Search Results - "Cardone, Rebecca"

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome by Perry, Rachel J., Peng, Liang, Barry, Natasha A., Cline, Gary W., Zhang, Dongyan, Cardone, Rebecca L., Petersen, Kitt Falk, Kibbey, Richard G., Goodman, Andrew L., Shulman, Gerald I.

“…Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the…”
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Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats by Perry, Rachel J., Rabin-Court, Aviva, Song, Joongyu D., Cardone, Rebecca L., Wang, Yongliang, Kibbey, Richard G., Shulman, Gerald I.

“…Sodium-glucose transport protein 2 (SGLT2) inhibitors are a class of anti-diabetic agents; however, concerns have been raised about their potential to induce…”
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Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health by Abulizi, Abudukadier, Cardone, Rebecca L., Stark, Romana, Lewandowski, Sophie L., Zhao, Xiaojian, Hillion, Joelle, Ma, Lingjun, Sehgal, Raghav, Alves, Tiago C., Thomas, Craig, Kung, Charles, Wang, Bei, Siebel, Stephan, Andrews, Zane B., Mason, Graeme F., Rinehart, Jesse, Merrins, Matthew J., Kibbey, Richard G.

“…The mitochondrial GTP (mtGTP)-dependent phosphoenolpyruvate (PEP) cycle couples mitochondrial PEPCK (PCK2) to pyruvate kinase (PK) in the liver and pancreatic…”
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Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice by Bhat, Neha, Narayanan, Anand, Fathzadeh, Mohsen, Kahn, Mario, Zhang, Dongyan, Goedeke, Leigh, Neogi, Arpita, Cardone, Rebecca L, Kibbey, Richard G, Fernandez-Hernando, Carlos, Ginsberg, Henry N, Jain, Dhanpat, Shulman, Gerald I, Mani, Arya

“…Mutations in Dyrk1b are associated with metabolic syndrome and nonalcoholic fatty liver disease in humans. Our investigations showed that DYRK1B levels are…”
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Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis by Davis, Jeffrey C., Alves, Tiago C., Helman, Aharon, Chen, Jonathan C., Kenty, Jennifer H., Cardone, Rebecca L., Liu, David R., Kibbey, Richard G., Melton, Douglas A.

“…Stem cell-derived β (SC-β) cells could provide unlimited human β cells toward a curative diabetes treatment. Differentiation of SC-β cells yields…”
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120-LB: Small Molecule Activator of Pyruvate Kinase Regulates In Vivo Glucose Homeostasis by ABULIZI, ABUDUKADIER, CARDONE, REBECCA L., SIEBEL, STEPHAN, KUNG, CHARLES, KIBBEY, RICHARD

“…Background: Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type-2 diabetes (T2D). Liver pyruvate kinase (PK) inactivating…”
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316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway by FOSTER, HANNAH R., HO, THUONG, POTAPENKO, EVGENIY, CARDONE, REBECCA L., KIBBEY, RICHARD, MERRINS, MATTHEW J.

“…β-cells use pyruvate kinase to sense nutrients and respond with appropriate insulin secretion. Here, we used β-cell deletion to identify the functions of…”
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Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents by Perry, Rachel J, Cardone, Rebecca L, Petersen, Max C, Zhang, Dongyan, Fouqueray, Pascale, Hallakou-Bozec, Sophie, Bolze, Sébastien, Shulman, Gerald I, Petersen, Kitt Falk, Kibbey, Richard G

“…Imeglimin is a promising new oral antihyperglycemic agent that has been studied in clinical trials as a possible monotherapy or add-on therapy to lower fasting…”
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Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis by Chaube, Balkrishna, Citrin, Kathryn M., Sahraei, Mahnaz, Singh, Abhishek K., de Urturi, Diego Saenz, Ding, Wen, Pierce, Richard W., Raaisa, Raaisa, Cardone, Rebecca, Kibbey, Richard, Fernández-Hernando, Carlos, Suárez, Yajaira

“…Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic functions. However, its cell-specific role in endothelial cells (ECs) function…”
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β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel by Foster, Hannah R, Ho, Thuong, Potapenko, Evgeniy, Sdao, Sophia M, Huang, Shih Ming, Lewandowski, Sophie L, VanDeusen, Halena R, Davidson, Shawn M, Cardone, Rebecca L, Prentki, Marc, Kibbey, Richard G, Merrins, Matthew J

“…Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated K ATP channel closure and insulin secretion. To identify the…”
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Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos by Jesinkey, Sean R., Madiraju, Anila K., Alves, Tiago C., Yarborough, OrLando H., Cardone, Rebecca L., Zhao, Xiaojian, Parsaei, Yassmin, Nasiri, Ali R., Butrico, Gina, Liu, Xinran, Molina, Anthony J., Rountree, Austin M., Neal, Adam S., Wolf, Dane M., Sterpka, John, Philbrick, William M., Sweet, Ian R., Shirihai, Orian H., Kibbey, Richard G.

“…Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential for glucose homeostasis. One key mechanism of β cell nutrient sensing…”
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N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis by Grevengoed, Trisha J., Trammell, Samuel A. J., McKinney, Michele K., Petersen, Natalia, Cardone, Rebecca L., Svenningsen, Jens S., Ogasawara, Daisuke, Nexøe-Larsen, Christina C., Knop, Filip K., Schwartz, Thue W., Kibbey, Richard G., Cravatt, Benjamin F., Gillum, Matthew P.

“…Fatty acid amide hydrolase (FAAH) degrades 2 major classes of bioactive fatty acid amides, the N-acylethanolamines (NAEs) and N-acyl taurines (NATs), in…”
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β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the K ATP channel by Foster, Hannah R, Ho, Thuong, Potapenko, Evgeniy, Sdao, Sophia M, Huang, Shih Ming, Lewandowski, Sophie L, VanDeusen, Halena R, Davidson, Shawn M, Cardone, Rebecca L, Prentki, Marc, Kibbey, Richard G, Merrins, Matthew J

“…Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated K channel closure and insulin secretion. To identify the PK…”
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127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing by FOSTER, HANNAH R., HO, THUONG, POTAPENKO, EVGENIY, LEWANDOWSKI, SOPHIE L., SDAO, SOPHIA, VANDEUSEN, HALENA R., CARDONE, REBECCA L., KIBBEY, RICHARD, MERRINS, MATTHEW J.

“…Pancreatic β-cells couple nutrient metabolism with appropriate insulin secretion. Here, we examined the requirements of pyruvate kinase (PK) isoforms in fuel…”
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369-OR: [1,2-13C2]-L-Glutamine Mass Isotopomers Map Hepatic Mitochondrial Metabolism without Tracer Interference by SIEBEL, STEPHAN, CARDONE, REBECCA L., ABULIZI, ABUDUKADIER, RAAISA, RAAISA, WILLIAMS, RICHARD M., SEHGAL, RAGHAV, BUTRICO, GINA MARIE, CLINE, GARY, ROTHMAN, DOUGLAS L., MASON, GRAEME F., KIBBEY, RICHARD

“…Background: Tracers should be maximally descriptive with minimal interference to the metabolic system of interest. Divergent concepts of in vivo hepatic…”
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CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation by Esteghamat, Fatemehsadat, Broughton, James S., Smith, Emily, Cardone, Rebecca, Tyagi, Tarun, Guerra, Mateus, Szabó, András, Ugwu, Nelson, Mani, Mitra V., Azari, Bani, Kayingo, Gerald, Chung, Sunny, Fathzadeh, Mohsen, Weiss, Ephraim, Bender, Jeffrey, Mane, Shrikant, Lifton, Richard P., Adeniran, Adebowale, Nathanson, Michael H., Gorelick, Fred S., Hwa, John, Sahin-Tóth, Miklós, Belfort-DeAguiar, Renata, Kibbey, Richard G., Mani, Arya

“…Factors that underlie the clustering of metabolic syndrome traits are not fully known. We performed whole-exome sequence analysis in kindreds with extreme…”
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Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production by Gassaway, Brandon M., Cardone, Rebecca L., Padyana, Anil K., Petersen, Max C., Judd, Evan T., Hayes, Sebastian, Tong, Shuilong, Barber, Karl W., Apostolidi, Maria, Abulizi, Abudukadier, Sheetz, Joshua B., Kshitiz, Aerni, Hans R., Gross, Stefan, Kung, Charles, Samuel, Varman T., Shulman, Gerald I., Kibbey, Richard G., Rinehart, Jesse

“…Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL)…”
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Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway by Lewandowski, Sophie L., Cardone, Rebecca L., Foster, Hannah R., Ho, Thuong, Potapenko, Evgeniy, Poudel, Chetan, VanDeusen, Halena R., Sdao, Sophia M., Alves, Tiago C., Zhao, Xiaojian, Capozzi, Megan E., de Souza, Arnaldo H., Jahan, Ishrat, Thomas, Craig J., Nunemaker, Craig S., Davis, Dawn Belt, Campbell, Jonathan E., Kibbey, Richard G., Merrins, Matthew J.

“…Pancreatic β cells couple nutrient metabolism with appropriate insulin secretion. Here, we show that pyruvate kinase (PK), which converts ADP and…”
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Loss of ZNF148 enhances insulin secretion in human pancreatic β cells by de Klerk, Eleonora, Xiao, Yini, Emfinger, Christopher H, Keller, Mark P, Berrios, David I, Loconte, Valentina, Ekman, Axel A, White, Kate L, Cardone, Rebecca L, Kibbey, Richard G, Attie, Alan D, Hebrok, Matthias

“…Insulin secretion from pancreatic β cells is essential to the maintenance of glucose homeostasis. Defects in this process result in diabetes. Identifying…”
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β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses by Emfinger, Christopher H, de Klerk, Eleonora, Schueler, Kathryn L, Rabaglia, Mary E, Stapleton, Donnie S, Simonett, Shane P, Mitok, Kelly A, Wang, Ziyue, Liu, Xinyue, Paulo, Joao A, Yu, Qinq, Cardone, Rebecca L, Foster, Hannah R, Lewandowski, Sophie L, Perales, José C, Kendziorski, Christina M, Gygi, Steven P, Kibbey, Richard G, Keller, Mark P, Hebrok, Matthias, Merrins, Matthew J, Attie, Alan D

“…Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We…”
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