Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2

The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been veri...

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Published in:	Viruses Vol. 14; no. 2; p. 418
Main Authors:	Clayton, Emily, Ackerley, Jacob, Aelmans, Marianne, Ali, Noor, Ashcroft, Zoe, Ashton, Clara, Barker, Robert, Budryte, Vakare, Burrows, Callum, Cai, Shanshan, Callaghan, Alex, Carberry, Jake, Chatwin, Rebecca, Davies, Isabella, Farlow, Chloe, Gamblin, Samuel, Iacobut, Aida, Lambe, Adam, Lynch, Francesca, Mihalache, Diana, Mokbel, Amani, Potamsetty, Santosh, Qadir, Zara, Soden, Jack, Sun, Xiaohan, Vasile, Alexandru, Wheeler, Otto, Rohaim, Mohammed A, Munir, Muhammad
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 17-02-2022 MDPI
Subjects:	ACE2 Angiotensin Angiotensin-converting enzyme 2 Animal models Animals Coronaviruses COVID-19 COVID-19 - epidemiology COVID-19 - transmission eradication Host Specificity Humans Middle East respiratory syndrome Mutation Peptidyl-dipeptidase A Phylogeny Receptors, Virus Review SARS-CoV-2 SARS-CoV-2 - chemistry SARS-CoV-2 - classification SARS-CoV-2 - genetics SARS-CoV-2 - pathogenicity Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - genetics Spike protein transmission Viruses Zoonoses Zoonoses - epidemiology Zoonoses - transmission Zoonoses - virology zoonotic ACE2 SARS-CoV-2 transmission zoonotic eradication
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Summary:	The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v14020418