Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials

Mentha piperita L. essential oil (EO) is employed for external use as antipruritic, astringent, rubefacient and antiseptic. Several studies demonstrated its significant antiviral, antifungal and antibacterial properties. The aim of this work is the study of the synergistic effects of M. piperita EO...

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Bibliographic Details
Published in:	PloS one Vol. 13; no. 8; p. e0200902
Main Authors:	Rosato, Antonio, Carocci, Alessia, Catalano, Alessia, Clodoveo, Maria Lisa, Franchini, Carlo, Corbo, Filomena, Carbonara, Giuseppe Gerardo, Carrieri, Antonio, Fracchiolla, Giuseppe
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-08-2018 Public Library of Science (PLoS)
Subjects:	Aminoglycosides Analysis Antibiotics Antifungal agents Antimicrobial agents Antiviral activity Antiviral agents Bacteria Bacterial infections Biology and Life Sciences Chromatography Cosmetics Drug development Drug resistance Essential oils Fungi Fungicides Gentamicin Gram-negative bacteria Laboratories Lamiaceae Mass spectrometry Medicine and Health Sciences Mentha piperita Methods Microbial drug resistance Multidrug resistance Oils & fats Peppermint Pharmacy Research and Analysis Methods Scientific imaging Synergistic effect Yeast United States > US Italy
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Summary:	Mentha piperita L. essential oil (EO) is employed for external use as antipruritic, astringent, rubefacient and antiseptic. Several studies demonstrated its significant antiviral, antifungal and antibacterial properties. The aim of this work is the study of the synergistic effects of M. piperita EO with antibacterials and antifungals that are widely available and currently prescribed in therapies against infections. The observed strong synergy may constitute a potential new approach to counter the increasing phenomenon of multidrug resistant bacteria and fungi. In vitro efficacy of the association M. piperita EO/drugs was evaluated against a large panel of Gram-positive and Gram-negative bacteria and yeast strains. The antimicrobial effects were studied by checkerboard microdilution method. The synergistic effect of M. piperita EO with gentamicin resulted in a strong growth inhibition for all the bacterial species under study. The synergistic effect observed for M. piperita EO and antifungals was less pronounced.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0200902