Search Results - "Cappoli, Natalia"

The human microglial HMC3 cell line: where do we stand? A systematic literature review by Dello Russo, Cinzia, Cappoli, Natalia, Coletta, Isabella, Mezzogori, Daniele, Paciello, Fabiola, Pozzoli, Giacomo, Navarra, Pierluigi, Battaglia, Alessandra

“…Microglia, unique myeloid cells residing in the brain parenchyma, represent the first line of immune defense within the central nervous system. In addition to…”
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A comparison between the assessments of progression-free survival by local investigators versus blinded independent central reviews in phase III oncology trials by Dello Russo, Cinzia, Cappoli, Natalia, Navarra, Pierluigi

“…Purpose In this study, we compared the assessments of progression-free survival (PFS) carried out by the local investigator or by a blinded independent central…”
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Remifentanil does not affect human microglial immune activation in response to pro-inflammatory cytokines by Dello Russo, Cinzia, Cappoli, Natalia, Tabolacci, Elisabetta, Sollazzi, Liliana, Navarra, Pierluigi, Aceto, Paola

“…Remifentanil is a potent ultra-short acting μ-opioid analgesic drug, frequently used in anaesthesia due to its favorable pharmacodynamic and pharmacokinetic…”
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The emerging role of the BDNF-TrkB signaling pathway in the modulation of pain perception by Cappoli, Natalia, Tabolacci, Elisabetta, Aceto, Paola, Dello Russo, Cinzia

“…The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain transmission both in peripheral and central nervous system (CNS). Despite…”
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LAT1, a novel pharmacological target for the treatment of glioblastoma by Cappoli, Natalia, Jenkinson, Michael D., Dello Russo, Cinzia, Dickens, David

“…[Display omitted] The L-Type Amino Acid transporter, LAT1 (SLC7A5), has a crucial role in mediating amino acid uptake into the cells, thus modulating cell…”
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Remifentanil-induced hyperalgesia in healthy volunteers: a systematic review and meta-analysis of randomized controlled trials by Dello Russo, Cinzia, Di Franco, Valeria, Tabolacci, Elisabetta, Cappoli, Natalia, Navarra, Pierluigi, Sollazzi, Liliana, Rapido, Francesca, Aceto, Paola

“…Recent literature suggests that the withdrawal of remifentanil (RF) infusion can be associated with hyperalgesia in clinical and nonclinical settings. We…”
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Local Investigators Significantly Overestimate Overall Response Rates Compared to Blinded Independent Central Reviews in Phase 2 Oncology Trials by Dello Russo, Cinzia, Cappoli, Natalia, Pilunni, Daniela, Navarra, Pierluigi

“…The overall response rate (ORR) is a largely adopted outcome measure in early‐phase oncology trials. ORR is highly relevant in cancer drug development at the…”
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Exploring the Control of PARP1 Levels in High-Grade Serous Ovarian Cancer by Raspaglio, Giuseppina, Buttarelli, Marianna, Cappoli, Natalia, Ciucci, Alessandra, Fagotti, Anna, Scambia, Giovanni, Gallo, Daniela

“…High-grade serous ovarian cancer (HGSOC) is a leading cause of mortality from gynecologic malignancies worldwide. Although a transformative improvement has…”
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The mTOR kinase inhibitor rapamycin enhances the expression and release of pro-inflammatory cytokine interleukin 6 modulating the activation of human microglial cells by Cappoli, Natalia, Mezzogori, Daniele, Tabolacci, Elisabetta, Coletta, Isabella, Navarra, Pierluigi, Pani, Giovambattista, Dello Russo, Cinzia

“…Emerging evidence suggests the potential use of rapamycin in treatment of several neurological disorders. The drug readily crosses the blood brain barrier and…”
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