Search Results - "Capone, Emily"

Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target by Capone, Emily, Iacobelli, Stefano, Sala, Gianluca

“…The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was…”
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Antibody-Drug Conjugates: The New Frontier of Chemotherapy by Ponziani, Sara, Di Vittorio, Giulia, Pitari, Giuseppina, Cimini, Anna Maria, Ardini, Matteo, Gentile, Roberta, Iacobelli, Stefano, Sala, Gianluca, Capone, Emily, Flavell, David J, Ippoliti, Rodolfo, Giansanti, Francesco

“…In recent years, antibody-drug conjugates (ADCs) have become promising antitumor agents to be used as one of the tools in personalized cancer medicine. ADCs…”
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HER3 targeting with an antibody‐drug conjugate bypasses resistance to anti‐HER2 therapies by Gandullo‐Sánchez, Lucía, Capone, Emily, Ocaña, Alberto, Iacobelli, Stefano, Sala, Gianluca, Pandiella, Atanasio

“…Despite impressive clinical benefit obtained with anti‐HER2‐targeted therapies, in advances stages, especially in the metastatic setting, HER2‐positive tumors…”
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Extracellular LGALS3BP: a potential disease marker and actionable target for antibody–drug conjugate therapy in glioblastoma by Dufrusine, Beatrice, Capone, Emily, Ponziani, Sara, Lattanzio, Rossano, Lanuti, Paola, Giansanti, Francesco, De Laurenzi, Vincenzo, Iacobelli, Stefano, Ippoliti, Rodolfo, Mangiola, Annunziato, Trevisi, Gianluca, Sala, Gianluca

“…Glioblastoma multiforme (GBM) is a lethal disease characterized by an overall survival of about 1 year, making it one of the most aggressive tumours, with very…”
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Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer by Adamska, Aleksandra, Domenichini, Alice, Capone, Emily, Damiani, Verena, Akkaya, Begum Gokcen, Linton, Kenneth J, Di Sebastiano, Pierluigi, Chen, Xi, Keeton, Adam B, Ramirez-Alcantara, Veronica, Maxuitenko, Yulia, Piazza, Gary A, De Laurenzi, Vincenzo, Sala, Gianluca, Falasca, Marco

“…Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive and lethal disease, lacking effective therapeutic approaches. Available therapies only marginally…”
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Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer by Emmanouilidi, Aikaterini, Fyffe, Chanse A, Ferro, Riccardo, Edling, Charlotte E, Capone, Emily, Sestito, Simona, Rapposelli, Simona, Lattanzio, Rossano, Iacobelli, Stefano, Sala, Gianluca, Maffucci, Tania, Falasca, Marco

“…The very aggressive nature and low survival rate of pancreatic ductal adenocarcinoma (PDAC) dictates the necessity to find novel efficacious therapies. Recent…”
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MYC regulates metabolism through vesicular transfer of glycolytic kinases by Tsakaneli, Alexia, Carregari, Victor Corasolla, Morini, Martina, Eva, Alessandra, Cangemi, Giuliana, Chayka, Olesya, Makarov, Evgeny, Bibbò, Sandra, Capone, Emily, Sala, Gianluca, De Laurenzi, Vincenzo, Poon, Evon, Chesler, Louis, Pieroni, Luisa, Larsen, Martin R, Palmisano, Giuseppe, Sala, Arturo

“…Amplification of the proto-oncogene is a key molecular aberration in high-risk neuroblastoma and predictive of poor outcome in this childhood malignancy. We…”
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HER-3 surface expression increases in advanced colorectal cancer representing a potential therapeutic target by Capone, Emily, Tryggvason, Thordur, Cela, Ilaria, Dufrusine, Beatrice, Pinti, Morena, Del Pizzo, Francesco, Gunnarsdottir, Helga Sigrun, Grottola, Tommaso, De Laurenzi, Vincenzo, Iacobelli, Stefano, Lattanzio, Rossano, Sala, Gianluca

“…HER-3 (also known as ErbB-3) is a human epidermal growth factor receptor tyrosine kinases family member, and its expression in CRC (colorectal cancer) tissues…”
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EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors by Capone, Emily, Lattanzio, Rossano, Gasparri, Fabio, Orsini, Paolo, Rossi, Cosmo, Iacobelli, Valentina, De Laurenzi, Vincenzo, Natali, Pier Giorgio, Valsasina, Barbara, Iacobelli, Stefano, Sala, Gianluca

“…HER-3 is becoming an attractive target for antibody-drug conjugate (ADC)-based therapy. Indeed, this receptor and its ligands are found to be overexpressed in…”
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Extracellular vesicles in glioblastoma: Biomarkers and therapeutic tools by Cela, Ilaria, Capone, Emily, Trevisi, Gianluca, Sala, Gianluca

“…Glioblastoma (GBM) is the most aggressive tumor among the gliomas and intracranial tumors and to date prognosis for GBM patients remains poor, with a median…”
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HPLC-DAD validated method for DM4 and its metabolite S-Me-DM4 quantification in biological matrix for clinical and pharmaceutical applications by Lovato, Giulio, Ciriolo, Luigi, Perrucci, Miryam, Federici, Luca, Ippoliti, Rodolfo, Iacobelli, Stefano, Capone, Emily, Locatelli, Marcello, Sala, Gianluca

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EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma by Capone, Emily, Lamolinara, Alessia, D'Agostino, Daniela, Rossi, Cosmo, De Laurenzi, Vincenzo, Iezzi, Manuela, Iacobelli, Stefano, Sala, Gianluca

“…Cutaneous melanoma is one of the cancers with the fastest rising incidence and in its advanced metastatic form is a highly lethal disease. Despite the recent…”
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EV20/Omomyc: A novel dual MYC/HER3 targeting immunoconjugate by Bibbò, Sandra, Capone, Emily, Lovato, Giulio, Ponziani, Sara, Lamolinara, Alessia, Iezzi, Manuela, Lattanzio, Rossano, Mazzocco, Katia, Morini, Martina, Giansanti, Francesco, De Laurenzi, Vincenzo, Whitfield, Jonathan, Iacobelli, Stefano, Ippoliti, Rodolfo, Beaulieu, Marie-Eve, Soucek, Laura, Sala, Arturo, Sala, Gianluca

“…MYC is one of the most important therapeutic targets in human cancer. Many attempts have been made to develop small molecules that could be used to curb its…”
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Secreted Gal-3BP is a novel promising target for non-internalizing Antibody–Drug Conjugates by Giansanti, Francesco, Capone, Emily, Ponziani, Sara, Piccolo, Enza, Gentile, Roberta, Lamolinara, Alessia, Di Campli, Antonella, Sallese, Michele, Iacobelli, Valentina, Cimini, Annamaria, De Laurenzi, Vincenzo, Lattanzio, Rossano, Piantelli, Mauro, Ippoliti, Rodolfo, Sala, Gianluca, Iacobelli, Stefano

“…Galectin-3-binding protein (Gal-3BP) has been identified as a cancer and metastasis-associated, secreted protein that is expressed by the large majority of…”
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Anti-LGALS3BP antibody-drug conjugate treatment induces durable and potent antitumor response in a preclinical model of adenoid cystic carcinoma by Capone, Emily, Perrotti, Vittoria, Cela, Ilaria, Lattanzio, Rossano, Togni, Lucrezia, Rubini, Corrado, Caponio, Vito Carlo Alberto, Lo Muzio, Lorenzo, Colasante, Martina, Giansanti, Francesco, Ippoliti, Rodolfo, Iacobelli, Stefano, Wick, Michael J, Spardy Burr, Nicole, Sala, Gianluca

“…Adenoid cystic carcinoma (ACC) is a rare type of cancer that typically arises from glandular tissues, most commonly in the salivary glands. Although relatively…”
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BAG3 induces fibroblasts to release key cytokines involved in pancreatic cell migration by Dufrusine, Beatrice, Damiani, Verena, Capone, Emily, Pieragostino, Damiana, Dainese, Enrico, De Marco, Margot, Reppucci, Francesca, Turco, Maria C., Rosati, Alessandra, Marzullo, Liberato, Sala, Gianluca, Sallese, Michele, De Laurenzi, Vincenzo

“…Pancreatic ductal adenoma carcinoma (PDAC) is considered one of the deadliest solid cancers as it is usually diagnosed in advanced stages and has a poor…”
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LGALS3BP is a potential target of antibody‐drug conjugates in oral squamous cell carcinoma by Cela, Ilaria, Caponio, Vito Carlo Alberto, Capone, Emily, Pinti, Morena, Mascitti, Marco, Togni, Lucrezia, Lo Muzio, Lorenzo, Rubini, Corrado, De Laurenzi, Vincenzo, Lattanzio, Rossano, Perrotti, Vittoria, Sala, Gianluca

“…Objective The aim of the present study was to evaluate the expression of intracellular and vesicular LGALS3BP in oral squamous cell carcinoma (OSCC) patients…”
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Visualizing Galectin‑3 Binding Protein Expression with ImmunoPET by Keinänen, Outi, Sarrett, Samantha M., Delaney, Samantha, Rodriguez, Cindy, Dayts, Eric J., Capone, Emily, Sauniere, Frederic, Ippoliti, Rodolfo, Sala, Gianluca, Iacobelli, Stefano, Zeglis, Brian M.

“…Galectin-3 binding protein (Gal-3BP) is a glycoprotein that is overexpressed and secreted by several cancers and has been implicated as a marker of both tumor…”
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Abstract 748: Non-internalizing site-specific antibody-drug conjugates based on maytansinoids display curative properties by Sala, Gianluca, Capone, Emily, Piccolo, Enza, Ponziani, Sara, Gentile, Roberta, Ippoliti, Rodolfo, Giansanti, Francesco, Iacobelli, Stefano

“…Abstract Antibody-Drug Conjugates (ADCs) are highly potent biopharmaceuticals that use the targeting ability of monoclonal antibodies to selectively bind to…”
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Therapeutic Potential of Antibody-Drug Conjugate-Based Therapy in Head and Neck Cancer: A Systematic Review by Perrotti, Vittoria, Caponio, Vito Carlo Alberto, Mascitti, Marco, Lo Muzio, Lorenzo, Piattelli, Adriano, Rubini, Corrado, Capone, Emily, Sala, Gianluca

“…Antibody-drug conjugates (ADCs) are designed to deliver potent cytotoxic agents into tumor tissues. During the last two decades, a plethora of ADCs have been…”
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