Search Results - "Carabeo, Rey A"

Dynamin-dependent entry of Chlamydia trachomatis is sequentially regulated by the effectors TarP and TmeA by Romero, Matthew D., Carabeo, Rey A.

“…Chlamydia invasion of epithelial cells is a pathogen-driven process involving two functionally distinct effectors – TarP and TmeA. They collaborate to promote…”
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The role of infected epithelial cells in Chlamydia -associated fibrosis by Caven, Liam T, Carabeo, Rey A

“…Ocular, genital, and anogenital infection by the obligate intracellular pathogen have been consistently associated with scar-forming sequelae. In cases of…”
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The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis by Pokorzynski, Nick D., Hatch, Nathan D., Ouellette, Scot P., Carabeo, Rey A.

“…The trp operon of Chlamydia trachomatis is organized differently from other model bacteria. It contains trpR , an intergenic region (IGR), and the biosynthetic…”
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Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis by Pokorzynski, Nick D, Alla, Monisha R, Carabeo, Rey A

“…Persistence, a viable but non-replicating growth state, has been implicated in diseases caused by Chlamydia trachomatis. Starvation of distinct nutrients…”
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Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the type II interferon response of epithelial cells by Fontanilla, Francis L, Ibana, Joyce A, Carabeo, Rey A, Brinkworth, Amanda J

“…has adapted to subvert signaling in epithelial cells to ensure successful intracellular development. Interferon-γ (IFNγ) produced by recruited lymphocytes…”
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Chlamydia trachomatis induces the transcriptional activity of host YAP in a Hippo-independent fashion by Caven, Liam T, Brinkworth, Amanda J, Carabeo, Rey A

“…The obligate intracellular pathogen Chlamydia trachomatis is the causative agent of the most common bacterial sexually transmitted disease worldwide. While the…”
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Alternatively Activated Macrophages Are Host Cells for Chlamydia trachomatis and Reverse Anti-chlamydial Classically Activated Macrophages by Tietzel, Illya, Quayle, Alison J, Carabeo, Rey A

“…The obligate intracellular pathogen (Ctr) is the causative agent of the most common form of sexually transmitted disease in the United States. Genital…”
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Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma by Tietzel, Illya, El-Haibi, Christelle, Carabeo, Rey A

“…Chlamydiae are obligate intracellular pathogens that are sensitive to pro-inflammatory cytokine interferon-gamma. IFN-gamma-inducible murine p47 GTPases have…”
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Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia by Pokorzynski, Nick D, Thompson, Christopher C, Carabeo, Rey A

“…The obligate intracellular pathogen , along with its close species relatives, is known to be strictly dependent upon the availability of iron. Deprivation of…”
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The Chlamydia Effector TarP Mimics the Mammalian Leucine-Aspartic Acid Motif of Paxillin to Subvert the Focal Adhesion Kinase during Invasion by Thwaites, Tristan, Nogueira, Ana T., Campeotto, Ivan, Silva, Ana P., Grieshaber, Scott S., Carabeo, Rey A.

“…Host cell signal transduction pathways are often targets of bacterial pathogens, especially during the process of invasion when robust actin remodeling is…”
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Characterization of the Growth of Chlamydia trachomatis in In Vitro -Generated Stratified Epithelium by Nogueira, Ana T, Braun, Kristin M, Carabeo, Rey A

“…infection targets the mucosal epithelium, where squamous and columnar epithelia can be found. Research on -epithelia interaction has predominantly focused on…”
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Chlamydia species-dependent differences in the growth requirement for lysosomes by Ouellette, Scot P, Dorsey, Frank C, Moshiach, Simon, Cleveland, John L, Carabeo, Rey A

“…Genome reduction is a hallmark of obligate intracellular pathogens such as Chlamydia, where adaptation to intracellular growth has resulted in the elimination…”
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Metabolic model guided CRISPRi identifies a central role for phosphoglycerate mutase in Chlamydia trachomatis persistence by Chowdhury, Niaz Bahar, Pokorzynski, Nick, Rucks, Elizabeth A, Ouellette, Scot P, Carabeo, Rey A, Saha, Rajib

“…Upon nutrient starvation, serovar L2 (CTL) shifts from its normal growth to a non-replicating form, termed persistence. It is unclear if persistence reflects…”
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Chlamydial entry involves TARP binding of guanine nucleotide exchange factors by Lane, B Josh, Mutchler, Charla, Al Khodor, Souhaila, Grieshaber, Scott S, Carabeo, Rey A

“…Chlamydia trachomatis attachment to cells induces the secretion of the elementary body-associated protein TARP (Translocated Actin Recruiting Protein). TARP…”
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Genomewide Transcriptional Responses of Iron-Starved Chlamydia trachomatis Reveal Prioritization of Metabolic Precursor Synthesis over Protein Translation by Brinkworth, Amanda J, Wildung, Mark R, Carabeo, Rey A

“…Iron is essential for growth and development of . Its long-term starvation in cultured mammalian cells leads to production of aberrant noninfectious chlamydial…”
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Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane by Thwaites, Tristan R, Pedrosa, Antonio T, Peacock, Thomas P, Carabeo, Rey A

“…The mammalian protein vinculin is often a target of bacterial pathogens to subvert locally host cell actin dynamics. In Chlamydia infection, vinculin has been…”
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Rac interacts with Abi‐1 and WAVE2 to promote an Arp2/3‐dependent actin recruitment during chlamydial invasion by Carabeo, Rey A., Dooley, Cheryl A., Grieshaber, Scott S., Hackstadt, Ted

“…Summary Chlamydiae are Gram‐negative obligate intracellular pathogens to which access to an intracellular environment is fundamental to their development…”
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Cleavage of a putative metal permease in Chlamydia trachomatis yields an iron-dependent transcriptional repressor by Thompson, Christopher C, Nicod, Sophie S, Malcolm, Denise S, Grieshaber, Scott S, Carabeo, Rey A

“…The regulation of iron homeostasis is essential for most organisms, because iron is required for a variety of conserved biochemical processes, yet can be toxic…”
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Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis by Caven, Liam, Carabeo, Rey A

“…The actin cytoskeleton is crucially important to maintenance of the cellular structure, cell motility, and endocytosis. Accordingly, bacterial pathogens often…”
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Distinct roles of the Chlamydia trachomatis effectors TarP and TmeA in the regulation of formin and Arp2/3 during entry by Romero, Matthew D, Carabeo, Rey A

“…The obligate intracellular pathogen Chlamydia trachomatis manipulates the host actin cytoskeleton to assemble actin-rich structures that drive pathogen entry…”
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