Search Results - "Cappiello, John R"

Chain-Growth Sulfur(VI) Fluoride Exchange Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates by Kim, Hyunseok, Zhao, Jiayu, Bae, Jinhye, Klivansky, Liana M, Dailing, Eric A, Liu, Yi, Cappiello, John R, Sharpless, K. Barry, Wu, Peng

“…Sulfur­(VI) fluoride exchange (SuFEx) click chemistry has offered a facile and reliable approach to produce polysulfates and polysulfonates. However, the…”
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Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry by Kitamura, Seiya, Zheng, Qinheng, Woehl, Jordan L, Solania, Angelo, Chen, Emily, Dillon, Nicholas, Hull, Mitchell V, Kotaniguchi, Miyako, Cappiello, John R, Kitamura, Shinichi, Nizet, Victor, Sharpless, K. Barry, Wolan, Dennis W

“…Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and resource-intensive process. Lack of automation and reliance on…”
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Identification of simple arylfluorosulfates as potent agents against resistant bacteria by Zhang, Jiong, Zhao, Xiangxiang, Cappiello, John R., Yang, Yi, Cheng, Yunfei, Liu, Guang, Fang, Wenjing, Luo, Yinzhu, Zhang, Yu, Dong, Jiajia, Zhang, Lixin, Sharpless, K. Barry

“…Sulfur fluoride exchange (SuFEx), a next generation of click chemistry, opens an avenue for drug discovery. We report here the discovery and structure–activity…”
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Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors by Cheng, Yunfei, Li, Gencheng, Smedley, Christopher J, Giel, Marie-Claire, Kitamura, Seiya, Woehl, Jordan L, Bianco, Giulia, Forli, Stefano, Homer, Joshua A, Cappiello, John R, Wolan, Dennis W, Moses, John E, Sharpless, K Barry

“…Diversity Oriented Clicking (DOC) is a discovery method geared toward the rapid synthesis of functional libraries. It combines the best attributes of both…”
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Chemoenzymatic Tagging of Tn/TF/STF Antigens in Living Systems by Yang, Yi, Chen, Mingkuan, Wu, Mengyao, Hong, Senlian, Gao, Bing, Liu, Yonghui, Yu, Chenhua, Young, Travis S., Chapla, Digantkumar Gopaldas, Yang, Jeong‐Yeh, Cappiello, John R., Li, Jie P., Sharpless, K. Barry, Moremen, Kelley W., Wu, Peng

“…Truncated mucin‐type O‐glycans, such as Tn‐associated antigens, are aberrantly expressed biomarkers of cancer, but remain challenging to target. Reactive…”
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