Search Results - "Caprioli, Flavio"

A gut-vascular barrier controls the systemic dissemination of bacteria by Spadoni, Ilaria, Zagato, Elena, Bertocchi, Alice, Paolinelli, Roberta, Hot, Edina, Di Sabatino, Antonio, Caprioli, Flavio, Bottiglieri, Luca, Oldani, Amanda, Viale, Giuseppe, Penna, Giuseppe, Dejana, Elisabetta, Rescigno, Maria

“…In healthy individuals, the intestinal microbiota cannot access the liver, spleen, or other peripheral tissues. Some pathogenic bacteria can reach these sites,…”
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Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells by Burrello, Claudia, Garavaglia, Federica, Cribiù, Fulvia Milena, Ercoli, Giulia, Lopez, Gianluca, Troisi, Jacopo, Colucci, Angelo, Guglietta, Silvia, Carloni, Sara, Guglielmetti, Simone, Taverniti, Valentina, Nizzoli, Giulia, Bosari, Silvano, Caprioli, Flavio, Rescigno, Maria, Facciotti, Federica

“…Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation…”
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The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation by Amoroso, Chiara, Perillo, Federica, Strati, Francesco, Fantini, Massimo C, Caprioli, Flavio, Facciotti, Federica

“…Alterations of the gut microbiota may cause dysregulated mucosal immune responses leading to the onset of inflammatory bowel diseases (IBD) in genetically…”
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Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease by Monteleone, Giovanni, Neurath, Markus F, Ardizzone, Sandro, Di Sabatino, Antonio, Fantini, Massimo C, Castiglione, Fabiana, Scribano, Maria L, Armuzzi, Alessandro, Caprioli, Flavio, Sturniolo, Giacomo C, Rogai, Francesca, Vecchi, Maurizio, Atreya, Raja, Bossa, Fabrizio, Onali, Sara, Fichera, Maria, Corazza, Gino R, Biancone, Livia, Savarino, Vincenzo, Pica, Roberta, Orlando, Ambrogio, Pallone, Francesco

“…The chronic inflammation of Crohn's disease is caused, at least in part, by repression of TGF-β1 signaling, which is caused by high levels of SMAD7. This trial…”
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Antibiotic-associated dysbiosis affects the ability of the gut microbiota to control intestinal inflammation upon fecal microbiota transplantation in experimental colitis models by Strati, Francesco, Pujolassos, Meritxell, Burrello, Claudia, Giuffrè, Maria Rita, Lattanzi, Georgia, Caprioli, Flavio, Troisi, Jacopo, Facciotti, Federica

“…The gut microbiota plays a central role in host physiology and in several pathological mechanisms in humans. Antibiotics compromise the composition and…”
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Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin by Fornasa, Giulia, PhD, Tsilingiri, Katerina, PhD, Caprioli, Flavio, MD, PhD, Botti, Fiorenzo, MD, Mapelli, Marina, PhD, Meller, Stephan, MD, Kislat, Andreas, MSc, Homey, Bernhard, MD, Di Sabatino, Antonio, MD, Sonzogni, Angelica, MD, Viale, Giuseppe, MD, PhD, Diaferia, Giuseppe, PhD, Gori, Alessandro, PhD, Longhi, Renato, PhD, Penna, Giuseppe, MSc, Rescigno, Maria, PhD

“…Background Thymic stromal lymphopoietin (TSLP) is a cytokine with pleiotropic functions in the immune system. It has been associated with allergic reactions in…”
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Surface plasmon resonance unveils important pitfalls of enzyme-linked immunoassay for the detection of anti-infliximab antibodies in patients’ sera by Beeg, Marten, Burti, Cesare, Allocati, Eleonora, Ciafardini, Clorinda, Banzi, Rita, Nobili, Alessandro, Caprioli, Flavio, Garattini, Silvio, Gobbi, Marco

“…Measurements of serum concentrations of therapeutic antibodies and anti-drug antibodies (ADA) can support clinical decisions for the management of…”
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Probiotic Lactobacillus and Bifidobacterium Strains Counteract Adherent-Invasive Escherichia coli (AIEC) Virulence and Hamper IL-23/Th17 Axis in Ulcerative Colitis, but Not in Crohn's Disease by Leccese, Gabriella, Bibi, Alessia, Mazza, Stefano, Facciotti, Federica, Caprioli, Flavio, Landini, Paolo, Paroni, Moira

“…Hypersecretion of proinflammatory cytokines and dysregulated activation of the IL-23/Th17 axis in response to intestinal microbiota dysbiosis are key factors…”
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Budget impact analysis of the subcutaneous infliximab (CT-P13 SC) for treating inflammatory bowel disease in the Big-5 European (E5) countries by Yoo, Hyun Kyeong, Byun, Han Geul, Caprioli, Flavio, Fumery, Mathurin, Peyrin-Biroulet, Laurent, Sreedhar, Subramanian, Potter, James, Jang, Minyoung

“…Abstract Background In 2020, the European Medicines Agency approved infliximab subcutaneous (SC) for the treatment of inflammatory bowel disease. This new mode…”
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Nutrition in Patients with Inflammatory Bowel Diseases: A Narrative Review by Roncoroni, Leda, Gori, Rachele, Elli, Luca, Tontini, Gian Eugenio, Doneda, Luisa, Norsa, Lorenzo, Cuomo, Marialaura, Lombardo, Vincenza, Scricciolo, Alice, Caprioli, Flavio, Costantino, Andrea, Scaramella, Lucia, Vecchi, Maurizio

“…Inflammatory bowel diseases (IBD) affect the gastrointestinal tract: they include Crohn's disease (CD) and ulcerative colitis (UC). Each has a different…”
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Predicting Outcomes to Optimize Disease Management in Inflammatory Bowel Diseases by Torres, Joana, Caprioli, Flavio, Katsanos, Konstantinos H., Lobatón, Triana, Micic, Dejan, Zerôncio, Marco, Van Assche, Gert, Lee, James C., Lindsay, James O., Rubin, David T., Panaccione, Remo, Colombel, Jean-Frédéric

“…Abstract Background and Aims: Efforts to slow or prevent the progressive course of inflammatory bowel diseases [IBD] include early and intensive monitoring and…”
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Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway by Díaz‐Basabe, Angélica, Burrello, Claudia, Lattanzi, Georgia, Botti, Fiorenzo, Carrara, Alberto, Cassinotti, Elisa, Caprioli, Flavio, Facciotti, Federica

“…Invariant natural killer T (iNKT) cells are lipid‐specific T lymphocytes endowed with cytotoxic activities and are thus considered important in antitumor…”
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Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis by Di Giovangiulio, Martina, Rizzo, Angelamaria, Franzè, Eleonora, Caprioli, Flavio, Facciotti, Federica, Onali, Sara, Favale, Agnese, Stolfi, Carmine, Fehling, Hans-Joerg, Monteleone, Giovanni, Fantini, Massimo C

“…In normal conditions gut homeostasis is maintained by the suppressive activity of regulatory T cells (Tregs), characterized by the expression of the…”
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Rates of Adverse Events in Patients With Ulcerative Colitis Undergoing Colectomy During Treatment With Tofacitinib vs Biologics: A Multicenter Observational Study by Dragoni, Gabriele, Innocenti, Tommaso, Amiot, Aurelién, Castiglione, Fabiana, Melotti, Laura, Festa, Stefano, Savarino, Edoardo Vincenzo, Truyens, Marie, Argyriou, Konstantinos, Noviello, Daniele, Molnar, Tamas, Bouillon, Vincent, Bezzio, Cristina, Eder, Piotr, Fernandes, Samuel, Kagramanova, Anna, Armuzzi, Alessandro, Oliveira, Raquel, Viola, Anna, Ribaldone, Davide Giuseppe, Drygiannakis, Ioannis, Viganò, Chiara, Calella, Francesca, Gravina, Antonietta Gerarda, Pugliese, Daniela, Chaparro, María, Ellul, Pierre, Vieujean, Sophie, Milla, Monica, Caprioli, Flavio

“…Patients with ulcerative colitis (UC) receiving immunosuppressive drugs are at substantial risk of colectomy. We aimed to assess the risk of postoperative…”
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Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice by Farini, Andrea, Tripodi, Luana, Villa, Chiara, Strati, Francesco, Facoetti, Amanda, Baselli, Guido, Troisi, Jacopo, Landolfi, Annamaria, Lonati, Caterina, Molinaro, Davide, Wintzinger, Michelle, Gatti, Stefano, Cassani, Barbara, Caprioli, Flavio, Facciotti, Federica, Quattrocelli, Mattia, Torrente, Yvan

“…Duchenne muscular dystrophy (DMD) is a progressive severe muscle‐wasting disease caused by mutations in DMD , encoding dystrophin, that leads to loss of muscle…”
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S1 Risankizumab Versus Ustekinumab in Patients With Moderate to Severe Crohn’s Disease: Results From the Phase 3B SEQUENCE Trial by Peyrin-Biroulet, Laurent, Chapman, Casey, Colombel, Jean-Frederic, Caprioli, Flavio, D’Haens, Geert, Ferrante, Marc, Schreiber, Stefan, Atreya, Raja, Danese, Silvio, Lindsay, James O., Bossuyt, Peter, Siegmund, Britta, Irving, Peter, Panaccione, Remo, Neimark, Ezequiel, Wallace, Kori, Anschutz, Toni, Kligys, Kristina, Duan, W. Rachel, Pivorunas, Valerie, Huang, Xiu, Berg, Sofie, Shu, Lei, Dubinsky, Marla C.

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Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21 by Fina, Daniele, Sarra, Massimiliano, Fantini, Massimo C, Rizzo, Angelamaria, Caruso, Roberta, Caprioli, Flavio, Stolfi, Carmine, Cardolini, Iris, Dottori, Marta, Boirivant, Monica, Pallone, Francesco, MacDonald, Thomas T, Monteleone, Giovanni

“…Background & Aims: Interleukin (IL)-21, a T-cell-derived cytokine, is overproduced in inflammatory bowel diseases (IBD), but its role in the pathogenesis of…”
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Involvement of interleukin-21 in the regulation of colitis-associated colon cancer by Stolfi, Carmine, Rizzo, Angelamaria, Franzè, Eleonora, Rotondi, Angela, Fantini, Massimo Claudio, Sarra, Massimiliano, Caruso, Roberta, Monteleone, Ivan, Sileri, Pierpaolo, Franceschilli, Luana, Caprioli, Flavio, Ferrero, Stefano, MacDonald, Thomas T, Pallone, Francesco, Monteleone, Giovanni

“…Chronic inflammation is a major driving force in the development of cancer in many tissues, but the array of factors involved in this neoplastic transformation…”
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Interleukin-34 sustains inflammatory pathways in the gut by Franzè, Eleonora, Monteleone, Ivan, Cupi, Maria Laura, Mancia, Pamela, Caprioli, Flavio, Marafini, Irene, Colantoni, Alfredo, Ortenzi, Angela, Laudisi, Federica, Sica, Giuseppe, Sileri, PierPaolo, Pallone, Francesco, Monteleone, Giovanni

“…IBD (inflammatory bowel disease)-related tissue damage occurs in areas which are massively infiltrated with monocytes/macrophages. These cells respond to…”
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Absence of a role for interleukin‐13 in inflammatory bowel disease by Biancheri, Paolo, Di Sabatino, Antonio, Ammoscato, Francesca, Facciotti, Federica, Caprioli, Flavio, Curciarello, Renata, Hoque, Syed S., Ghanbari, Amir, Joe‐Njoku, Ijeoma, Giuffrida, Paolo, Rovedatti, Laura, Geginat, Jens, Corazza, Gino R., MacDonald, Thomas T.

“…IL‐13 has been implicated in the pathogenesis of ulcerative colitis (UC), and may have a role in animal models of gut fibrosis. We studied the involvement of…”
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