Maternal Inherited Thrombophilia in Monochorionic Twin Pregnancy with Twin-Twin Transfusion Syndrome

Maternal Inherited Thrombophilia in Monochorionic Twin Pregnancy with Twin-Twin Transfusion Syndrome

To study the frequency of inherited thrombophilia in monochorionic twin pregnancies with twin-twin transfusion syndrome (TTTS). At the Department of Obstetrics of the Polytechnic University of Marche (Ancona, Italy) a population of monochorionic diamniotic pregnant women was selected retrospectively...

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Bibliographic Details
Published in:Journal of clinical medicine Vol. 11; no. 23; p. 7054
Main Authors: Giannubilo, Stefano R, Fiorelli, Alessia, Marzioni, Daniela, Tossetta, Giovanni, Capogrosso, Giulia, Ciavattini, Andrea
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 29-11-2022
MDPI
Subjects:
Anticoagulants
Clinical medicine
Fetuses
Mutation
Obstetrics
Polymorphism
Pregnancy
Proteins
Thrombosis
Twins
Italy
TTTS
monochorionic
thrombophilia
twins
placenta
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Summary:To study the frequency of inherited thrombophilia in monochorionic twin pregnancies with twin-twin transfusion syndrome (TTTS). At the Department of Obstetrics of the Polytechnic University of Marche (Ancona, Italy) a population of monochorionic diamniotic pregnant women was selected retrospectively. After termination of the pregnancy, genotyping for Factor I, Factor V Leiden, Factor II and Methylenetetrahydrofolate Reductase (MTHFR), as well as activities of the plasma proteins C and S, was performed. Regarding the 32 patients with TTTS, from a cohort of 104 monochorionic pregnancies recruited, at least one thrombophilic defect was more frequent (OR: 3.24), and the allele polymorphism frequency was higher for Factor I (OR: 4.4) and for Factor V Leiden (OR: 11.66). Maternal inherited thrombophilia, possibly also inherited from monochorial fetuses, may result in impaired development of the placental vascular architecture. This inheritance hypothesis may explain why only a fraction of monochorionic diamniotic twins develop TTTS.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11237054