Search Results - "Caprioli, M"
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Analysis of Tissue Specimens by Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry in Biological and Clinical Research
Published in Chemical reviews (10-04-2013)“…Matrix-Assisted Laser Desorption/Ionization (MALDI) is used to study complex biological systems. Molecules of biological specimens with a range of molecular…”
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Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry
Published in Mass spectrometry reviews (01-05-2020)“…Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that can map the spatial distribution of molecules with high chemical…”
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Matrix Sublimation/Recrystallization for Imaging Proteins by Mass Spectrometry at High Spatial Resolution
Published in Analytical chemistry (Washington) (15-07-2011)“…We have employed matrix deposition by sublimation for protein image analysis on tissue sections using a hydration/recrystallization process that produces…”
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Protein identification strategies in MALDI imaging mass spectrometry: a brief review
Published in Current opinion in chemical biology (01-02-2019)“…[Display omitted] Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial…”
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Molecular imaging by mass spectrometry — looking beyond classical histology
Published in Nature reviews. Cancer (01-09-2010)“…Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass…”
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Proteomic analysis of formalin-fixed paraffin-embedded tissue by MALDI imaging mass spectrometry
Published in Nature protocols (13-10-2011)“…Archived formalin-fixed paraffin-embedded (FFPE) tissue collections represent a valuable informational resource for proteomic studies. Multiple FFPE core…”
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Imaging mass spectrometry: Molecular microscopy for the new age of biology and medicine
Published in Proteomics (Weinheim) (01-06-2016)“…Imaging mass spectrometry provides a powerful tool for monitoring and discovery of molecular processes in the spatial domain in tissues for research and…”
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Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping
Published in Nature methods (01-04-2015)“…An approach to fuse images from imaging mass spectrometry and microscopy provides biological insights into molecular tissue distributions beyond what can be…”
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MALDI imaging mass spectrometry: Spatial molecular analysis to enable a new age of discovery
Published in Journal of proteomics (31-07-2014)“…Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) combines the sensitivity and selectivity of mass spectrometry with spatial…”
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Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry: In Situ Molecular Mapping
Published in Biochemistry (Easton) (04-06-2013)“…Matrix-assisted laser desorption ionization imaging mass spectrometry (IMS) is a relatively new imaging modality that allows mapping of a wide range of…”
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MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives
Published in Trends in biotechnology (Regular ed.) (01-03-2011)“…The molecular complexity of biological tissue and the spatial and temporal variation in the biological processes involved in human disease requires new…”
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Molecular imaging of proteins in tissues by mass spectrometry
Published in Proceedings of the National Academy of Sciences - PNAS (25-11-2008)“…Imaging MS (IMS) is an emerging technology that permits the direct analysis and determination of the distribution of molecules in tissue sections. Biological…”
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3D Imaging by Mass Spectrometry: A New Frontier
Published in Analytical chemistry (Washington) (06-03-2012)“…Imaging mass spectrometry can generate three-dimensional volumes showing molecular distributions in an entire organ or animal through registration and stacking…”
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Primed for Violence: The Role of Gender Inequality in Predicting Internal Conflict
Published in International studies quarterly (01-06-2005)“…We know, most notably through Ted Gurr's research, that ethnic discrimination can lead to ethnopolitical rebellion-intrastate conflict. I seek to discover what…”
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Absolute Quantitative MALDI Imaging Mass Spectrometry: A Case of Rifampicin in Liver Tissues
Published in Analytical chemistry (Washington) (16-02-2016)“…Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) elucidates molecular distributions in thin tissue sections. Absolute…”
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Imaging Mass Spectrometry: Enabling a New Age of Discovery in Biology and Medicine Through Molecular Microscopy
Published in Journal of the American Society for Mass Spectrometry (01-06-2015)“…Imaging mass spectrometry (IMS) has become a valuable tool for the production of molecular maps in samples ranging from solid inorganic materials to…”
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Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry
Published in Analytical chemistry (Washington) (06-10-2020)“…Low molecular weight metabolites are essential for defining the molecular phenotypes of cells. However, spatial metabolomics tools often lack the sensitivity,…”
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Non‐small cell lung cancer is characterized by dramatic changes in phospholipid profiles
Published in International journal of cancer (01-10-2015)“…Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death globally. To develop better diagnostics and more effective treatments, research in the…”
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MALDI-FTICR Imaging Mass Spectrometry of Drugs and Metabolites in Tissue
Published in Analytical chemistry (Washington) (15-07-2008)“…A new approach is described for imaging mass spectrometry analysis of drugs and metabolites in tissue using matrix-assisted laser desorption ionization-Fourier…”
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High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling
Published in Journal of mass spectrometry. (01-04-2015)“…A matrix‐assisted laser desorption/ionization time of flight/time of flight tandem mass spectrometer (MALDI TOF/TOF) has been used for high‐speed…”
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