Search Results - "Cardarelli, Silvia"

Extracellular Vesicle-Induced Differentiation of Neural Stem Progenitor Cells by Stronati, Eleonora, Conti, Roberta, Cacci, Emanuele, Cardarelli, Silvia, Biagioni, Stefano, Poiana, Giancarlo

“…Neural stem progenitor cells (NSPCs) from E13.5 mouse embryos can be maintained in culture under proliferating conditions. Upon growth-factor removal, they may…”
Get full text

Phosphodiesterase Inhibitors: Could They Be Beneficial for the Treatment of COVID-19? by Giorgi, Mauro, Cardarelli, Silvia, Ragusa, Federica, Saliola, Michele, Biagioni, Stefano, Poiana, Giancarlo, Naro, Fabio, Massimi, Mara

“…In March 2020, the World Health Organization declared the severe acute respiratory syndrome corona virus 2 (SARS-CoV2) infection to be a pandemic disease…”
Get full text

Structural Characterization of Murine Phosphodiesterase 5 Isoforms and Involvement of Cysteine Residues in Supramolecular Assembly by Giorgi, Mauro, Miele, Adriana Erica, Cardarelli, Silvia, Giorgi, Alessandra, Massimi, Mara, Biagioni, Stefano, Saliola, Michele

“…Phosphodiesterases (PDEs) are a superfamily of evolutionarily conserved cyclic nucleotide (cAMP/cGMP)-hydrolyzing enzymes, components of transduction pathways…”
Get full text

Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms by Cardarelli, Silvia, Miele, Adriana Erica, Campolo, Federica, Massimi, Mara, Mancini, Patrizia, Biagioni, Stefano, Naro, Fabio, Giorgi, Mauro, Saliola, Michele

“…3′-5′ cyclic nucleotide phosphodiesterases (PDEs) are a family of evolutionarily conserved cAMP and/or cGMP hydrolyzing enzymes, components of transduction…”
Get full text

Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress by Cardarelli, Silvia, Biglietto, Martina, Orsini, Tiziana, Fustaino, Valentina, Monaco, Lucia, de Oliveira do Rêgo, Ana Gabriela, Liccardo, Francesca, Masciarelli, Silvia, Fazi, Francesco, Naro, Fabio, De Angelis, Luciana, Pellegrini, Manuela

“…Phosphodiesterase 2A (Pde2A) is a dual-specific PDE that breaks down both cAMP and cGMP cyclic nucleotides. We recently highlighted a direct relationship…”
Get full text

Evaluation of the Therapeutic Effects of Harmine on Anaplastic Thyroid Cancer Cells by Baldini, Enke, Cardarelli, Silvia, Campese, Antonio Francesco, Lori, Eleonora, Fallahi, Poupak, Virili, Camilla, Forte, Flavio, Pironi, Daniele, Di Matteo, Filippo Maria, Palumbo, Piergaspare, Costanzo, Maria Ludovica, D'Andrea, Vito, Centanni, Marco, Sorrenti, Salvatore, Antonelli, Alessandro, Ulisse, Salvatore

“…Anaplastic thyroid carcinoma (ATC) is an extremely difficult disease to tackle, with an overall patient survival of only a few months. The currently used…”
Get full text

Neurotrophins as Therapeutic Agents for Parkinson's Disease; New Chances From Focused Ultrasound? by Stefani, Alessandro, Pierantozzi, Mariangela, Cardarelli, Silvia, Stefani, Lucrezia, Cerroni, Rocco, Conti, Matteo, Garasto, Elena, Mercuri, Nicola B, Marini, Carmine, Sucapane, Patrizia

“…Magnetic Resonance-guided Focused Ultrasound (MRgFUS) represents an effective micro-lesioning approach to target pharmaco-resistant tremor, mostly in patients…”
Get full text

A2A Receptor Dysregulation in Dystonia DYT1 Knock-Out Mice by D'Angelo, Vincenza, Giorgi, Mauro, Paldino, Emanuela, Cardarelli, Silvia, Fusco, Francesca R, Saverioni, Ilaria, Sorge, Roberto, Martella, Giuseppina, Biagioni, Stefano, Mercuri, Nicola B, Pisani, Antonio, Sancesario, Giuseppe

“…We aimed to investigate A2A receptors in the basal ganglia of a DYT1 mouse model of dystonia. A2A was studied in control Tor1a+/+ and Tor1a+/- knock-out mice…”
Get full text

Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder by Schiavi, Sara, Carbone, Emilia, Melancia, Francesca, di Masi, Alessandra, Jarjat, Marielle, Brau, Fréderic, Cardarelli, Silvia, Giorgi, Mauro, Bardoni, Barbara, Trezza, Viviana

“…Pharmacological inhibition of phosphodiesterase 2A (PDE2A), which catalyzes the hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine…”
Get full text

Phosphodiesterases Expression during Murine Cardiac Development by Carvalho, Thays Maria da Conceição Silva, Cardarelli, Silvia, Giorgi, Mauro, Lenzi, Andrea, Isidori, Andrea M, Naro, Fabio

“…3'-5' cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes playing a fundamental role in the control of intracellular levels of cAMP and…”
Get full text

Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone by Poiana, Giancarlo, Gioia, Roberta, Sineri, Serena, Cardarelli, Silvia, Lupo, Giuseppe, Cacci, Emanuele

“…In rodents, well characterized neurogenic niches of the adult brain, such as the subventricular zone of the lateral ventricles and the subgranular zone of the…”
Get full text

Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis by Cardarelli, Silvia, Giorgi, Mauro, Naro, Fabio, Malatesta, Francesco, Biagioni, Stefano, Saliola, Michele

“…Phosphodiesterases (PDE) are a superfamily of enzymes that hydrolyse cyclic nucleotides (cAMP/cGMP), signal molecules in transduction pathways regulating…”
Get full text

Iodized Salt May Not Be Sufficient to Guarantee an Adequate Iodine Intake in Pregnant Women by Spina, Vincenzo, Baldini, Enke, Cardarelli, Silvia, Oliva, Cosimo, Venarubea, Stefano, Faraoni, Franca, Pastore, Giovanni, Tittoni, Rachele, Musella, Angela, Squarcella, Antonia, Lori, Eleonora, Renzi, Elisabetta, Feroci, Roberta, Mastrodonato, Flavia, Ciferri, Fabiola, Virili, Camilla, Centanni, Marco, Fabiani, Cristina, Rago, Rocco, Schiavi, Michele Carlo, Palazzetti, Pierluigi, D’Armiento, Eleonora, Cantisani, Vito, Sorrenti, Salvatore, Ulisse, Salvatore

“…Adequate iodine intake is of crucial importance in pregnancy to meet the thyroid hormone needs of both mother and fetus. In the present study, undertaken as a…”
Get full text

Dystonia: Sparse Synapses for D2 Receptors in Striatum of a DYT1 Knock-out Mouse Model by D'Angelo, Vincenza, Paldino, Emanuela, Cardarelli, Silvia, Sorge, Roberto, Fusco, Francesca Romana, Biagioni, Stefano, Mercuri, Nicola Biagio, Giorgi, Mauro, Sancesario, Giuseppe

“…Dystonia pathophysiology has been partly linked to downregulation and dysfunction ofdopamine D2 receptors in striatum. We aimed to investigate the possible…”
Get full text

Patellar Fracture Fixation Using Suture Tape Cerclage by Monaco, Edoardo, Bruni, Giorgio, Daggett, Matt, Saithna, Adnan, Cardarelli, Silvia, Proietti, Lorenzo, Ferretti, Andrea

“…Transverse patellar fractures are a relatively common injury and typically require surgical fixation. An adequate restoration of patella integrity is essential…”
Get full text

Fixation of patella fractures with metallic implants is associated with a significantly higher risk of complications and re-operations than non-metallic implants: a systematic review and meta-analysis by Edoardo, Monaco, Andrea, Del Duca, Silvia, Cardarelli, Fabio, Marzilli, Alessandro, Carrozzo, Adnan, Saithna, Andrea, Ferretti

“…Purpose The use of metallic implants for the treatment of patella fractures often involves complications related to the hardware. As a result, there has been a…”
Get full text

Response to “Letter to the editor on “Fixation of patella fractures with metallic implants is associated with a significantly higher risk of complications and re-operations than non-metallic implants: a systematic review and meta-analysis””: By Gao Y, Wu H. (2023) Int Orthop.;47(7):1879–1880. doi: 10.1007/s00264-023-05815-9 by Monaco, Edoardo, Del Duca, Andrea, Cardarelli, Silvia, Marzilli, Fabio, Carrozzo, Alessandro, Saithna, Adnan, Ferretti, Andrea

Get full text

Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma by Massimi, Mara, Ragusa, Federica, Cardarelli, Silvia, Giorgi, Mauro

“…Hepatocellular carcinoma (HCC) is a major healthcare problem worldwide, representing one of the leading causes of cancer mortality. Since there are currently…”
Get full text

Anterior Cruciate Ligament Revision Plus Lateral Extra-Articular Procedure Results in Superior Stability and Lower Failure Rates Than Does Isolated Anterior Cruciate Ligament Revision but Shows No Difference in Patient-Reported Outcomes or Return to Sports by Saithna, Adnan, Monaco, Edoardo, Carrozzo, Alessandro, Marzilli, Fabio, Cardarelli, Silvia, Lagusis, Benson, Rossi, Giorgio, Dutra Vieira, Thais, Ferretti, Andrea, Sonnery-Cottet, Bertrand

“…To determine whether comparative clinical studies demonstrate significant advantages of revision anterior cruciate ligament reconstruction (RACLR) combined…”
Get full text

Metabolic role of cGMP in S. cerevisiae: the murine phosphodiesterase-5 activity affects yeast cell proliferation by altering the cAMP/cGMP equilibrium by Cardarelli, Silvia, Giorgi, Mauro, Poiana, Giancarlo, Biagioni, Stefano, Saliola, Michele

“…In higher eukaryotes, cAMP and cGMP are signal molecules of major transduction pathways while phosphodiesterases (PDE) are a superfamily of cAMP/cGMP…”
Get full text