Search Results - "Cappai, R"

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke by Tuo, Q-z, Lei, P, Jackman, K A, Li, X-l, Xiong, H, Li, X-l, Liuyang, Z-y, Roisman, L, Zhang, S-t, Ayton, S, Wang, Q, Crouch, P J, Ganio, K, Wang, X-c, Pei, L, Adlard, P A, Lu, Y-m, Cappai, R, Wang, J-z, Liu, R, Bush, A I

“…Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as iron accumulates in ischemic stroke tissue, we hypothesized that…”
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Solution studies, synthesis and antibacterial activity of Ga(III) complexes with bis-kojate derivatives by O'Ferrall, L. More, Fantasia, A., Chan, K., Teixeira, L.M., Kavanagh, K., O'Connor, C., Santos, M.A., Chaves, S., Nurchi, V.M., Crisponi, G., Zoroddu, M.A., Griffith, D.M., Cappai, R.

“…Given the recognized major problem of microbial drug resistance for human health, new metal-based drugs have been currently explored for their antimicrobial…”
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Packaging of prions into exosomes is associated with a novel pathway of PrP processing by Vella, LJ, Sharples, RA, Lawson, VA, Masters, CL, Cappai, R, Hill, AF

“…Prion diseases are fatal, transmissible neurodegenerative disorders associated with conversion of the host‐encoded prion protein (PrPC) into an abnormal…”
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Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth by Needham, BE, Wlodek, ME, Ciccotosto, GD, Fam, BC, Masters, CL, Proietto, J, Andrikopoulos, S, Cappai, R

“…The amyloid precursor protein (APP), the source of the neurotoxic amyloid β (Aβ) peptide involved in Alzheimer's disease (AD), belongs to a conserved family of…”
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The amyloid precursor protein of Alzheimer's disease and the Aβ peptide by STOREY, E, CAPPAI, R

“…Alzheimer’s disease is characterized by the accumulation of beta amyloid peptides in plaques and vessel walls and by the intraneuronal accumulation of paired…”
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Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126 by Jobling, Michael F, Huang, Xudong, Stewart, Leanne R, Barnham, Kevin J, Curtain, Cyril, Volitakis, Irene, Perugini, Matthew, White, Anthony R, Cherny, Robert A, Masters, Colin L, Barrow, Colin J, Collins, Steven J, Bush, Ashley I, Cappai, Roberto

“…The abnormal form of the prion protein (PrP) is believed to be responsible for the transmissible spongiform encephalopathies. A peptide encompassing residues…”
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Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers by Robert, Remy, Dolezal, Olan, Waddington, Lynne, Hattarki, Meghan K., Cappai, Roberto, Masters, Colin L., Hudson, Peter J., Wark, Kim L.

“…Most neurodegenerative disorders, such as Alzheimer's (AD), Parkinson's, Huntington's and Creutzfeldt–Jakob disease, are characterised by the accumulation of…”
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It all sticks together: the APP-related family of proteins and Alzheimer's disease by BAYER, T. A, CAPPAI, R, MASTERS, C. L, BEYREUTHER, K, MULTHAUP, G

“…In the present review, we shall discuss the pros and cons of a possible functional relationship and contribution of the APP family members (APP, APLP1 and…”
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Sublethal Concentrations of Prion Peptide PrP106–126 or the Amyloid Beta Peptide of Alzheimer's Disease Activates Expression of Proapoptotic Markers in Primary Cortical Neurons by White, Anthony R., Guirguis, Ronald, Brazier, Marcus W., Jobling, Michael F., Hill, Andrew F., Beyreuther, Konrad, Barrow, Colin J., Masters, Colin L., Collins, Steven J., Cappai, Roberto

“…Neurodegenerative disorders such as prion diseases and Alzheimer's disease (AD) are characterized by neuronal dysfunction and accumulation of amyloidogenic…”
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P1.050 Novel neuroprotective agents for the treatment of Parkinson's disease by George, J, Wilkins, S, Critch, N, Gunawan, L, Cortes, M, Liu, X, Laughton, K, Nurjono, M, Volitakis, I, Huggins, P, Parsons, J, McNaughton, M, Adlard, P, Masters, C, Cappai, R, Barnham, K, Gautier, E, Bush, A, Cherny, R, Finkelstein, D.I

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P2.097 A reactive nitrogen species scavenger is neuroprotective in multiple Parkinson's disease animal models by Hung, L, Roberts, B, Wilkins, S, George, J, Pham, C, Lim, S, Crouch, P, Nurjono, M, Gunawan, L, Critch, N, Sherratt, N, Cherny, R, Bush, A, Masters, C, Culvenor, J, Cappai, R, White, A, Donnelly, P, Villemagne, V, Finkelstein, D, Barnham, K

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Generation of a recombinant Fab antibody reactive with the Alzheimer's disease‐related Aβ peptide by TAMMER, A. H., COIA, G., CAPPAI, R., FULLER, S., MASTERS, C. L., HUDSON, P., UNDERWOOD, J. R.

“…SUMMARY A recombinant Fab antibody, designated 1E8–4b, which reacts with the Alzheimer's disease (AD)‐related Aβ peptides, Aβ[1–40], Aβ[1–42] and Aβ[1–43] has…”
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Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments by Kourie, J I, Kenna, B L, Tew, D, Jobling, M F, Curtain, C C, Masters, C L, Barnham, K J, Cappai, R

“…We have shown previously that the protease-resistant and neurotoxic prion peptide fragment PrP[106-126] of human PrP incorporates into lipid bilayer membranes…”
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18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease by Fodero-Tavoletti, Michelle T, Okamura, Nobuyuki, Furumoto, Shozo, Mulligan, Rachel S, Connor, Andrea R, McLean, Catriona A, Cao, Diana, Rigopoulos, Angela, Cartwright, Glenn A, O'Keefe, Graeme, Gong, Sylvia, Adlard, Paul A, Barnham, Kevin J, Rowe, Christopher C, Masters, Colin L, Kudo, Yukitsuka, Cappai, Roberto, Yanai, Kazuhiko, Villemagne, Victor L

“…While considerable effort has focused on developing positron emission tomography β-amyloid imaging radiotracers for the early diagnosis of Alzheimer's disease,…”
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La Lunga Attesa: Towards a Molecular Approach to Neuroimaging and Therapeutics in Alzheimer's Disease by Villemagne, V.L., Ng, S., Cappai, R., Barnham, K.J., Fodero-Tavoletti, M.T., Rowe, C.C., Masters, C.L.

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by the gradual onset of dementia. The pathological hallmarks of the disease…”
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Familial Prion Disease Mutation Alters the Secondary Structure of Recombinant Mouse Prion Protein:  Implications for the Mechanism of Prion Formation by Cappai, Roberto, Stewart, Leanne, Jobling, Michael F, Thyer, James M, White, Anthony R, Beyreuther, Konrad, Collins, Steven J, Masters, Colin L, Barrow, Colin J

“…A considerable body of data supports the model that the infectious agent (called a prion) which causes the transmissible spongiform encephalopathies is a…”
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Differential effects of zinc on amyloid precursor protein (APP) processing in copper-resistant variants of cultured Chinese hamster ovary cells by Borchardt, T, Schmidt, C, Camarkis, J, Cappai, R, Masters, C L, Beyreuther, K, Multhaup, G

“…Previous studies have demonstrated that adding copper to Chinese-hamster ovary (CHO) cells greatly reduced the levels of beta-amyloid (Abeta) peptide in…”
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The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury by Plummer, Stephanie, Van den Heuvel, Corinna, Thornton, Emma, Corrigan, Frances, Cappai, Roberto

“…Despite the significant health and economic burden that traumatic brain injury (TBI) places on society, the development of successful therapeutic agents have…”
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Alzheimer's disease : Correlation of the suppression of β-amyloid Peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome by CHRISTIE, G, MARKWELL, R. E, WARD, R. V, HOWLETT, D. R, HARTMANN, T, LICHTENTHALER, S. F, BEYREUTHER, K, UNDERWOOD, J, GRIBBLE, S. K, CAPPAI, R, MASTERS, C. L, TAMAOKA, A, GRAY, C. W, GARDNER, R. L, RIVETT, A. J, KARRAN, E. H, ALLSOP, D, SMITH, L, GODFREY, F, MANSFIELD, F, WADSWORTH, H, KING, R, MCLAUGHLIN, M, COOPER, D. G

“…Peptide aldehyde inhibitors of the chymotrypsin-like activity of the proteasome (CLIP) such as N-acetyl-Leu-Leu-Nle-H (or ALLN) have been shown previously to…”
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Prions in skeletal muscle by BRAZIER, MW, CAPPAI, R., COLLINS, SJ

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