Understanding the Angiogenic Characteristics of Clinical-Grade Mesenchymal Stromal Cells Isolated from Human Umbilical Cord

Understanding the Angiogenic Characteristics of Clinical-Grade Mesenchymal Stromal Cells Isolated from Human Umbilical Cord

Addressing the challenges in managing ischemic tissue repair and remodelling remains a prominent clinical concern. Current research is heavily concentrated on identifying innovative cell-based therapies with the potential to enhance revascularization in patients affected by these diseases. We have p...

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Bibliographic Details
Published in:Stem cell reviews and reports Vol. 20; no. 5; p. 1353
Main Authors: Carcopino, Charlotte, Rossi, Elisa, Mebarki, Miryam, El Hamaoui, Divina, Gaussem, Pascale, Larghero, Jérôme, Smadja, David M, Cras, Audrey
Format: Journal Article
Language:English
Published: United States 01-07-2024
Subjects:
Cell Differentiation
Cell Movement
Cell Proliferation
Cells, Cultured
Endothelial Cells - cytology
Endothelial Cells - metabolism
Human Umbilical Vein Endothelial Cells - cytology
Human Umbilical Vein Endothelial Cells - metabolism
Humans
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - metabolism
Neovascularization, Physiologic
Umbilical Cord - cytology
Mesenchymal stromal cells
Angiogenesis
Good manufacturing practice
Umbilical cord
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Summary:Addressing the challenges in managing ischemic tissue repair and remodelling remains a prominent clinical concern. Current research is heavily concentrated on identifying innovative cell-based therapies with the potential to enhance revascularization in patients affected by these diseases. We have previously developed and validated a manufacturing process for human umbilical cord mesenchymal stromal cells (UC-MSCs)-based cell therapy medicinal product, according to Good Manufacturing Practices. In this study, we demonstrate that these UC-MSCs enhance the proliferation and migration of endothelial cells and the formation of capillary structures. Moreover, UC-MSCs and endothelial cells interact, allowing UC-MSCs to acquire a perivascular cell phenotype and consequently provide direct support to the newly formed vascular network. This characterization of the proangiogenic properties of this UC-MSCs based-cell therapy medicinal product is an essential step for its therapeutic assessment in the clinical context of vascular regeneration.
ISSN:2629-3277
DOI:10.1007/s12015-024-10712-8