Effect of melatonin on otoprotection in rodents: a systematic review with meta-analysis

•Melatonin provide protection against the ototoxic effects at 5, 6 and 8 kHz.•The available paper’s methodology did not meet the rigor for replicability.•New studies that establish a dose-effect curve of melatonin should be encouraged. To determinate the otoprotective efficacy of melatonin.in experi...

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Published in:	Brazilian journal of otorhinolaryngology Vol. 89; no. 5; p. 101288
Main Authors:	Assumpção, Natália Lombardi, Araújo, Juliana Gusmão de, Serra, Lucieny Silva Martins, Ribeiro, Vanessa Veis, Sampaio, Maria Luiza Queiroz, Caram, Andressa Alves, Sampaio, André Luiz Lopes
Format:	Journal Article
Language:	English
Published:	Brazil Elsevier España S.L.U 01-09-2023 Elsevier Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
Subjects:	Melatonin Otoprotection OTORHINOLARYNGOLOGY Ototoxic agents Review Rodents Ototoxic agents Otoprotection Melatonin Rodents
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Summary:	•Melatonin provide protection against the ototoxic effects at 5, 6 and 8 kHz.•The available paper’s methodology did not meet the rigor for replicability.•New studies that establish a dose-effect curve of melatonin should be encouraged. To determinate the otoprotective efficacy of melatonin.in experimental models of rodents through a systematic review of the literature. Altogether, 154 articles were found in four databases. The PICOS strategy (Population, Intervention, Comparison, and Outcome) was used to define the eligibility criteria. Studies that met the inclusion criteria for the second step were included in a qualitative synthesis. Each study type was analyzed with the CAMARADES quality of assessment’s checklist and the SYRCLE RoBS risk of bias. Seven articles were selected, and four were included in the meta-analysis. It was possible to obtain seven outcomes according to the standard auditory frequencies presented among the studies, considering a minimum of three standard frequencies. The outcomes analyzed were for the frequencies of 1500, 2000, 3000, 4000, 5000, 6000, and 8000 Hz. Melatonin can provide protection against the ototoxic effects of cisplatin and aminoglycosides at 5000 Hz, 6000 Hz, and 8000 Hz, thereby minimizing the reduction in Otoacustic Emissions (OAE) amplitude. The same effect was not observed in the lower frequencies. Despite the limited number of studies that were evaluated, the results appeared consistent in higher frequencies. However, the methodology of the available studies did not meet the necessary methodological rigor that promotes the safe replicability of these studies.
Bibliography:	SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Review-1 ObjectType-Article-3 ObjectType-Undefined-4
ISSN:	1808-8694 1808-8686 1808-8686
DOI:	10.1016/j.bjorl.2023.101288