Search Results - "Cardiff, Robert"

Manual hematoxylin and eosin staining of mouse tissue sections by Cardiff, Robert D, Miller, Claramae H, Munn, Robert J

“…The hematoxylin and eosin (H&E) stain is the standard used for microscopic examination of tissues that have been fixed, processed, embedded, and sectioned. It…”
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Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies by Jeon, Young Joo, Khelifa, Sihem, Ratnikov, Boris, Scott, David A., Feng, Yongmei, Parisi, Fabio, Ruller, Chelsea, Lau, Eric, Kim, Hyungsoo, Brill, Laurence M., Jiang, Tingting, Rimm, David L., Cardiff, Robert D., Mills, Gordon B., Smith, Jeffrey W., Osterman, Andrei L., Kluger, Yuval, Ronai, Ze’ev A.

“…Many tumor cells are fueled by altered metabolism and increased glutamine (Gln) dependence. We identify regulation of the L-glutamine carrier proteins SLC1A5…”
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PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours by Koren, Shany, Reavie, Linsey, Couto, Joana Pinto, De Silva, Duvini, Stadler, Michael B, Roloff, Tim, Britschgi, Adrian, Eichlisberger, Tobias, Kohler, Hubertus, Aina, Olulanu, Cardiff, Robert D, Bentires-Alj, Mohamed

“…The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor…”
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Methods of Immunohistochemistry and Immunofluorescence: Converting Invisible to Visible by Mori, Hidetoshi, Cardiff, Robert D

“…Observing changes in pathophysiological tissue samples often relies on immunohistochemical or immunofluorescence analysis. These techniques show target…”
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The E2F Transcription Factors Regulate Tumor Development and Metastasis in a Mouse Model of Metastatic Breast Cancer by Hollern, Daniel P., Honeysett, Jordan, Cardiff, Robert D., Andrechek, Eran R.

“…While the E2F transcription factors (E2Fs) have a clearly defined role in cell cycle control, recent work has uncovered new functions. Using genomic signature…”
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Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity by Wang, Zhu A., Mitrofanova, Antonina, Bergren, Sarah K., Abate-Shen, Cory, Cardiff, Robert D., Califano, Andrea, Shen, Michael M.

“…A key issue in cancer biology is whether oncogenic transformation of different cell types of origin within an adult tissue gives rise to distinct tumour…”
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The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression by Olson, Adam, Le, Vien, Aldahl, Joseph, Yu, Eun-Jeong, Hooker, Erika, He, Yongfeng, Lee, Dong-Hong, Kim, Won Kyung, Cardiff, Robert D, Geradts, Joseph, Sun, Zijie

“…E-cadherin complexes with the actin cytoskeleton via cytoplasmic catenins and maintains the functional characteristics and integrity of the epithelia in normal…”
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Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee by ITTMANN, Michael, JIAOTI HUANG, LODA, Massimo, THOMAS, George, BOROWSKY, Alexander, CARDIFF, Robert D, RADAELLI, Enrico, MARTIN, Philip, SIGNORETTI, Sabina, SULLIVAN, Ruth, SIMONS, Brian W, WARD, Jerrold M, ROBINSON, Brian D, CHU, Gerald C

“…Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue…”
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Insights from transgenic mouse models of ERBB2-induced breast cancer by Muller, William J, Ursini-Siegel, Josie, Schade, Babette, Cardiff, Robert D

“…One-third of patients with breast cancer overexpress the ERBB2 receptor tyrosine kinase, which is associated not only with a more aggressive phenotype but also…”
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Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors by Qi, Jianfei, Nakayama, Koh, Cardiff, Robert D., Borowsky, Alexander D., Kaul, Karen, Williams, Roy, Krajewski, Stan, Mercola, Dan, Carpenter, Philip M., Bowtell, David, Ronai, Ze'ev A.

“…Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation…”
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Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells by Rädler, Patrick D., Wehde, Barbara L., Triplett, Aleata A., Shrestha, Hridaya, Shepherd, Jonathan H., Pfefferle, Adam D., Rui, Hallgeir, Cardiff, Robert D., Perou, Charles M., Wagner, Kay-Uwe

“…Claudin-low breast cancer represents an aggressive molecular subtype that is comprised of mostly triple-negative mammary tumor cells that possess stem…”
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Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression by Lahlou, Hicham, Sanguin-Gendreau, Virginie, Zuo, Dongmei, Cardiff, Robert.D, McLean, Gordon W, Frame, Margaret C, Muller, William J

“…Elevated expression and activation of the focal adhesion kinase (FAK) occurs in a large proportion of human breast cancers. Although several studies have…”
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STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas by Chan, Szeman Ruby, Vermi, William, Luo, Jingqin, Lucini, Laura, Rickert, Charles, Fowler, Amy M, Lonardi, Silvia, Arthur, Cora, Young, Larry Jt, Levy, David E, Welch, Michael J, Cardiff, Robert D, Schreiber, Robert D

“…Although breast cancers expressing estrogen receptor-α (ERα) and progesterone receptors (PR) are the most common form of mammary malignancy in humans, it has…”
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Timeline: Insights from transgenic mouse models of ERBB2-induced breast cancer by Ursini-Siegel, Josie, Schade, Babette, Cardiff, Robert D, Muller, William J

“…One-third of patients with breast cancer overexpress the ERBB2 receptor tyrosine kinase, which is associated not only with a more aggressive phenotype but also…”
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ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer by Aytes, Alvaro, Mitrofanova, Antonina, Kinkade, Carolyn Waugh, Lefebvre, Celine, Lei, Ming, Phelan, Vanessa, LeKaye, H Carl, Koutcher, Jason A, Cardiff, Robert D, Califano, Andrea, Shen, Michael M, Abate-Shen, Cory

“…Combinatorial activation of PI3-kinase and RAS signaling occurs frequently in advanced prostate cancer and is associated with adverse patient outcome. We now…”
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Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis by Sawyers, Charles L, King, Jennifer C, Xu, Jin, Wongvipat, John, Hieronymus, Haley, Carver, Brett S, Leung, David H, Taylor, Barry S, Sander, Chris, Cardiff, Robert D, Couto, Suzana S, Gerald, William L

“…The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about…”
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Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors by Zhang, Jin, Xu, Enshun, Ren, Cong, Yan, Wensheng, Zhang, Min, Chen, Mingyi, Cardiff, Robert D., Imai, Denise M., Wisner, Erik, Chen, Xinbin

“…Significance RNA-binding motif protein 38 (Rbm38) is a target of the p53 family and modulates p53 expression via mRNA translation. However, the biological…”
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Editor's Note: Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model by Floc'h, Nicola, Kinkade, Carolyn Waugh, Kobayashi, Takashi, Aytes, Alvaro, Lefebvre, Celine, Mitrofanova, Antonina, Cardiff, Robert D, Califano, Andrea, Shen, Michael M, Abate-Shen, Cory

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Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors by MEYER, Dominique S, BRINKHAUS, Heike, MÜLLER, Urs, MÜLLER, Matthias, CARDIFF, Robert D, BENTIRES-ALJ, Mohamed

“…The phosphoinositide 3-kinase (PI3K) signaling cascade, a key mediator of cellular survival, growth, and metabolism, is frequently altered in human cancer…”
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The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis by Fifield, Bre-Anne, Qemo, Ingrid, Kirou, Evie, Cardiff, Robert D, Porter, Lisa Ann

“…Breast cancer is the most common cancer to affect women and one of the leading causes of cancer-related deaths. Proper regulation of cell cycle checkpoints…”
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