Search Results - "Carbone, Daniela"
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Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections
Published in ChemMedChem (08-01-2021)“…Methicillin‐resistant Staphylococcus aureus (MRSA) has emerged as one of the leading causes of persistent human infections. This pathogen is widespread and is…”
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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
Published in Molecular cancer (18-08-2023)“…The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and…”
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Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy
Published in International journal of molecular sciences (01-03-2023)“…Infectious diseases caused by antimicrobial-resistant strains have become a serious threat to global health, with a high social and economic impact…”
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Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New?
Published in Current medicinal chemistry (01-01-2023)Get more information
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Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
Published in Molecules (Basel, Switzerland) (27-12-2020)“…Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial…”
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A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells
Published in Molecules (Basel, Switzerland) (21-12-2021)“…Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years,…”
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Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma
Published in International journal of molecular sciences (01-02-2023)“…Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly involved in altered cancer cell metabolism, resulting in cancer…”
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3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma
Published in Molecules (Basel, Switzerland) (14-01-2020)“…A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and screened for their in vitro antiproliferative activity on a panel…”
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Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development
Published in Molecules (Basel, Switzerland) (01-09-2023)“…The marine environment is an excellent source of molecules that have a wide structural diversity and a variety of biological activities. Many marine natural…”
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10
HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells
Published in Nature communications (10-08-2023)“…The mechanism of human immunodeficiency virus 1 (HIV-1) nuclear entry, required for productive infection, is not fully understood. Here, we report that in HeLa…”
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Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma
Published in Marine drugs (04-05-2023)“…Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer, characterized by late prognosis and drug resistance. Among the main…”
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1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1
Published in Marine drugs (01-07-2023)“…A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,3,4-oxadiazole or 1,3,4-thiadiazole moiety,…”
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Novel [1,3,4]Thiadiazole[3,2- a ]pyrimidin-5-ones as Promising Biofilm Dispersal Agents against Relevant Gram-Positive and Gram-Negative Pathogens
Published in Marine drugs (01-03-2024)“…Biofilm-associated infections pose significant challenges in healthcare settings due to their resistance to conventional antimicrobial therapies. In the last…”
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Nanoparticle-Imprinted Silica Gel for the Size-Selective Capture of Silver Ultrafine Nanoparticles from Water
Published in Molecules (Basel, Switzerland) (11-05-2023)“…A synthetic approach has been developed to prepare silica gel monoliths that embed well separated silver or gold spherical nanoparticles (NP), with diameters…”
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Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position
Published in Molecules (Basel, Switzerland) (01-11-2022)“…Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their…”
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Study of Polymer Particles Suspensions for Electrophoretic Deposition
Published in The journal of physical chemistry. B (14-02-2013)“…Recently a great interest has been expressed in electrophoretic deposition (EPD) of polymers, both as particles and as chains. It is generally accepted that…”
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CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin
Published in iScience (25-06-2021)“…Limited therapeutic options are available for advanced colorectal cancer (CRC). Herein, we report that exposure to a neo-synthetic bis(indolyl)thiazole…”
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A Combination of Polymethoxyflavones from Citrus sinensis and Prenylflavonoids from Humulus lupulus Counteracts IL-1β-Induced Differentiated Caco-2 Cells Dysfunction via a Modulation of NF-κB/Nrf2 Activation
Published in Antioxidants (16-08-2023)“…We here investigated the anti-inflammatory activity of a polymethoxylated flavone-containing fraction (PMFF) from Citrus sinensis and of a…”
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Reseña del libro de Daniel Del Percio, La historia y un instante
Published in Journal de ciencias sociales (29-10-2023)“…Daniel Del Percio en su primera novela, La historia y un instante, nos invita a emprender un viaje por una ucronía que inicia con la modificación de un…”
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Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance
Published in Journal of medicinal chemistry (13-08-2020)“…Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized as nuclei of great value for obtaining molecules with various…”
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