Search Results - "Caramelo, Julio J."

A sweet code for glycoprotein folding by Caramelo, Julio J., Parodi, Armando J.

“…Glycoprotein synthesis is initiated in the endoplasmic reticulum (ER) lumen upon transfer of a glycan (Glc3Man9GlcNAc2) from a lipid derivative to Asn residues…”
Get full text

Getting In and Out from Calnexin/Calreticulin Cycles by Caramelo, Julio J., Parodi, Armando J.

Get full text

UDP-GlC:glycoprotein glucosyltransferase-glucosidase II, the ying-yang of the ER quality control by D’Alessio, Cecilia, Caramelo, Julio J., Parodi, Armando J.

“…The N-glycan-dependent quality control of glycoprotein folding prevents endoplasmic to Golgi exit of folding intermediates, irreparably misfolded glycoproteins…”
Get full text

Conformational plasticity of the intrinsically disordered protein ASR1 modulates its function as a drought stress-responsive gene by Wetzler, Diana E, Fuchs Wightman, Federico, Bucci, Hernan A, Rinaldi, Jimena, Caramelo, Julio J, Iusem, Norberto D, Ricardi, Martiniano M

“…Plants in arid zones are constantly exposed to drought stress. The ASR protein family (Abscisic, Stress, Ripening) -a subgroup of the late embryogenesis…”
Get full text

Alternative Splicing of G9a Regulates Neuronal Differentiation by Fiszbein, Ana, Giono, Luciana E., Quaglino, Ana, Berardino, Bruno G., Sigaut, Lorena, von Bilderling, Catalina, Schor, Ignacio E., Steinberg, Juliana H. Enriqué, Rossi, Mario, Pietrasanta, Lía I., Caramelo, Julio J., Srebrow, Anabella, Kornblihtt, Alberto R.

“…Chromatin modifications are critical for the establishment and maintenance of differentiation programs. G9a, the enzyme responsible for histone H3 lysine 9…”
Get full text

Uncoupling cis-Acting RNA Elements from Coding Sequences Revealed a Requirement of the N-Terminal Region of Dengue Virus Capsid Protein in Virus Particle Formation by SAMSA, Marcelo M, MONDOTTE, Juan A, CARAMELO, Julio J, GAMARNIK, Andrea V

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Structural basis of redox-dependent modulation of galectin-1 dynamics and function by Guardia, Carlos M, Caramelo, Julio J, Trujillo, Madia, Méndez-Huergo, Santiago P, Radi, Rafael, Estrin, Darío A, Rabinovich, Gabriel A

“…Galectin-1 (Gal-1), a member of a family of multifunctional lectins, plays key roles in diverse biological processes including cell signaling,…”
Get full text

N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins by Medus, Máximo Lopez, Gomez, Gabriela E., Zacchi, Lucía F., Couto, Paula M., Labriola, Carlos A., Labanda, María S., Bielsa, Rodrigo Corti, Clérico, Eugenia M., Schulz, Benjamin L., Caramelo, Julio J.

“…Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N -glycosylated in the lumen of the endoplasmic…”
Get full text

How sugars convey information on protein conformation in the endoplasmic reticulum by Caramelo, Julio J., Parodi, Armando J.

“…The N-glycan-dependent quality control of glycoprotein folding prevents endoplasmic reticulum to Golgi exit of folding intermediates, irreparably misfolded…”
Get full text

Structural coalescence underlies the aggregation propensity of a β-barrel protein motif by Angelani, Carla R, Caramelo, Julio J, Curto, Lucrecia M, Delfino, José M

“…A clear understanding of the structural foundations underlying protein aggregation is an elusive goal of central biomedical importance. A step toward this aim…”
Get full text

Protein Fibrillation Lag Times During Kinetic Inhibition by Pagano, Rodrigo S., López Medus, Máximo, Gómez, Gabriela E., Couto, Paula M., Labanda, María S., Landolfo, Lucas, D’Alessio, Cecilia, Caramelo, Julio J.

“…Protein aggregation is linked to more than 30 human pathologies, including Alzheimer’s and Parkinson’s diseases. Since small oligomers that form at the…”
Get full text

Overcoming Limited Access to Virus Infection Rapid Testing: Development of a Lateral Flow Test for SARS-CoV-2 with Locally Available Resources by Peri Ibáñez, Estefanía S, Mazzeo, Agostina, Silva, Carolina, Juncos, Maria Juliana, Costa Navarro, Guadalupe S, Pallarés, Horacio M, Wolos, Virginia J, Fiszman, Gabriel L, Mundo, Silvia L, Caramelo, Julio J, Yanovsky, Marcelo J, Fingermann, Matías, Castello, Alejandro A, Gamarnik, Andrea V, Peinetti, Ana S, Capdevila, Daiana A

“…The COVID-19 pandemic highlighted testing inequities in developing countries. Lack of lateral flow test (LFT) manufacturing capacity was a major COVID-19…”
Get full text

Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: Glycoprotein glucosyltransferase (UGGT) by Prados, María B., Caramelo, Julio J., Miranda, Silvia E.

“…UDP-Glucose:glycoprotein glucosyltransferase (UGGT) is a central component of the endoplasmic reticulum (ER) glycoprotein-folding quality control system, which…”
Get full text

Truncation of a β-Barrel Scaffold Dissociates Intrinsic Stability from Its Propensity to Aggregation by Curto, Lucrecia M., Angelani, Carla R., Caramelo, Julio J., Delfino, José M.

“…Δ98Δ is a functional all-β sheet variant of intestinal fatty acid binding protein (IFABP) that was generated by controlled proteolysis. This framework is…”
Get full text

UDP-Glc:glycoprotein Glucosyltransferase Recognizes Structured and Solvent Accessible Hydrophobic Patches in Molten Globule-like Folding Intermediates by Caramelo, Julio J., Castro, Olga A., Alonso, Leonardo G., de Prat-Gay, Gonzalo, Parodi, Armando J.

“…Protein folding in the cell involves the action of different molecular chaperones and folding-facilitating enzymes. In the endoplasmic reticulum (ER), the…”
Get full text

The Endoplasmic Reticulum Glucosyltransferase Recognizes Nearly Native Glycoprotein Folding Intermediates by Caramelo, Julio J, Castro, Olga A, de Prat-Gay, Gonzalo, Parodi, Armando J

“…The UDP-Glc:glycoprotein glucosyltransferase (GT), a key player in the endoplasmic reticulum (ER) quality control of glycoprotein folding, only glucosylates…”
Get full text

Structure of Calreticulin C-terminal Domain Is Modulated by Physiological Variations of Calcium Concentration by Giraldo, Ana María Villamil, Medus, Máximo Lopez, Lebrero, Mariano Gonzalez, Pagano, Rodrigo S, Labriola, Carlos A, Landolfo, Lucas, Delfino, José M, Parodi, Armando J, Caramelo, Julio J

“…Calreticulin is an abundant endoplasmic reticulum resident protein that fulfills at least two basic functions. Firstly, due to its ability to bind…”
Get full text

Endoplasmic reticulum calcium regulates the retrotranslocation of Trypanosoma cruzi calreticulin to the cytosol by Labriola, Carlos A, Conte, Ianina L, López Medus, Máximo, Parodi, Armando J, Caramelo, Julio J

“…For most secretory pathway proteins, crossing the endoplasmic reticulum (ER) membrane is an irreversible process. However, in some cases this flow can be…”
Get full text

Identification and Characterization of a High-Affinity Choline Uptake System of Brucella abortus by Herrmann, Claudia K, Bukata, Lucas, Melli, Luciano, Marchesini, M. Ines, Caramelo, Julio J, Comerci, Diego J

“…Phosphatidylcholine (PC), a common phospholipid of the eukaryotic cell membrane, is present in the cell envelope of the intracellular pathogen Brucella…”
Get full text

Correction for Samsa et al., "Uncoupling cis -Acting RNA Elements from Coding Sequences Revealed a Requirement of the N-Terminal Region of Dengue Virus Capsid Protein in Virus Particle Formation" by Samsa, Marcelo M, Mondotte, Juan A, Caramelo, Julio J, Gamarnik, Andrea V

Get full text