et al. (Acta…”
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Population Pharmacokinetics of Erlotinib in Patients With Non–small Cell Lung Cancer: Its Application for Individualized Dosing Regimens in Older Patients
Published in Clinical therapeutics (01-07-2020)“…Erlotinib is an oral first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor approved for non–small cell lung cancers (NSCLC) with…”
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Exposure-Response Analysis of Osimertinib in Patients with Advanced Non-Small-Cell Lung Cancer
Published in Pharmaceutics (01-09-2022)“…High interindividual variability (IIV) of the clinical response to epidermal growth factor receptor (EGFR) inhibitors such as osimertinib in non-small-cell…”
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Infant exposure to Fluvoxamine through placenta and human milk: a case series - A contribution from the ConcePTION project
Published in Frontiers in psychiatry (18-05-2023)“…Fluvoxamine is widely used to treat depression during pregnancy and lactation. However, limited data are available on its transfer to the fetus or in human…”
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Population Pharmacokinetics of Palbociclib and Its Correlation with Clinical Efficacy and Safety in Patients with Advanced Breast Cancer
Published in Pharmaceutics (21-06-2022)“…Neutropenia is the most frequent dose-limiting toxicity reported in patients with metastatic breast cancer receiving palbociclib. The objective of this study…”
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Optimizing Oral Targeted Anticancer Therapies Study for Patients With Solid Cancer: Protocol for a Randomized Controlled Medication Adherence Program Along With Systematic Collection and Modeling of Pharmacokinetic and Pharmacodynamic Data
Published in JMIR research protocols (29-06-2021)“…BackgroundThe strengthening or substitution of intravenous cytotoxic chemotherapy cycles by oral targeted anticancer therapies, such as protein kinase…”
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Effect of Adherence on Pharmacokinetic/Pharmacodynamic Relationships of Oral Targeted Anticancer Drugs
Published in Clinical pharmacokinetics (2018)“…The emergence of oral targeted anticancer agents transformed several cancers into chronic conditions with a need for long-term oral treatment. Although cancer…”
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Safety of medicines during breastfeeding - from case report to modeling: a contribution from the ConcePTION project
Published in Expert opinion on drug metabolism & toxicology (04-05-2023)“…Despite many research efforts, current data on the safety of medicines during breastfeeding are either fragmented or lacking, resulting in restrictive labeling…”
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A pharmacist-led interprofessional medication adherence program improved adherence to oral anticancer therapies: The OpTAT randomized controlled trial
Published in PloS one (07-06-2024)“…Oral anticancer therapies such as protein kinase inhibitors (PKIs) are increasingly prescribed in cancer care. We aimed to evaluate the impact of a…”
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Population Pharmacokinetics of Trametinib and Impact of Nonadherence on Drug Exposure in Oncology Patients as Part of the Optimizing Oral Targeted Anticancer Therapies Study
Published in Cancers (11-06-2024)“…Trametinib is a targeted therapy used for the treatment of solid tumours, with significant variability reported in real-life studies. This variability…”
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A population pharmacokinetic model for sertraline in women during the perinatal period—A contribution from the ConcePTION project
Published in British journal of clinical pharmacology (01-11-2024)“…Aims Sertraline is frequently prescribed for mental health conditions in both pregnant and breastfeeding women. According to the limited available data, only…”
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Maternal drugs and breastfeeding: Risk assessment from pharmacokinetics to safety evidence - A contribution from the ConcePTION project
Published in Therapie (01-03-2023)“…Human milk is the most appropriate form of nutrition for infants while taking medication during the postpartum period is common. Discontinuation of…”
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Therapeutic drug monitoring of targeted anticancer therapy
Published in Biomarkers in medicine (01-09-2015)“…New oral targeted anticancer therapies are revolutionizing cancer treatment by transforming previously deadly malignancies into chronically manageable…”
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Adherence to the CDK 4/6 Inhibitor Palbociclib and Omission of Dose Management Supported by Pharmacometric Modelling as Part of the OpTAT Study
Published in Cancers (01-01-2023)“…The cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) palbociclib is administered orally and cyclically, causing medication adherence challenges. We evaluated…”
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Suivi thérapeutique pharmacologique à la 4 e journée de pharmacologie des anti-tumoraux
Published in Bulletin du cancer (01-09-2017)Get full text
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Suivi thérapeutique pharmacologique à la 4e journée de pharmacologie des anti-tumoraux
Published in Bulletin du cancer (01-09-2017)Get full text
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Therapeutic drug monitoring - 4th edition of the congress of pharmacology of anticancer drugs
Published in Bulletin du cancer (01-09-2017)Get more information
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Infant exposure to Fluvoxamine through placenta and human milk: a case series - A contribution from the ConcePTION project
Published in Frontiers in psychiatry (01-01-2023)“…IntroductionFluvoxamine is widely used to treat depression during pregnancy and lactation. However, limited data are available on its transfer to the fetus or…”
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