Search Results - "Cardoso, Ana L."

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies by Guedes, Joana R, Lao, Taotao, Cardoso, Ana L, El Khoury, Joseph

“…Chemokines and their receptors have been shown to affect amyloid-β (Aβ) and tau pathologies in mouse models of Alzheimer's disease (AD) by regulating microglia…”
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miR‐155 modulates microglia‐mediated immune response by down‐regulating SOCS‐1 and promoting cytokine and nitric oxide production by Cardoso, Ana L., Guedes, Joana R., Pereira de Almeida, Luís, Pedroso de Lima, Maria C.

“…Summary Innate immunity constitutes the first line of defence against both external and endogenous threats in the brain, and microglia cells are considered key…”
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Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model by Guedes, Joana R, Custódia, Carlos M, Silva, Ricardo J, de Almeida, Luís P, Pedroso de Lima, Maria C, Cardoso, Ana L

“…MicroRNAs (miRNAs) have emerged as a class of small, endogenous, regulatory RNAs that exhibit the ability to epigenetically modulate the translation of mRNAs…”
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Aziridines in Formal [3+2] Cycloadditions: Synthesis of Five-Membered Heterocycles by Cardoso, Ana L., Pinho e Melo, Teresa M. V. D.

“…Chemistry based on ring opening of aziridines has been widely studied in organic synthesis. However, it has mainly been centered on ring opening by…”
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Diels-Alder Cycloaddition Reactions in Sustainable Media by Soares, Maria I L, Cardoso, Ana L, Pinho E Melo, Teresa M V D

“…Diels-Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most…”
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Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression by Cardoso, Ana M, Morais, Catarina M, Cruz, A. Rita, Cardoso, Ana L, Silva, Sandra G, do Vale, M. Luísa, Marques, Eduardo F, Pedroso de Lima, Maria C, Jurado, Amália S

“…Gene delivery targeting mitochondria has the potential to transform the therapeutic landscape of mitochondrial genetic diseases. Taking advantage of the…”
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Cell-penetrating peptides as nucleic acid delivery systems: from biophysics to biological applications by Trabulo, Sara, Cardoso, Ana L, Cardoso, Ana M S, Morais, Catarina M, Jurado, Amalia S, Pedroso de Lima, Maria C

“…The increasing knowledge on the genetic basis of disease has allowed the development of promising gene-targeted therapies that can be applied to numerous…”
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MicroRNAs in glioblastoma: role in pathogenesis and opportunities for targeted therapies by Costa, Pedro M, Cardoso, Ana L, Mano, Miguel, de Lima, Maria C Pedroso

“…Glioblastoma (GBM) is among the most lethal human cancers, being generally characterized by rapid diffuse and infiltrative growth and high level of cellular…”
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Selective Synthesis of 3‑(1H‑Tetrazol-5-yl)-indoles from 2H‑Azirines and Arynes by Grosso, Carla, Alves, Cláudia, Sase, Terver J., Alves, Nuno G., Cardoso, Ana L., Lemos, Américo, Pinho e Melo, Teresa M. V. D.

“…A new selective synthetic approach to indole derivatives bearing a tetrazole moiety has been developed. Arynes, generated in situ from o-(trimethylsilyl)­aryl…”
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Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment by Costa, Pedro M, Cardoso, Ana L, Mendonça, Liliana S, Serani, Angelo, Custódia, Carlos, Conceição, Mariana, Simões, Sérgio, Moreira, João N, Pereira de Almeida, Luís, Pedroso de Lima, Maria C

“…The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this…”
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MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease by Guedes, Joana R, Santana, Isabel, Cunha, Catarina, Duro, Diana, Almeida, Maria R, Cardoso, Ana M, de Lima, Maria C. Pedroso, Cardoso, Ana L

“…Abstract Introduction Mononuclear phagocytes play a critical role during Alzheimer's disease (AD) pathogenesis due to their contribution to innate immune…”
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Synthesis of New 2-Halo-2-(1H-tetrazol-5-yl)-2H-azirines via a Non-Classical Wittig Reaction by Cardoso, Ana L, Sousa, Carmo, Henriques, Marta S C, Paixão, José A, Pinho e Melo, Teresa M V D

“…The synthesis and reactivity of tetrazol-5-yl-phosphorus ylides towards N-halosuccinimide/TMSN₃ reagent systems was explored, opening the way to new…”
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Application of Thermoresponsive PNIPAAM‑b‑PAMPTMA Diblock Copolymers in siRNA Delivery by Cardoso, Ana M, Calejo, M. Teresa, Morais, Catarina M, Cardoso, Ana L, Cruz, Rita, Zhu, Kaizheng, Pedroso de Lima, Maria C, Jurado, Amália S, Nyström, Bo

“…Gene knockdown has emerged as an important tool for cancer gene therapy as well as for viral infections and dominantly inherited genetic disorders. The…”
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Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS by Simões, Carlos J. V., Almeida, Zaida L., Cardoso, Ana L., Bezerra, Filipa, Almeida, Maria R., Beirão, João, Pinho e Melo, Teresa M. V. D., Saraiva, Maria J., Brito, Rui M. M.

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MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma by Costa, Pedro M., Cardoso, Ana L., Custódia, Carlos, Cunha, Pedro, Pereira de Almeida, Luís, Pedroso de Lima, Maria C.

“…Malignant brain tumors, including glioblastoma (GBM), are among the most lethal human cancers, due to their tremendous invasive capacity and limited…”
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Recent Advances in the Chemistry of Conjugated Nitrosoalkenes and Azoalkenes by Lopes, Susana M. M, Cardoso, Ana L, Lemos, Américo, Pinho e Melo, Teresa M. V. D

“…This review aims to present the most recent contributions in the chemistry of nitrosoalkenes and azoalkenes, highlighting the chemical behavior that makes them…”
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Microglia‐dependent remodeling of neuronal circuits by Guedes, Joana R., Ferreira, Pedro A., Costa, Jéssica M., Cardoso, Ana L., Peça, João

“…Microglia are tissue‐resident macrophages responsible for the surveillance, neuronal support, and immune defense of the brain parenchyma. Recently, the role…”
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The old guard: Age-related changes in microglia and their consequences by Costa, Jéssica, Martins, Solange, Ferreira, Pedro A., Cardoso, Ana M.S., Guedes, Joana R., Peça, João, Cardoso, Ana L.

“…•The aging process encompasses the development of a heightened inflammatory status in the brain.•Environmental triggers, like stress, infection and poor diet…”
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Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials by Sequeira, Diana B., Oliveira, Ana Rafaela, Seabra, Catarina M., Palma, Paulo J., Ramos, Carlos, Figueiredo, Maria H., Santos, Ana C., Cardoso, Ana L., Peça, João, Santos, João Miguel

“…Objectives To compare the regenerative properties of human stem cells of the apical papilla (SCAPs) embedded in a platelet-rich plasma (PRP) scaffold, when…”
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Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions by Cardoso, Ana L, Guedes, Joana R, de Lima, Maria C Pedroso

“…Highlights • Transcriptome studies suggest miRNAs can be used as microglia phenotype markers. • MiR-124 regulates the quiescent state of microglia in the…”
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