Search Results - "Cappabianca, Lucia"

Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer by Farina, Antonietta Rosella, Cappabianca, Lucia, Sebastiano, Michela, Zelli, Veronica, Guadagni, Stefano, Mackay, Andrew Reay

“…Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of…”
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Doxorubicin-Induced TrkAIII Activation: A Selection Mechanism for Resistant Dormant Neuroblastoma Cells by Cappabianca, Lucia, Sebastiano, Michela, Ruggieri, Marianna, Sbaffone, Maddalena, Zelli, Veronica, Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Patients with advanced neuroblastoma (NB) receive multimodal clinical therapy, including the potent anthracycline chemotherapy drug doxorubicin (Dox). The…”
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Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells by Cappabianca, Lucia, Ruggieri, Marianna, Sebastiano, Michela, Sbaffone, Maddalena, Martelli, Ilaria, Ruggeri, Pierdomenico, Di Padova, Monica, Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Pediatric neuroblastomas (NBs) are heterogeneous, aggressive, therapy-resistant embryonal tumors that originate from cells of neural crest origin committed to…”
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Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma by Cappabianca, Lucia, Farina, Antonietta Rosella, Di Marcotullio, Lucia, Infante, Paola, De Simone, Daniele, Sebastiano, Michela, Mackay, Andrew Reay

“…Identification of novel cancer-associated splice variants is of potential diagnostic, prognostic and therapeutic importance. NF-Y transcription factor is…”
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The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII by Farina, Antonietta Rosella, Cappabianca, Lucia, Ruggeri, Pierdomenico, Gneo, Luciana, Pellegrini, Cristina, Fargnoli, Maria-Concetta, Mackay, Andrew Reay

“…Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This,…”
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A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target by Cappabianca, Lucia, Guadagni, Stefano, Maccarone, Rita, Sebastiano, Michela, Chiominto, Alessandro, Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates. The…”
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A Study of Alternative TrkA Splicing Identifies TrkAIII as a Novel Potentially Targetable Participant in PitNET Progression by Sbaffone, Maddalena, Jaffrain-Rea, Marie-Lise, Cappabianca, Lucia, Carbonara, Francesca, Gianno, Francesca, Feola, Tiziana, Ruggieri, Marianna, Zelli, Veronica, Maccarone, Rita, Guadagni, Stefano, Clementi, Marco, Arcella, Antonietta, Esposito, Vincenzo, Carozza, Giulia, Martelli, Ilaria, Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Pituitary neuroendocrine tumors (PitNETs) are generally benign but comprise an aggressive, invasive, therapy-resistant, metastatic subset, underpinning a need…”
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The TrkAIII oncoprotein inhibits mitochondrial free radical ROS-induced death of SH-SY5Y neuroblastoma cells by augmenting SOD2 expression and activity at the mitochondria, within the context of a tumour stem cell-like phenotype by Ruggeri, Pierdomenico, Farina, Antonietta R, Di Ianni, Natalia, Cappabianca, Lucia, Ragone, Marzia, Ianni, Giulia, Gulino, Alberto, Mackay, Andrew R

“…The developmental and stress-regulated alternative TrkAIII splice variant of the NGF receptor TrkA is expressed by advanced stage human neuroblastomas (NBs),…”
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The Alternative TrkAIII Splice Variant, a Targetable Oncogenic Participant in Human Cutaneous Malignant Melanoma by Cappabianca, Lucia, Zelli, Veronica, Pellegrini, Cristina, Sebastiano, Michela, Maccarone, Rita, Clementi, Marco, Chiominto, Alessandro, Ruggeri, Pierdomenico, Cardelli, Ludovica, Ruggieri, Marianna, Sbaffone, Maddalena, Fargnoli, Maria-Concetta, Guadagni, Stefano, Farina, Antonietta R, Mackay, Andrew R

“…Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets and strategies in cutaneous malignant…”
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Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6-7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related Kinase A by Guadagni, Stefano, Farina, Antonietta Rosella, Cappabianca, Lucia Annamaria, Sebastiano, Michela, Maccarone, Rita, Zelli, Veronica, Clementi, Marco, Chiominto, Alessandro, Bruera, Gemma, Ricevuto, Enrico, Fiorentini, Giammaria, Sarti, Donatella, Mackay, Andrew Reay

“…Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which are caused by the genomic integration of…”
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Nutraceutical Preventative and Therapeutic Potential in Neuroblastoma: From Pregnancy to Early Childhood by Sbaffone, Maddalena, Ruggieri, Marianna, Sebastiano, Michela, Mackay, Andrew Reay, Zelli, Veronica, Farina, Antonietta Rosella, Cappabianca, Lucia Annamaria

“…Neuroblastoma (NB) is a highly malignant embryonic extracranial solid tumor that arises from sympathoadrenal neuroblasts of neural crest origin. In addition to…”
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The Alternative TrkAIII Splice Variant Targets the Centrosome and Promotes Genetic Instability by Farina, Antonietta Rosella, Tacconelli, Antonella, Cappabianca, Lucia, Cea, Gesilia, Panella, Sonia, Chioda, Antonella, Romanelli, Alessandra, Pedone, Carlo, Gulino, Alberto, Mackay, Andrew Reay

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nature of the Accessible Chromatin at a Glucocorticoid-Responsive Enhancer by Flavin, Michelle, Cappabianca, Lucia, Kress, Clémence, Thomassin, Hélène, Grange, Thierry

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Alternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma by Tacconelli, Antonella, Farina, Antonietta R, Cappabianca, Lucia, Gulino, Alberto, Mackay, Andrew R

“…An association between elevated tyrosine kinase receptor (Trk)-A expression and better prognosis; the absence of mutation-activated TrkA oncogenes; the…”
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In vivo analysis of the model tyrosine aminotransferase gene reveals multiple sequential steps in glucocorticoid receptor action by Grange, T, Cappabianca, L, Flavin, M, Sassi, H, Thomassin, H

“…We are studying the mechanisms of transcriptional activation by nuclear receptors and we focus our studies on the glucocorticoid regulation of the model…”
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TrkAIII: A Novel Hypoxia-regulated Alternative TrkA Splice Variant of Potential Physiological and Pathological Importance by Tacconelli, Antonella, Farina, Antonietta R., Cappabianca, Lucia, Gulino, Alberto, Mackay, Andrew R.

“…Nerve growth factor receptor TrkA is critical for development and maturation of central and peripheral nervous systems, regulating proliferation,…”
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TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation by Farina, Antonietta Rosella, Cappabianca, Lucia, Gneo, Luciana, Ruggeri, Pierdomenico, Mackay, Andrew Reay

“…Alternative TrkAIII splicing characterises advanced stage metastatic disease and post-therapeutic relapse in neuroblastoma (NB), and in NB models TrkAIII…”
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Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting by Farina, Antonietta Rosella, Cappabianca, Lucia Annamaria, Zelli, Veronica, Sebastiano, Michela, Mackay, Andrew Reay

“…Pediatric neuroblastomas (NBs) are heterogeneous, aggressive, therapy-resistant embryonal tumours that originate from cells of neural crest (NC) origin and in…”
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Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity by Farina, Antonietta Rosella, Cappabianca, Lucia, Ruggeri, Pierdomenico, Gneo, Luciana, Maccarone, Rita, Mackay, Andrew Reay

“…In human SH-SY5Y neuroblastoma (NB) cells, nascent immature N-glycosylated 110kDa TrkA moves rapidly from the endoplasmic reticulum (ER) to the Golgi Network…”
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Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK‐N‐SH neuroblastoma cell invasion by Farina, Antonietta R., Tacconelli, Antonella, Cappabianca, Lucia, Masciulli, Maria‐Paola, Holmgren, Arne, Beckett, Geoffery J., Gulino, Alberto, Mackay, Andrew R.

“…Thioredoxin (Trx) inhibited tissue inhibitor of metalloproteinase (TIMP)‐1 and TIMP‐2 activity with an approximate IC50 of 0.3 µm, matrix metalloproteinase…”
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