Search Results - "Cappon, GD"

Lack of direct bone effect of tofacitinib, a JAK inhibitor, in juvenile rats and evaluation of the association between offspring growth and femur length by Campion, SN, Potter, DM, Bowman, CJ, Catlin, NR, Davis, S., Millard, C., Nowland, WS, Stethem, CM, Hollingshead, BD, Radi, ZA, Coder, PS, Cappon, GD

“…Bone has recently emerged as a target organ for some Janus kinase (JAK) inhibitors in adult and/or juvenile animal toxicity studies. Oral administration of…”
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Effects of feed restriction during organogenesis on embryo-fetal development in rabbit by Cappon, G.D., Fleeman, T.L., Chapin, R.E., Hurtt, M.E.

“…BACKGROUND: Appropriate maternal nutrition and body weight gain during pregnancy is well established as a major factor in healthy prenatal development in…”
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Postnatal development of the gastrointestinal system: A species comparison by Walthall, Karen, Cappon, Gregg D., Hurtt, Mark E., Zoetis, Tracey

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Juvenile animal toxicity study designs to support pediatric drug development by Cappon, Gregg D., Bailey, Graham P., Buschmann, Jochen, Feuston, Maureen H., Fisher, J. Edward, Hew, Kok Wah, Hoberman, Alan M., Ooshima, Yojiro, Stump, Donald G., Hurtt, Mark E.

“…The objective of juvenile animal toxicity studies of pharmaceuticals is to obtain safety data, including information on the potential for adverse effects on…”
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Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food-producing animals by Hurtt, M.E., Cappon, G.D., Browning, A.

“…In order to establish the safety of veterinary drug residues in human food, a number of toxicological evaluations are required, including the assessment of…”
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Species comparison of postnatal CNS development: Functional measures by Wood, Sandra L., Beyer, Bruce K., Cappon, Gregg D.

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Sensitive Windows of Skeletal Development in Rabbits Determined by Hydroxyurea Exposure at Different Times throughout Gestation by Campion, Sarah N., Davenport, Scott J., Nowland, William S., Cappon, Gregg D., Bowman, Christopher J., Hurtt, Mark E.

“…The critical periods of axial skeletal development in rats and mice have been well characterized, however the timing of skeletal development in rabbits is not…”
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Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure by Cappon, G. D., Cook, J. C., Hurtt, M. E.

“…BACKGROUND: A review of the scientific literature suggested the occurrence of low‐level incidences of ventricular septal defect (VSD) and midline defect (MD)…”
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A single dose model of methamphetamine-induced neurotoxicity in rats: effects on neostriatal monoamines and glial fibrillary acidic protein by Fukumura, Masao, Cappon, Gregg D, Pu, Cunfeng, Broening, Harry W, Vorhees, Charles V

“…The neurotoxic effects of a single administration of methamphetamine (MA) were studied under conditions conducive to MA-induced hyperthermia. After a single…”
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Time-course of methamphetamine-induced neurotoxicity in rat caudate-putamen after single-dose treatment by Cappon, Gregg D, Pu, Cunfeng, Vorhees, Charles V

“…The time-course of monoamine and tyrosine hydroxylase depletion after single-dose administration of d-methamphetamine (40 mg/kg s.c.) was investigated in…”
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The effects of feed restriction during organogenesis on embryo-fetal development in the rat by Fleeman, T.L., Cappon, G.D., Chapin, R.E., Hurtt, M.E.

“…BACKGROUND: Given the role of nutrition and body weight gain in normal development, pharmaceuticals intended to reduce appetite and promote weight loss will…”
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Postnatal closure of membranous ventricular septal defects in Sprague-Dawley rat pups after maternal exposure with trimethadione by Fleeman, Tammye L., Cappon, Gregg D., Hurtt, Mark E.

“…BACKGROUND: Congenital membranous ventricular septal defects (VSD) have been shown to close during postnatal development in rats [Solomon et al., Teratology…”
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Reproductive toxicity assessment of lasofoxifene, a selective estrogen receptor modulator (SERM), in male rats by Cappon, Gregg D., Horimoto, Masao, Hurtt, Mark E.

“…BACKGROUND: Lasofoxifene is a nonsteroidal selective estrogen receptor modulator (SERM) with greater than 100‐fold selectivity against all other steroid…”
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Juvenile animal studies: Testing strategies and design by Hurtt, M.E., Daston, G., Davis-Bruno, K., Feuston, M., Silva Lima, B., Makris, S., McNerney, M.E., Sandler, J.D., Whitby, K., Wier, P., Cappon, G.D.

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Plasma and brain methamphetamine concentrations in neonatal rats by Cappon, Gregg D, Vorhees, Charles V

“…d-Methamphetamine ( d-MA) treatment during the neonatal period has been shown to induce acoustic startle hyperreactivity and Morris maze spatial learning…”
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Combined Treatment Potentiates the Developmental Toxicity of Ibuprofen and Acetazolamide in Rats by Cappon, Gregg D., Fleeman, T. L., Cook, J. C., Hurtt, M. E.

“…Aspirin (ASA), an irreversible cyclooxygenase (COX) inhibitor, induces ventricular septal defect (VSD) and diaphragmatic hernia (DH) in rat fetuses when…”
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The effects of amfonelic acid, a dopamine uptake inhibitor, on methamphetamine-induced dopaminergic terminal degeneration and astrocytic response in rat striatum by Pu, C, Fisher, J E, Cappon, G D, Vorhees, C V

“…Administration of methamphetamine (MA) induces degeneration of dopaminergic nerve terminals and astrogliosis, such as hypertrophy and an increase in apparent…”
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Reproductive toxicity assessment of lasofoxifene, a selective estrogen receptor modulator (SERM), in female rats by Terry, K.K., Cappon, G.D., Hurtt, M.E., Tassinari, M.S., Gupta, U.

“…BACKGROUND: Lasofoxifene is a nonsteroidal selective estrogen receptor modulator (SERM). With high affinity to the α and β human estrogen receptors and greater…”
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Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development by Cappon, G. D., Gupta, U., Cook, J. C., Tassinari, M. S., Hurtt, M. E.

“…BACKGROUND: A review of the nonsteroidal anti‐inflammatory drug (NSAID) literature suggested occurrences of low‐level incidences of cardiovascular and midline…”
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Methamphetamine-Induced Dopamine and Serotonin Reductions in Neostriatum Are Not Gender Specific in Rats with Comparable Hyperthermic Responses by Fukumura, Masao, Cappon, Gregg D., Broening, Harry W., Vorhees, Charles V.

“…Methamphetamine (MA)-induced monoamine depletions in male and female Sprague–Dawley CD rats were studied under conditions in which the magnitude of MA-induced…”
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