Search Results - "Cardelli, Luca"
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A programming language for composable DNA circuits
Published in Journal of the Royal Society interface (06-08-2009)“…Recently, a range of information-processing circuits have been implemented in DNA by using strand displacement as their main computational mechanism. Examples…”
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2
The Cell Cycle Switch Computes Approximate Majority
Published in Scientific reports (13-09-2012)“…Both computational and biological systems have to make decisions about switching from one state to another. The ‘Approximate Majority’ computational algorithm…”
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From electric circuits to chemical networks
Published in Natural computing (01-03-2020)“…Electric circuits manipulate electric charge and magnetic flux via a small set of discrete components to implement useful functionality over continuous…”
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The Beacon Calculus: A formal method for the flexible and concise modelling of biological systems
Published in PLoS computational biology (01-03-2020)“…Biological systems are made up of components that change their actions (and interactions) over time and coordinate with other components nearby. Together with…”
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Chemical reaction network designs for asynchronous logic circuits
Published in Natural computing (01-03-2018)“…Chemical reaction networks (CRNs) are a versatile language for describing the dynamical behaviour of chemical kinetics, capable of modelling a variety of…”
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6
Abstractions for DNA circuit design
Published in Journal of the Royal Society interface (07-03-2012)“…DNA strand displacement techniques have been used to implement a broad range of information processing devices, from logic gates, to chemical reaction…”
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7
Design and analysis of DNA strand displacement devices using probabilistic model checking
Published in Journal of the Royal Society interface (07-07-2012)“…Designing correct, robust DNA devices is difficult because of the many possibilities for unwanted interference between molecules in the system. DNA strand…”
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Programmable chemical controllers made from DNA
Published in Nature nanotechnology (29-09-2013)Get full text
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9
Evolution of opposing regulatory interactions underlies the emergence of eukaryotic cell cycle checkpoints
Published in Scientific reports (27-05-2021)“…In eukaryotes the entry into mitosis is initiated by activation of cyclin-dependent kinases (CDKs), which in turn activate a large number of protein kinases to…”
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A Language for Modeling and Optimizing Experimental Biological Protocols
Published in Computation (01-10-2021)“…Automation is becoming ubiquitous in all laboratory activities, moving towards precisely defined and codified laboratory protocols. However, the integration…”
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Biomolecular mechanisms for signal differentiation
Published in iScience (17-12-2021)“…Cells can sense temporal changes of molecular signals, allowing them to predict environmental variations and modulate their behavior. This paper elucidates…”
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Efficient Switches in Biology and Computer Science
Published in PLoS computational biology (01-01-2017)“…Luca Cardelli Affiliations Microsoft Research, Cambridge, United Kingdom, Department of Computer Science, University of Oxford, Oxford, United Kingdom Rosa D…”
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13
Phosphorelays provide tunable signal processing capabilities for the cell
Published in PLoS computational biology (01-11-2013)“…Achieving a complete understanding of cellular signal transduction requires deciphering the relation between structural and biochemical features of a signaling…”
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Transcriptional regulation is a major controller of cell cycle transition dynamics
Published in PloS one (06-01-2012)“…DNA replication, mitosis and mitotic exit are critical transitions of the cell cycle which normally occur only once per cycle. A universal control mechanism…”
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15
Two-Domain DNA Strand Displacement
Published in Electronic proceedings in theoretical computer science (09-06-2010)“…We investigate the computing power of a restricted class of DNA strand displacement structures: those that are made of double strands with nicks…”
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16
A peptide filtering relation quantifies MHC class I peptide optimization
Published in PLoS computational biology (01-10-2011)“…Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing…”
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Morphisms of reaction networks that couple structure to function
Published in BMC systems biology (15-08-2014)“…The mechanisms underlying complex biological systems are routinely represented as networks. Network kinetics is widely studied, and so is the connection…”
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Continuous Markovian Logics - Axiomatization and Quantified Metatheory
Published in Logical methods in computer science (01-01-2012)“…Continuous Markovian Logic (CML) is a multimodal logic that expresses quantitative and qualitative properties of continuous-time labelled Markov processes with…”
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On process rate semantics
Published in Theoretical computer science (14-02-2008)“…We provide translations between process algebra and systems of chemical reactions. We show that the translations preserve discrete-state (stochastic) and…”
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Strand algebras for DNA computing
Published in Natural computing (01-03-2011)“…We present a process algebra for DNA computing, discussing compilation of other formal systems into the algebra, and compilation of the algebra into DNA…”
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