Search Results - "Cardelli, James"

Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols by Shutava, Tatsiana G, Balkundi, Shantanu S, Vangala, Pranitha, Steffan, Joshua J, Bigelow, Rebecca L, Cardelli, James A, O’Neal, D. Patrick, Lvov, Yuri M

“…Natural polyphenols with previously demonstrated anticancer potential, epigallocatechin gallate (EGCG), tannic acid, curcumin, and theaflavin, were encased…”
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Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells by Coleman, David T, Soung, Young Hwa, Surh, Young-Joon, Cardelli, James A, Chung, Jun

“…Curcumin has been shown to mitigate cancer phenotypes such as invasive migration, proliferation, and survival by disrupting numerous signaling pathways. Our…”
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The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-β-induced myofibroblast phenotypes through RhoA and ERK inhibition by Gray, Alana L, Stephens, Charles A, Bigelow, Rebecca L H, Coleman, David T, Cardelli, James A

“…The presence of reactive stroma, predominantly composed of myofibroblasts, is directly associated with and drives prostate cancer progression. We have…”
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Supporting a role for the GTPase Rab7 in prostate cancer progression by Steffan, Joshua J, Dykes, Samantha S, Coleman, David T, Adams, Lisa K, Rogers, Donna, Carroll, Jennifer L, Williams, B Jill, Cardelli, James A

“…Invasion and subsequent metastasis is the major cause of death from most cancers including prostate cancer. Herein we report on the potential tumor suppressive…”
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Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells by Circu, Magdalena, Cardelli, James, Barr, Martin P, O'Byrne, Kenneth, Mills, Glenn, El-Osta, Hazem

“…Lung cancer is the leading cause of cancer-related deaths. Most patients develop resistance to platinum within several months of treatment. We investigated…”
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Lysosome trafficking is necessary for EGF-driven invasion and is regulated by p38 MAPK and Na+/H+ exchangers by Dykes, Samantha S, Steffan, Joshua J, Cardelli, James A

“…Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte…”
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Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro by McLarty, Jerry, Bigelow, Rebecca L H, Smith, Mylinh, Elmajian, Don, Ankem, Murali, Cardelli, James A

“…The purpose of this study was to determine the effects of short-term supplementation with the active compounds in green tea on serum biomarkers in patients…”
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The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo by Dykes, Samantha S, Gray, Alana L, Coleman, David T, Saxena, Madhurima, Stephens, Charles A, Carroll, Jennifer L, Pruitt, Kevin, Cardelli, James A

“…Cancer is a multistep process that requires cells to respond appropriately to the tumor microenvironment, both in early proliferative stages and in later…”
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The Green Tea Polyphenol EGCG Potentiates the Antiproliferative Activity of c-Met and Epidermal Growth Factor Receptor Inhibitors in Non-small Cell Lung Cancer Cells by MILLIGAN, Shawn A, BURKE, Patrick, COLEMAN, David T, BIGELOW, Rebecca L, STEFFAN, Joshua J, CARROLL, Jennifer L, WILLIAMS, Briana Jill, CARDELLI, James A

“…Activation of the c-Met and epidermal growth factor receptors (EGFR) promotes the growth and survival of non-small cell lung cancer (NSCLC). Specific receptor…”
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Palmitoylation regulates the intracellular trafficking and stability of c-Met by Coleman, David T, Gray, Alana L, Kridel, Steven J, Cardelli, James A

“…c-Met is a receptor tyrosine kinase whose activity can promote both mitogenic and motogenic phenotypes involved in tissue development and cancer progression…”
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HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na⁺-H⁺ exchangers by Steffan, Joshua J, Williams, Brittany C, Welbourne, Tomas, Cardelli, James A

“…Hepatocyte growth factor (HGF) is found in tumor microenvironments, and interaction with its tyrosine kinase receptor Met triggers cell invasion and…”
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Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes by Scott, Matthew L., Coleman, David T., Kelly, Kinsey C., Carroll, Jennifer L., Woodby, Brittany, Songock, William K., Cardelli, James A., Bodily, Jason M.

“…Human papillomaviruses (HPVs) cause benign lesions that can lead to malignancy. How cellular changes induced by viral oncogenes contribute to the progeny…”
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Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer by Mohyeldin, Mohamed M., Busnena, Belnaser A., Akl, Mohamed R., Dragoi, Ana Maria, Cardelli, James A., El Sayed, Khalid A.

“…Dysregulated receptor tyrosine kinase c-Met and its ligand HGF is valid and attractive molecular target for therapeutic blockade in cancer. Inspired by the…”
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Na⁺/H⁺ Exchangers and RhoA Regulate Acidic Extracellular pH-Induced Lysosome Trafficking in Prostate Cancer Cells by Steffan, Joshua J, Snider, Jared L, Skalli, Omar, Welbourne, Tomas, Cardelli, James A

“…Acidic extracellular pH (pHe) is a common feature of the tumor microenvironment and has been implicated in tumor invasion through the induction of protease…”
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Monocarboxylate transporter 1 contributes to growth factor-induced tumor cell migration independent of transporter activity by Gray, Alana L, Coleman, David T, Shi, Runhua, Cardelli, James A

“…Tumor progression to metastatic disease contributes to the vast majority of incurable cancer. Understanding the processes leading to advanced stage cancer is…”
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Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation by Coleman, David T, Bigelow, Rebecca, Cardelli, James A

“…The hepatocyte growth factor (HGF)/c-Met signaling pathway is involved in the progression of several cancers and associated with increased tumor invasion and…”
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The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells by Duhon, Damian, Bigelow, Rebecca L. H., Coleman, David T., Steffan, Joshua J., Yu, Chris, Langston, Will, Kevil, Christopher G., Cardelli, James A.

“…The HGF/c‐Met pathway is an important regulator of signaling pathways responsible for invasion and metastasis of most human cancers, including prostate cancer…”
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A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion by Circu, Magdalena L, Dykes, Samantha S, Carroll, Jennifer, Kelly, Kinsey, Galiano, Floyd, Greer, Adam, Cardelli, James, El-Osta, Hazem

“…Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have…”
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Correction: Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells by Circu, Magdalena, Cardelli, James, Barr, Martin P, O'Byrne, Kenneth, Mills, Glenn, El-Osta, Hazem

“…[This corrects the article DOI: 10.1371/journal.pone.0184922.]…”
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Zinc finger E‐box binding homeobox‐1 (Zeb1) drives anterograde lysosome trafficking and tumor cell invasion via upregulation of Na+/H+ Exchanger‐1 (NHE1) by Dykes, Samantha S., Gao, ChongFeng, Songock, William K., Bigelow, Rebecca L., Woude, George Vande, Bodily, Jason M., Cardelli, James A.

“…Tumor cell invasion through the extracellular matrix is facilitated by the secretion of lysosome‐associated proteases. As a common mechanism for secretion,…”
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