Search Results - "Carbo, Adria"
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Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis
Published in PloS one (21-02-2012)“…Inflammatory bowel disease (IBD) therapies are modestly successful and associated with significant side effects. Thus, the investigation of novel approaches to…”
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2
Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity
Published in PLoS computational biology (01-04-2013)“…Differentiation of CD4+ T cells into effector or regulatory phenotypes is tightly controlled by the cytokine milieu, complex intracellular signaling networks…”
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3
Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection
Published in PloS one (05-09-2013)“…T helper (Th) cells play a major role in the immune response and pathology at the gastric mucosa during Helicobacter pylori infection. There is a limited…”
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4
Modeling-Enabled Characterization of Novel NLRX1 Ligands
Published in PloS one (29-12-2015)“…Nucleotide-binding domain and leucine-rich repeat containing (NLR) family are intracellular sentinels of cytosolic homeostasis that orchestrate immune and…”
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5
Helicobacter pylori Infection in a Pig Model Is Dominated by Th1 and Cytotoxic CD8+ T Cell Responses
Published in Infection and Immunity (01-10-2013)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to Helicobacter pylori Infection
Published in PloS one (01-09-2015)“…Agent-based models (ABM) are widely used to study immune systems, providing a procedural and interactive view of the underlying system. The interaction of…”
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7
Abscisic Acid: A Novel Nutraceutical for Glycemic Control
Published in Frontiers in nutrition (Lausanne) (13-06-2017)“…Abscisic acid is naturally present in fruits and vegetables, and it plays an important role in managing glucose homeostasis in humans. According to the latest…”
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8
Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2
Published in PloS one (11-04-2012)“…Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the eukaryotic lanthionine synthetase component C-Like protein family involved in…”
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Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection
Published in mBio (22-07-2014)“…The development of gastritis during Helicobacter pylori infection is dependent on an activated adaptive immune response orchestrated by T helper (Th) cells…”
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10
Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficile
Published in PloS one (11-10-2012)“…Clostridium difficile is an anaerobic bacterium that has re-emerged as a facultative pathogen and can cause nosocomial diarrhea, colitis or even death…”
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11
Systematic reverse engineering of network topologies: a case study of resettable bistable cellular responses
Published in PloS one (29-08-2014)“…A focused theme in systems biology is to uncover design principles of biological networks, that is, how specific network structures yield specific systems…”
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12
Helicobacter pylori colonization ameliorates glucose homeostasis in mice through a PPAR γ-dependent mechanism
Published in PloS one (15-11-2012)“…There is an inverse secular trend between the incidence of obesity and gastric colonization with Helicobacter pylori, a bacterium that can affect the secretion…”
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13
Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease
Published in PloS one (20-04-2010)“…Peroxisome proliferator-activated receptors are nuclear receptors highly expressed in intestinal epithelial cells (IEC) and immune cells within the gut mucosa…”
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14
An N,N‑Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C‑Like 2‑Based Therapeutic for Inflammatory Bowel Disease
Published in Journal of medicinal chemistry (23-11-2016)“…Lanthionine synthetase C-like 2 (LANCL2), a novel therapeutic target for inflammatory and autoimmune diseases and diabetes, exerts anti-inflammatory and…”
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15
Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis
Published in Gut microbes (02-01-2016)“…Helicobacter pylori is the dominant member of the gastric microbiota in over half of the human population of which 5-15% develop gastritis or gastric…”
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16
Multiscale modeling of mucosal immune responses
Published in BMC bioinformatics (25-08-2015)“…Computational techniques are becoming increasingly powerful and modeling tools for biological systems are of greater needs. Biological systems are inherently…”
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Abscisic Acid Regulates Inflammation via Ligand-binding Domain-independent Activation of Peroxisome Proliferator-activated Receptor γ
Published in The Journal of biological chemistry (28-01-2011)“…Abscisic acid (ABA) has shown efficacy in the treatment of diabetes and inflammation; however, its molecular targets and the mechanisms of action underlying…”
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Su1911 - BT-11: A Novel Lanthionine Synthetase C-Like 2-Based Oral Therapeutic for Inflammatory Bowel Disease
Published in Gastroenterology (New York, N.Y. 1943) (01-04-2017)Get full text
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19
BT-11: A Novel Lanthionine Synthetase C-Like 2-Based Oral Therapeutic for Inflammatory Bowel Disease
Published in Gastroenterology (New York, N.Y. 1943) (01-04-2017)Get full text
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20
Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells
Published in Cell chemical biology (16-11-2023)“…TruAB Discovery is an approach that integrates cellular immunology, high-throughput immunosequencing, bioinformatics, and computational biology in order to…”
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