Search Results - "Capocci, Luca"

Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease by Di Pardo, Alba, Amico, Enrico, Scalabrì, Francesco, Pepe, Giuseppe, Castaldo, Salvatore, Elifani, Francesca, Capocci, Luca, De Sanctis, Claudia, Comerci, Laura, Pompeo, Francesco, D’Esposito, Maurizio, Filosa, Stefania, Crispi, Stefania, Maglione, Vittorio

“…Blood-brain barrier (BBB) breakdown, due to the concomitant disruption of the tight junctions (TJs), normally required for the maintenance of BBB function, and…”
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Treatment with the Glycosphingolipid Modulator THI Rescues Myelin Integrity in the Striatum of R6/2 HD Mice by Pepe, Giuseppe, Lenzi, Paola, Capocci, Luca, Marracino, Federico, Pizzati, Ludovica, Scarselli, Pamela, Di Pardo, Alba, Fornai, Francesco, Maglione, Vittorio

“…Huntington's disease is one of the most common dominantly inherited neurodegenerative disorders caused by an expansion of a polyglutamine (polyQ) stretch in…”
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Polysialic Acid Sustains the Hypoxia-Induced Migration and Undifferentiated State of Human Glioblastoma Cells by Rosa, Paolo, Scibetta, Sofia, Pepe, Giuseppe, Mangino, Giorgio, Capocci, Luca, Moons, Sam J., Boltje, Thomas J., Fazi, Francesco, Petrozza, Vincenzo, Di Pardo, Alba, Maglione, Vittorio, Calogero, Antonella

“…Gliomas are the most common primary malignant brain tumors. Glioblastoma, IDH-wildtype (GBM, CNS WHO grade 4) is the most aggressive form of glioma and is…”
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Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity by Ferlazzo, Giorgia Maria, Gambetta, Anna Maria, Amato, Sonia, Cannizzaro, Noemi, Angiolillo, Silvia, Arboit, Mattia, Diamante, Linda, Carbognin, Elena, Romani, Patrizia, La Torre, Federico, Galimberti, Elena, Pflug, Florian, Luoni, Mirko, Giannelli, Serena, Pepe, Giuseppe, Capocci, Luca, Di Pardo, Alba, Vanzani, Paola, Zennaro, Lucio, Broccoli, Vania, Leeb, Martin, Moro, Enrico, Maglione, Vittorio, Martello, Graziano

“…Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG-repeat expansions in the huntingtin ( HTT ) gene. The resulting mutant HTT (mHTT)…”
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Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage by Pepe, Giuseppe, Cotugno, Maria, Marracino, Federico, Giova, Susy, Capocci, Luca, Forte, Maurizio, Stanzione, Rosita, Bianchi, Franca, Marchitti, Simona, Di Pardo, Alba, Sciarretta, Sebastiano, Rubattu, Speranza, Maglione, Vittorio

“…Alterations in the metabolism of sphingolipids, a class of biologically active molecules in cell membranes with direct effect on vascular homeostasis, are…”
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Morus alba extract modulates blood pressure homeostasis through eNOS signaling by Carrizzo, Albino, Ambrosio, Mariateresa, Damato, Antonio, Madonna, Michele, Storto, Marianna, Capocci, Luca, Campiglia, Pietro, Sommella, Eduardo, Trimarco, Valentina, Rozza, Francesco, Izzo, Raffaele, Puca, Annibale A., Vecchione, Carmine

“…Scope Morus alba is a promising phytomedicine cultivated in oriental countries that is extensively used to prevent and treat various cardiovascular problems…”
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Blood-Brain Barrier Integrity Is Perturbed in a Mecp2 -Null Mouse Model of Rett Syndrome by Pepe, Giuseppe, Fioriniello, Salvatore, Marracino, Federico, Capocci, Luca, Maglione, Vittorio, D'Esposito, Maurizio, Di Pardo, Alba, Della Ragione, Floriana

“…Rett syndrome (RTT, online MIM 312750) is a devastating neurodevelopmental disorder characterized by motor and cognitive disabilities. It is mainly caused by…”
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Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model by Di Pardo, Alba, Pepe, Giuseppe, Castaldo, Salvatore, Marracino, Federico, Capocci, Luca, Amico, Enrico, Madonna, Michele, Giova, Susy, Jeong, Se Kyoo, Park, Bu-Mahn, Park, Byeong Deog, Maglione, Vittorio

“…Although several agents have been identified to provide therapeutic benefits in Huntington disease (HD), the number of conventionally used treatments remains…”
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Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension? by Fazio, Francesco, Carrizzo, Albino, Lionetto, Luana, Damato, Antonio, Capocci, Luca, Ambrosio, Mariateresa, Battaglia, Giuseppe, Bruno, Valeria, Madonna, Michele, Simmaco, Maurizio, Nicoletti, Ferdinando, Vecchione, Carmine

“…The of tryptophan metabolism is activated by pro-inflammatory cytokines. L-kynurenine, an upstream metabolite of the pathway, acts as a putative…”
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Brain Region and Cell Compartment Dependent Regulation of Electron Transport System Components in Huntington’s Disease Model Mice by Burtscher, Johannes, Pepe, Giuseppe, Marracino, Federico, Capocci, Luca, Giova, Susy, Millet, Grégoire P., Di Pardo, Alba, Maglione, Vittorio

“…Huntington’s disease (HD) is a rare hereditary neurodegenerative disorder characterized by multiple metabolic dysfunctions including defects in mitochondrial…”
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Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction by Carrizzo, Albino, Vecchione, Carmine, Damato, Antonio, Nonno, Flavio, Ambrosio, Mariateresa, Pompeo, Franco, Cappello, Enrico, Capocci, Luca, Peruzzi, Mariangela, Valenti, Valentina, Biondi‐Zoccai, Giuseppe, Marullo, Antonino G. M., Palmerio, Silvia, Carnevale, Roberto, Spinelli, Chiara C., Puca, Annibale A., Rubattu, Speranza, Volpe, Massimo, Sadoshima, Junichi, Frati, Giacomo, Sciarretta, Sebastiano

“…Background Endothelial dysfunction contributes significantly to the development of vascular diseases. However, a therapy able to reduce this derangement still…”
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I08 Passive immunization, with the anti-huntingtin aggregate antibody EM48, is beneficial in R6/2 mouse model by Pepe, Giuseppe, Capocci, Luca, Marracino, Federico, Cicco, Clotilde Di, Scarselli, Pamela, Parlato, Rosanna, Pardo, Alba Di, Maglione, Vittorio

“…BackgroundA critical step in the molecular events leading to mutant huntingtin (mHtt) toxicity, in Huntington’s disease (HD), is the generation of N-terminal…”
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I18 Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase (SGPL1), modulates glycosphingolipid metabolism and results therapeutically effective in a mouse model of Huntington’s disease by Pepe, Giuseppe, Capocci, Luca, Marracino, Federico, Realini, Natalia, Scarselli, Pamela, Cicco, Clotilde Di, Armirotti, Andrea, Parlato, Rosanna, Pardo, Alba Di, Maglione, Vittorio

“…BackgroundOver the past few years our research has shown that alterations in sphingolipid metabolism represent a critical determinant in Huntington’s disease…”
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Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models by Pepe, Giuseppe, Cotugno, Maria, Marracino, Federico, Capocci, Luca, Pizzati, Ludovica, Forte, Maurizio, Stanzione, Rosita, Scarselli, Pamela, Di Pardo, Alba, Sciarretta, Sebastiano, Volpe, Massimo, Rubattu, Speranza, Maglione, Vittorio

“…Sphingolipids exert important roles within the cardiovascular system and related diseases. Perturbed sphingolipid metabolism was previously reported in…”
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I19 The defective metabolism of polysialic acid (polysia) may represent an effective therapeutic target in hd pre-clinical models by Pepe, Giuseppe, Capocci, Luca, Marracino, Federico, Moons, Sam J, Sönmez, Aynur, Świtońska-Kurkowska, Karolina, Scarselli, Pamela, Cicco, Clotilde Di, Figiel, Maciej, Boltje, Thomas J, Parlato, Rosanna, Pardo, Alba Di, Maglione, Vittorio

“…BackgroundEvidence indicates that defective metabolism of sialic acid-containing glycosphingolipids (gangliosides) play role in the pathogenesis of…”
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I16 Stimulation of SPHK1 with selective activator K6PC-5 is beneficial in the transgenic R6/2 mouse model of huntington disease by Alba Di Pardo, Castaldo, Salvatore, Capocci, Luca, Giovannelli, Alfredo, Amico, Enrico, Jeong, Se Kyoo, Maglione, Vittorio

“…BackgroundHuntington’s disease (HD) is the most common neurodegenerative disorder with no effective cure currently available. Although several agents have been…”
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I15 Inhibition of S1P degradation is beneficial in the transgenic R6/2 mouse model of huntington disease by Alba Di Pardo, Castaldo, Salvatore, Amico, Enrico, Capocci, Luca, Pepe, Giuseppe, Maglione, Vittorio

“…BackgroundHuntington’s disease (HD) is the most common neurodegenerative disorder with no effective cure currently available. Over the past few years our…”
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Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington’s disease by Pepe, Giuseppe, Capocci, Luca, Marracino, Federico, Realini, Natalia, Lenzi, Paola, Martinello, Katiuscia, Bovier, Tiziana Francesca, Bichell, Terry Jo, Scarselli, Pamela, Di Cicco, Clotilde, Bowman, Aaron B., Digilio, Filomena A., Fucile, Sergio, Fornai, Francesco, Armirotti, Andrea, Parlato, Rosanna, Di Pardo, Alba, Maglione, Vittorio

“…Huntington’s disease (HD) is a fatal neurodegenerative disorder with no effective cure currently available. Over the past few years our research has shown that…”
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I10 A genome-wide screening in pluripotent cells identifies MTF1 as a novel suppressor of mutant huntingtin toxicity by Ferlazzo, Giorgia Maria, Gambetta, Anna Maria, Amato, Sonia, Cannizzaro, Noemi, Angiolillo, Silvia, Arboit, Mattia, Galimberti, Elena, Pflug, Florian, Carbognin, Elena, Luoni, Mirko, Giannelli, Serena, Pepe, Giuseppe, Capocci, Luca, Pardo, Alba Di, Broccoli, Vania, Leeb, Martin, Moro, Enrico, Maglione, Vittorio, Martello, Graziano

“…BackgroundHuntington’s disease (HD) is an inherited and incurable neurodegenerative disorder caused by CAG repeat expansions in the huntingtin (HTT) gene. The…”
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Blood–Brain Barrier Integrity Is Perturbed in a IMecp2/I-Null Mouse Model of Rett Syndrome by Pepe, Giuseppe, Fioriniello, Salvatore, Marracino, Federico, Capocci, Luca, Maglione, Vittorio, D’Esposito, Maurizio, Di Pardo, Alba, Della Ragione, Floriana

“…Rett syndrome (RTT, online MIM 312750) is a devastating neurodevelopmental disorder characterized by motor and cognitive disabilities. It is mainly caused by…”
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