Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA

Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA

The cross-immunity between tuberculosis and leprosy is unknown. The aim of this pilot study was to evaluate the occurrence of Mycobacterium tuberculosis and M. leprae infection in Marshallese adult volunteers in Springdale, Arkansas, U.S.A., a population that experiences high rates of leprosy and tu...

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Bibliographic Details
Published in:Leprosy review Vol. 87; no. 1; pp. 109 - 112
Main Authors: Cardenas, Victor Manuel, Orloff, Mohammed S, Kaminaga, Joseph, Cardenas, Irma Carrillo, Brown, Joeline, Hainline-Williams, Sandra, Duthie, Malcolm S, Gonzalez-Puche, Angela C, Mukasa, Leonard, Patil, Naveen, Mcelfish, Pearl Ann, Bates, Joseph H
Format: Journal Article
Language:English
Published: England British Leprosy Relief Association 01-03-2016
Subjects:
Adolescent
Adult
Aged
Analysis
Arkansas - epidemiology
Care and treatment
Diagnosis
Enzyme-linked immunosorbent assay
Humans
Leprosy
Leprosy - epidemiology
Leprosy - ethnology
Middle Aged
Pilot Projects
Tuberculosis
Tuberculosis - epidemiology
Tuberculosis - ethnology
Young Adult
Arkansas
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Summary:The cross-immunity between tuberculosis and leprosy is unknown. The aim of this pilot study was to evaluate the occurrence of Mycobacterium tuberculosis and M. leprae infection in Marshallese adult volunteers in Springdale, Arkansas, U.S.A., a population that experiences high rates of leprosy and tuberculosis. We used immunodiagnostic testing for tuberculosis and leprosy infection and found significant prevalence of latent tuberculosis infection (19.0%), and asymptomatic Mycobacterium leprae infection (22.2%). We found a negative association between presence of antibodies to Mycobacterium leprae and a positive interferon-γ release assay for Mycobacterium tuberculosis infection, prevalence odds ratio = 0.1 (95% CI = 0.0, 0.9). Although these findings require confirmation on a larger scale, they are supportive of the existence of cross-immunity.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0305-7518
2162-8807
2162-8807
DOI:10.47276/lr.87.1.109