Differential effect of heterocyclic d -ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression

Differential effect of heterocyclic d -ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression

Abstract New d -ribofuranoside derivatives containing two five membered heterocycles, isoxazole and triazole or two triazole rings, were synthesized. The final products as well as the synthetic precursors were physically and spectroscopically characterized. These new diheterocyclic derivatives toget...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy Vol. 68; no. 7; pp. 847 - 854
Main Authors: Gueron, Geraldine, Avanzo, Romina E, Schuster, Federico, Carabelos, Maria N, Vazquez, Elba, Fascio, Mirta L, D’Accorso, Norma B
Format: Journal Article
Language:English
Published: France Elsevier Masson SAS 01-09-2014
Subjects:
Alkenes - pharmacology
Antineoplastic Agents - pharmacology
Carbohydrates
Cell Line, Tumor
Cell Survival - drug effects
d-Ribose
G1 Phase Cell Cycle Checkpoints - drug effects
Humans
Internal Medicine
Isoxazole
Isoxazoles - pharmacology
Male
Medical Education
PC3 cell line
Prostate cancer
Prostatic Neoplasms - drug therapy
Resting Phase, Cell Cycle - drug effects
Triazole
Triazoles - pharmacology
Isoxazole
Triazole
Prostate cancer
d-Ribose
PC3 cell line
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Summary:Abstract New d -ribofuranoside derivatives containing two five membered heterocycles, isoxazole and triazole or two triazole rings, were synthesized. The final products as well as the synthetic precursors were physically and spectroscopically characterized. These new diheterocyclic derivatives together with other d -riboside compounds were assessed for their impact on PC3 cell line viability. We found that exposure of prostate cancer cells to some of these compounds caused a significant inhibition of cell growth and a G0 /G1 cell cycle arrest, which was concomitant with alterations in the expression of proteins involved in cell cycle progression. Furthermore, the inhibitory activity was improved in di-heterocycles when the carbohydrate moiety was protected with a cyclopentylidene group compared to the isopropylidene analogues.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2014.08.010