Search Results - "Cardoso, Angelo"

Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88 by Zhang, Huajia, Rodriguez, Sonia, Wang, Lin, Wang, Soujuan, Serezani, Henrique, Kapur, Reuben, Cardoso, Angelo A., Carlesso, Nadia

“…Toll-like receptor 4 (TLR4) plays a central role in host responses to bacterial infection, but the precise mechanism(s) by which its downstream signaling…”
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APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival by Cardoso, Angelo A, Jiang, Yanlin, Luo, Meihua, Reed, April M, Shahda, Safi, He, Ying, Maitra, Anirban, Kelley, Mark R, Fishel, Melissa L

“…Pancreatic cancer is a largely incurable disease, and increasing evidence supports strategies targeting multiple molecular mediators of critical functions of…”
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Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in an NF-κB-Dependent Manner by Wang, Lin, Zhang, Huajia, Rodriguez, Sonia, Cao, Liyun, Parish, Jonathan, Mumaw, Christen, Zollman, Amy, Kamoka, Malgorzata M., Mu, Jian, Chen, Danny Z., Srour, Edward F., Chitteti, Brahmananda R., HogenEsch, Harm, Tu, Xiaolin, Bellido, Teresita M., Boswell, H. Scott, Manshouri, Taghi, Verstovsek, Srdan, Yoder, Mervin C., Kapur, Reuben, Cardoso, Angelo A., Carlesso, Nadia

“…The microRNA miR-155 has been implicated in regulating inflammatory responses and tumorigenesis, but its precise role in linking inflammation and cancer has…”
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Large scale active-learning-guided exploration for in vitro protein production optimization by Borkowski, Olivier, Koch, Mathilde, Zettor, Agnès, Pandi, Amir, Batista, Angelo Cardoso, Soudier, Paul, Faulon, Jean-Loup

“…Lysate-based cell-free systems have become a major platform to study gene expression but batch-to-batch variation makes protein production difficult to…”
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Euclid: A Fully In-Network, P4-Based Approach for Real-Time DDoS Attack Detection and Mitigation by Ilha, Alexandre da Silveira, Lapolli, Angelo Cardoso, Marques, Jonatas Adilson, Gaspary, Luciano Paschoal

“…Distributed Denial-of-Service (DDoS) attacks have been steadily escalating in frequency, scale, and disruptiveness-with outbreaks reaching multiple terabits…”
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Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence by Yoshimoto, Momoko, Porayette, Prashanth, Glosson, Nicole L., Conway, Simon J., Carlesso, Nadia, Cardoso, Angelo A., Kaplan, Mark H., Yoder, Mervin C.

“…The extra-embryonic yolk sac (YS) is the first hematopoietic site in the mouse embryo and is thought to generate only primitive erythroid and myeloerythroid…”
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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability by Silva, Ana, Yunes, J Andrés, Cardoso, Bruno A, Martins, Leila R, Jotta, Patrícia Y, Abecasis, Miguel, Nowill, Alexandre E, Leslie, Nick R, Cardoso, Angelo A, Barata, Joao T

“…Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein deletion and subsequent activation of the PI3K/Akt signaling pathway are…”
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HIV-1 Remission after Allogeneic Hematopoietic-Cell Transplantation by Dickter, Jana K., Aribi, Ahmed, Cardoso, Angelo A., Gianella, Sara, Gendzekhadze, Ketevan, Li, Shirley, Feng, Ye, Chaillon, Antoine, Laird, Gregory M., Browning, Diana L., Ross, Justine A., Nanayakkara, Deepa D., Puing, Alfredo, Stan, Rodica, Lai, Lily L., Chang, Sue, Kadambi, Trilokesh D., Thomas, Sandra, Al Malki, Monzr M., Nakamura, Ryo, Alvarnas, Joseph, Taplitz, Randy A., Dadwal, Sanjeet S., Forman, Stephen J., Zaia, John A.

“…A patient with a 33-year history of HIV-1 infection who underwent stem-cell transplantation for the treatment of acute myelogenous leukemia remained HIV-1 free…”
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Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium by Kim, Young-Woong, Zara, Greta, Kang, HyunJun, Branciamore, Sergio, O’Meally, Denis, Feng, Yuxin, Kuan, Chia-Yi, Luo, Yingjun, Nelson, Michael S., Brummer, Alex B., Rockne, Russell, Chen, Zhen Bouman, Zheng, Yi, Cardoso, Angelo A., Carlesso, Nadia

“…Heterogeneity of endothelial cell (EC) populations reflects their diverse functions in maintaining tissue’s homeostasis. However, their phenotypic, molecular,…”
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Structural and functional characterization of endothelial microparticles released by cigarette smoke by Serban, Karina A., Rezania, Samin, Petrusca, Daniela N., Poirier, Christophe, Cao, Danting, Justice, Matthew J., Patel, Milan, Tsvetkova, Irina, Kamocki, Krzysztof, Mikosz, Andrew, Schweitzer, Kelly S., Jacobson, Sean, Cardoso, Angelo, Carlesso, Nadia, Hubbard, Walter C., Kechris, Katerina, Dragnea, Bogdan, Berdyshev, Evgeny V., McClintock, Jeanette, Petrache, Irina

“…Circulating endothelial microparticles (EMPs) are emerging as biomarkers of chronic obstructive pulmonary disease (COPD) in individuals exposed to cigarette…”
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Stem cell regulatory niches and their role in normal and malignant hematopoiesis by Carlesso, Nadia, Cardoso, Angelo A

“…PURPOSE OF REVIEWIn the postnatal life, hematopoietic stem cell (HSC) niches are specialized microenvironments in the bone marrow that are essential for the…”
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Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL by Rodriguez, Sonia, Abundis, Christina, Boccalatte, Francesco, Mehrotra, Purvi, Chiang, Mark Y., Yui, Mary A., Wang, Lin, Zhang, Huajia, Zollman, Amy, Bonfim-Silva, Ricardo, Kloetgen, Andreas, Palmer, Joycelynne, Sandusky, George, Wunderlich, Mark, Kaplan, Mark H., Mulloy, James C., Marcucci, Guido, Aifantis, Iannis, Cardoso, Angelo A., Carlesso, Nadia

“…Timed degradation of the cyclin-dependent kinase inhibitor p27 Kip1 by the E3 ubiquitin ligase F-box protein SKP2 is critical for T-cell progression into cell…”
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Engineered extracellular vesicles directed to the spike protein inhibit SARS-CoV-2 by Scott, Tristan A., Supramaniam, Aroon, Idris, Adi, Cardoso, Angelo A., Shrivastava, Surya, Kelly, Gabrielle, Grepo, Nicole A., Soemardy, Citradewi, Ray, Roslyn M., McMillan, Nigel A.J., Morris, Kevin V.

“…SARS-CoV-2 (CoV-2) viral infection results in COVID-19 disease, which has caused significant morbidity and mortality worldwide. A vaccine is crucial to curtail…”
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Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival by Maia, Sara, Pelletier, Marc, Ding, Jixin, Hsu, Yen-Ming, Sallan, Stephen E, Rao, Sambasiva P, Nadler, Lee M, Cardoso, Angelo A

“…Despite exhibiting oncogenic events, patient's leukemia cells are responsive and dependent on signals from their malignant bone marrow (BM) microenvironment,…”
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Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma by Xu, Linlin, Mohammad, Khalid S, Wu, Hao, Crean, Colin, Poteat, Bradley, Cheng, Yinghua, Cardoso, Angelo A, Machal, Christophe, Hanenberg, Helmut, Abonour, Rafat, Kacena, Melissa A, Chirgwin, John, Suvannasankha, Attaya, Srour, Edward F

“…Multiple myeloma is incurable once osteolytic lesions have seeded at skeletal sites, but factors mediating this deadly pathogenic advance remain poorly…”
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CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche by Chitteti, Brahmananda Reddy, Kobayashi, Michihiro, Cheng, Yinghua, Zhang, Huajia, Poteat, Bradley A., Broxmeyer, Hal E., Pelus, Louis M., Hanenberg, Helmut, Zollman, Amy, Kamocka, Malgorzata M., Carlesso, Nadia, Cardoso, Angelo A., Kacena, Melissa A., Srour, Edward F.

“…We previously showed that immature CD166+ osteoblasts (OB) promote hematopoietic stem cell (HSC) function. Here, we demonstrate that CD166 is a functional HSC…”
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Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia by Ding, Jixin, Fishel, Melissa L, Reed, April M, McAdams, Erin, Czader, Magdalena B, Cardoso, Angelo A, Kelley, Mark R

“…The increasing characterization of childhood acute lymphoblastic leukemia (ALL) has led to the identification of multiple molecular targets but has yet to…”
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Delta-like 4 induces notch signaling in macrophages : Implications for inflammation by FUNG, Erik, TANG, Sai-Man Timothy, CANNER, James P, MORISHIGE, Kunio, ARBOLEDA-VELASQUEZ, Joseph F, CARDOSO, Angelo A, CARLESSO, Nadia, ASTER, Jon C, AIKAWA, Masanori

“…Activated macrophages contribute to the pathogenesis of inflammatory diseases such as atherosclerosis. Although Notch signaling participates in various aspects…”
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The Earliest T-Precursors in the Mouse Embryo Are Susceptible to Leukemic Transformation by Ding, Jixin, Cardoso, Angelo A, Yoshimoto, Momoko, Kobayashi, Michihiro

“…Acute lymphoblastic leukemia (ALL) is the most common malignancy in pediatric patients. About 10-15% of pediatric ALL belong to T-cell ALL (T-ALL), which is…”
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Smooth Muscle Cells Orchestrate the Endothelial Cell Response to Flow and Injury by BALCELLS, Mercedes, MARTORELL, Jordi, OLIVE, Carla, SANTACANA, Marina, CHITALIA, Vipul, CARDOSO, Angelo A, EDELMAN, Elazer R

“…Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but…”
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