Search Results - "Carabateas, Philip M."

Antirhinoviral activity of heterocyclic analogs of Win 54954 by Bailey, Thomas R, Diana, Guy D, Kowalczyk, Paul J, Akullian, Vahan, Eissenstat, Michael A, Cutcliffe, David, Mallamo, John P, Carabateas, Philip M, Pevear, Daniel C

“…A variety of heterocyclic analogs of Win 54954 have been synthesized and tested in vitro against human rhinovirus type 14 (HRV-14) in a plaque reduction assay…”
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Synthesis of .alpha.-substituted 1,2-benzenedimethanamines by Johnson, Robert E, Hane, Jeffrey T, Schlegel, Donald C, Perni, Robert B, Herrmann, John L, Opalka, Chester J, Carabateas, Philip M, Ackerman, James H, Swestock, John

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Synthesis and Structure-Activity Relationships of 6-Heterocyclic-Substituted Purines as Inactivation Modifiers of Cardiac Sodium Channels by Estep, Kimberly G, Josef, Kurt A, Bacon, Edward R, Carabateas, Philip M, Rumney, Squire, Pilling, Garry M, Krafte, Douglas S, Volberg, Walter A, Dillon, Kathleen, Dugrenier, Nancy, Briggs, G. Maurice, Canniff, Paul C, Gorczyca, William P, Stankus, Gerald P, Ezrin, Alan M

“…Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in…”
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Orally Bioavailable Benzisothiazolone Inhibitors of Human Leukocyte Elastase by Hlasta, Dennis J, Subramanyam, Chakrapani, Bell, Malcolm R, Carabateas, Philip M, Court, John J, Desai, Ranjit C, Drozd, Marion L, Eickhoff, W. Mark, Ferguson, Edward W, Gordon, Robert J, Dunlap, Richard P, Franke, Catherine A, Mura, Albert J, Rowlands, Anne, Johnson, Judith A, Kumar, Virendra, Maycock, Alan L, Mueller, Karl R, Pagani, Edward D, Robinson, David T, Saindane, Manohar T, Silver, Paul J, Subramanian, Sandhya

“…Human leukocyte elastase (HLE) has been proposed as a primary mediator of pulmonary emphysema and other inflammatory airway diseases. HLE is capable of…”
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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents by Reuman, Michael, Daum, Sol J, Singh, Baldev, Wentland, Mark P, Perni, Robert B, Pennock, Patrick, Carabateas, Philip M, Gruett, Monte D, Saindane, Manohar T, Dorff, Peter H, Coughlin, Susan A, Sedlock, David M, Rake, James B, Lesher, George Y

“…The palladium-catalyzed coupling of 3- and 4-(trialkylstannyl)pyridines with 7-bromo or 7-chloro 1-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylates has…”
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3-Quinolinecarboxamides. A series of novel orally-active antiherpetic agents by Wentland, Mark P, Perni, Robert B, Dorff, Peter H, Brundage, R. Pauline, Castaldi, Michael J, Bailey, Thomas R, Carabateas, Philip M, Bacon, Edward R, Young, Dorothy C

“…A series of novel 3-quinolinecarboxamides that are structurally similar to the quinolone class of antibacterial agents possess excellent antiherpetic…”
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An Evaluation of the Antirhinoviral Activity of Acylfuran Replacements for 3-Methylisoxazoles. Are 2-Acetylfurans Bioisosteres for 3-Methylisoxazoles? by Bailey, Thomas R, Diana, Guy D, Mallamo, John P, Vescio, Niranjan, Draper, Tandy L, Carabateas, Philip M, Long, Melody A, Giranda, Vincent L, Dutko, Frank J, Pevear, Daniel C

“…As a probe of the 3-methylisoxazole portion of our broad-spectrum antipicornaviral series, a panel of 2-acetylfuran analogues was prepared as replacements for…”
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An Evaluation of the Antirhinoviral Activity of Acylfuran Replacements for 3-Methylisoxazoles. Are 2-Acetylfurans Bioisosteres for 3-Methylisoxazoles? [Erratum to document cited in CA122:31229] by Bailey, Thomas R, Diana, Guy D, Mallamo, John P, Vescio, Niranjan, Draper, Tandy L, Carabateas, Philip M, Long, Melody A, Giranda, Vincent L, Dutko, Frank J, Pevear, Daniel C

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Synthesis and Evaluation of 6,11-Ethanohexahydrobenzo[b]quinolizidines: A New Class of Noncompetitive N-Methyl-D-aspartate Antagonists by Subramanyam, Chakrapani, Mallamo, John P, Pilling, Gary M, Earley, William G, Carabateas, Philip M, Wetzel, Joseph R, DeHaven-Hudkins, Diane, Allen, Timothy, Kullnig, Rudolph K

“…The synthesis and in vitro and in vivo evaluation of 12,13-cycloalkyl-6,11-ethanobenzo[b]-quinolizidines, a new class of noncompetitive N-methyl-D-aspartate…”
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Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating by Diana, Guy D, Oglesby, Richard C, Akullian, Vahan, Carabateas, Philip M, Cutcliffe, David, Mallamo, John P, Otto, Michael J, McKinlay, Mark A, Maliski, Edward G, Michalec, Stephen J

“…A series of substituted phenyl analogues of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles has been synthesized and evaluated in vitro…”
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Antiviral activity of some .beta.-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA viruses by Diana, Guy D, Salvador, U. Joseph, Zalay, Ethel S, Carabateas, Philip M, Williams, Gordon L, Collins, Joseph C, Pancic, Francis

“…A series of aryloxy alkyl diketones II was synthesized and screened in vitro for antiviral activity. The effect of various substituents on the phenyl ring, as…”
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Synthesis of 3-bromo- and 3-chloro-1-methyl-4-phenyl-4-propionoxypiperidines as potential analgetics by Carabateas, Philip M

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Synthesis and antiherpetic activity of some 4-[(aryloxy)alkyl]pyrazoles by Diana, Guy D, Carabateas, Philip M, Williams, Gordon L, Pancic, Francis, Steinberg, Bernard A

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Antiviral activity of some .beta.-diketones. 3. Aryl bis(.beta.-diketones). Antiherpetic activity by Diana, Guy D, Carabateas, Philip M, Salvador, U. Joseph, Williams, Gordon L, Zalay, Ethel S, Pancic, Francis, Steinberg, B. A, Collins, Joseph C

“…A series of bis(beta-diketones) was synthesized and tested in vitro for antiviral actitity against herpes simplex type 2. Two parameters which were studied in…”
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Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses by Diana, G. D, Carabateas, Philip M, Johnson, Robert E, Williams, Gordon L, Pancic, Francis, Collins, Joseph C

“…The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the…”
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Strong Analgesics. Some 1-Substituted 4-Acyl-4-phenylpiperidines by Elpern, Bill, Carabateas, Philip M, Grumbach, Leonard

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Strong Analgesics. Some 1-Substituted 4-Phenyl-4-Propionoxypiperidines by Carabateas, Philip M, Grumbach, Leonard

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Preparation of Triazines by the Reaction of Biguanide and Esters1 by Overberger, C. G, Michelotti, Francis W, Carabateas, Philip M

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C-Attached aminoalkylindoles: potent cannabinoid mimetics by D'Ambra, Thomas E., Eissenstat, Michael A., Abt, Jeffrey, Ackerman, James H., Bacon, Edward R., Bell, Malcolm R., Carabateas, Philip M., Josef, Kurt A., Kumar, Virendra, Weaver, John D., Arnold, Renee, Casiano, Frances M., Chippari, Susan M., Haycock, Dean A., Kuster, Joan E., Luttinger, Daniel A., Stevenson, Joan I., Ward, Susan J., Hill, W.Adam, Khanolkar, Atmaram, Makriyannis, Alexandros

“…Aminoalkylindoles (AAIs) with potent cannabinoid agonist activity have been synthesized where the aminoalkyl chain is attached to the indole ring via a carbon…”
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4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: A Novel Class III Antiarrhythmic Agents by Johnson, Robert E, Silver, Paul J, Becker, Russell, Birsner, Nancy C, Bohnet, Eric A, Briggs, G. Maurice, Busacca, Carl A, Canniff, Paul, Carabateas, Philip M, D'Ambra, Thomas, Dundore, Ronald L, Dung, Jen-Sen, Chadwick, Christopher C, Ezrin, Alan M, Gorczyca, William, Habeeb, Peter G, Horan, Patrick, Krafte, Douglas S, Pelling, Gary, O'Connor, Bernard, Saindane, Manohar T, Schlegel, Donald C, Stankus, Gerald P, Swestock, John, Volberg, Walter A

“…A series of 4,5-dihydro-3-[2-(methanesulfonamidophenyl)ethyl]-1-phenyl- 1H-2,4-benzodiazepines has been identified as potential antiarrhythmic agents that…”
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