Search Results - "Cardenas, Horacio"

Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells by Tan, Yuying, Li, Junjie, Zhao, Guangyuan, Huang, Kai-Chih, Cardenas, Horacio, Wang, Yinu, Matei, Daniela, Cheng, Ji-Xin

“…Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic reprograming during therapeutic resistance development is under-studied…”
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Epigenetic priming enhances antitumor immunity in platinum-resistant ovarian cancer by Chen, Siqi, Xie, Ping, Cowan, Matthew, Huang, Hao, Cardenas, Horacio, Keathley, Russell, Tanner, Edward J, Fleming, Gini F, Moroney, John W, Pant, Alok, Akasha, Azza M, Davuluri, Ramana V, Kocherginsky, Masha, Zhang, Bin, Matei, Daniela

“…BackgroundImmune checkpoint inhibitors (ICIs) have modest activity in ovarian cancer (OC). To augment their activity, we used priming with the hypomethylating…”
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EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells by Cardenas, Horacio, Zhao, Janice, Vieth, Edyta, Nephew, Kenneth P, Matei, Daniela

“…Cancer cells acquire essential characteristics for metastatic dissemination through the process of epithelial-to-mesenchymal transition (EMT), which is…”
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In vivo tumor growth of high-grade serous ovarian cancer cell lines by Mitra, Anirban K, Davis, David A, Tomar, Sunil, Roy, Lynn, Gurler, Hilal, Xie, Jia, Lantvit, Daniel D, Cardenas, Horacio, Fang, Fang, Liu, Yueying, Loughran, Elizabeth, Yang, Jing, Sharon Stack, M, Emerson, Robert E, Cowden Dahl, Karen D, V. Barbolina, Maria, Nephew, Kenneth P, Matei, Daniela, Burdette, Joanna E

“…Abstract Objective Genomic studies of ovarian cancer (OC) cell lines frequently used in research revealed that these cells do not fully represent high-grade…”
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Methylomic Signatures of High Grade Serous Ovarian Cancer by Cardenas, Horacio, Fang, Fang, Jiang, Guanglong, Perkins, Susan M., Zhang, Chi, Emerson, Robert E., Hutchins, George, Keer, Harold N., Liu, Yunlong, Matei, Daniela, Nephew, Kenneth

“…High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features, including DNA methylation. In this study we delineate pathways and networks…”
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Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function by Cardenas, Horacio, Arango, Daniel, Nicholas, Courtney, Duarte, Silvia, Nuovo, Gerard J, He, Wei, Voss, Oliver H, Gonzalez-Mejia, M Elba, Guttridge, Denis C, Grotewold, Erich, Doseff, Andrea I

“…The increasing prevalence of inflammatory diseases and the adverse effects associated with the long-term use of current anti-inflammatory therapies prompt the…”
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E2F1 mediates competition, proliferation and response to cisplatin in cohabitating resistant and sensitive ovarian cancer cells by Valdivia, Andres, Cowan, Matthew, Cardenas, Horacio, Isac, Ana Maria, Zhao, Guangyuan, Huang, Hao, Matei, Daniela

“…Tumor heterogeneity is one of the key factors leading to chemo-resistance relapse. It remains unknown how resistant cancer cells influence sensitive cells…”
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Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer by Lee, Jiyoon, Yakubov, Bakhtiyor, Ivan, Cristina, Jones, David R, Caperell-Grant, Andrea, Fishel, Melissa, Cardenas, Horacio, Matei, Daniela

“…Abstract Resistance to chemotherapy is a hallmark of pancreatic ductal adenocarcinoma (PDA) and has been partly attributed to the dense desmoplastic stroma,…”
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Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer by Sima, Livia Elena, Chen, Siqi, Cardenas, Horacio, Zhao, Guangyuan, Wang, Yinu, Ivan, Cristina, Huang, Hao, Zhang, Bin, Matei, Daniela

“…BackgroundTissue transglutaminase (TG2), an enzyme overexpressed in cancer cells, promotes metastasis and resistance to chemotherapy. Its distinct effects in…”
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Nanoparticle Targeting in Chemo‐Resistant Ovarian Cancer Reveals Dual Axis of Therapeutic Vulnerability Involving Cholesterol Uptake and Cell Redox Balance by Wang, Yinu, Calvert, Andrea E., Cardenas, Horacio, Rink, Jonathon S., Nahotko, Dominik, Qiang, Wenan, Ndukwe, C. Estelle, Chen, Fukai, Keathley, Russell, Zhang, Yaqi, Cheng, Ji‐Xin, Thaxton, C. Shad, Matei, Daniela

“…Platinum (Pt)‐based chemotherapy is the main treatment for ovarian cancer (OC); however, most patients develop Pt resistance (Pt‐R). This work shows that Pt‐R…”
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Information policies and libraries, beginning at the beginning by Zardoni, Horacio Cardenas

“…Information policies do not occur in the abstract, as part of a theory or science of information, they do not exist in isolation, isolated from the organized…”
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Ovarian Cancer-Why Lipids Matter by Zhao, Guangyuan, Cardenas, Horacio, Matei, Daniela

“…This review highlights recent advances in the understanding of the relevance of altered lipid metabolic pathways contributing to the poor prognosis of high…”
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Políticas de información y biblioteca, comenzando por el principio by Cardenas Zardoni, Horacio

“…Las políticas de la información no ocurren en abstracto, como parte de una teoría o de las ciencias de la información, tampoco se dan aisladamente,…”
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FTO-Dependent N 6 -Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling by Huang, Hao, Wang, Yinu, Kandpal, Manoj, Zhao, Guangyuan, Cardenas, Horacio, Ji, Yanrong, Chaparala, Anusha, Tanner, Edward J, Chen, Jianjun, Davuluri, Ramana V, Matei, Daniela

“…-Methyladenosine (m A) is the most abundant modification of mammalian mRNAs. RNA methylation fine tunes RNA stability and translation, altering cell fate. The…”
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Protective Effects of Estrogen in a Rat Model of Age-Related Cataracts by Bigsby, Robert M., Cardenas, Horacio, Caperell-Grant, Andrea, Grubbs, Clinton J.

“…Women have a higher incidence of cataracts, and epidemiologic data suggest that the increased risk may be caused by a lack of estrogen in postmenopausal years…”
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N6-Methyladenosine RNA Modifications Regulate the Response to Platinum Through Nicotinamide N-methyltransferase by Huang, Hao, Zhao, Guangyuan, Cardenas, Horacio, Valdivia, Andres Felipe, Wang, Yinu, Matei, Daniela

“…Development of resistance to platinum (Pt) in ovarian cancer remains a major clinical challenge. Here we focused on identifying epitranscriptomic modifications…”
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Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis by Wang, Yinu, Zhao, Guangyuan, Condello, Salvatore, Huang, Hao, Cardenas, Horacio, Tanner, Edward J, Wei, JianJun, Ji, Yanrong, Li, Junjie, Tan, Yuying, Davuluri, Ramana V, Peter, Marcus E, Cheng, Ji-Xin, Matei, Daniela

“…Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and…”
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Epigenetic Targeting of Ovarian Cancer Stem Cells by YINU WANG, CARDENAS, Horacio, FANG FANG, CONDELLO, Salvatore, TAVERNA, Pietro, SEGAR, Matthew, YUNLONG LIU, NEPHEW, Kenneth P, MATEI, Daniela

“…Emerging results indicate that cancer stem-like cells contribute to chemoresistance and poor clinical outcomes in many cancers, including ovarian cancer. As…”
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TGF-β induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells by Cardenas, Horacio, Vieth, Edyta, Lee, Jiyoon, Segar, Mathew, Liu, Yunlong, Nephew, Kenneth P, Matei, Daniela

“…A key step in the process of metastasis is the epithelial-to-mesenchymal transition (EMT). We hypothesized that epigenetic mechanisms play a key role in EMT…”
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Immune characterization in platinum resistant ovarian cancer patients treated with pembrolizumab and guadecitabine by xie, ping, Chen, Siqi, Cowan, Mathew, Huang, Hao, Cardenas, Horacio, Kocherginsky, Masha, Matei, Daniela, Zhang, Bin

“…Abstract Immune checkpoint inhibitors (ICI) have limited activity in ovarian cancer (OC). Accumulating preclinical and early clinical results support that…”
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